O10J5_HUMAN
ID O10J5_HUMAN Reviewed; 309 AA.
AC Q8NHC4; B9EH35; Q6IFH2;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Olfactory receptor 10J5 {ECO:0000312|HGNC:HGNC:14993};
DE AltName: Full=Olfactory receptor OR1-28;
GN Name=OR10J5 {ECO:0000312|HGNC:HGNC:14993};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN [7]
RP TISSUE SPECIFICITY, AND FUNCTION.
RX PubMed=25791473; DOI=10.1016/j.bbrc.2015.03.046;
RA Kim S.H., Yoon Y.C., Lee A.S., Kang N., Koo J., Rhyu M.R., Park J.H.;
RT "Expression of human olfactory receptor 10J5 in heart aorta, coronary
RT artery, and endothelial cells and its functional role in angiogenesis.";
RL Biochem. Biophys. Res. Commun. 460:404-408(2015).
RN [8]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=28842679; DOI=10.1038/s41598-017-10379-x;
RA Tong T., Ryu S.E., Min Y., de March C.A., Bushdid C., Golebiowski J.,
RA Moon C., Park T.;
RT "Olfactory receptor 10J5 responding to alpha-cedrene regulates hepatic
RT steatosis via the cAMP-PKA pathway.";
RL Sci. Rep. 7:9471-9471(2017).
CC -!- FUNCTION: Olfactory receptor. Activated by the synthetic floral
CC odorant, lyral, and by alpha-cedrene, a sesquiterpene constituent of
CC cedarwood oil. Its activation increases intracellular Ca(2+)
CC (PubMed:25791473, PubMed:28842679). Acts as a key regulator of
CC myogenesis through its actions on cell migration and adhesion by
CC activating the Ca(2+)-dependent AKT signal transduction pathway (By
CC similarity). Acts also as a regulator of angiogenesis
CC (PubMed:25791473). Moreover, plays a role in the regulation of lipid
CC accumulation in hepatocytes via the cAMP-PKA pathway (PubMed:28842679).
CC May be involved in sperm chemotaxis and motility (By similarity).
CC {ECO:0000250|UniProtKB:Q62007, ECO:0000269|PubMed:25791473,
CC ECO:0000269|PubMed:28842679}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28842679};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in both the aorta, the coronary artery
CC and umbilical vein endothelial cells (HUVECs) (at protein level).
CC {ECO:0000269|PubMed:25791473}.
CC -!- MISCELLANEOUS: The mouse olfactory receptor Olfr16 is the ortholog of
CC human OR10J5. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10J5";
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DR EMBL; AB065443; BAC05709.1; -; Genomic_DNA.
DR EMBL; AL606752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471121; EAW52783.1; -; Genomic_DNA.
DR EMBL; BC137025; AAI37026.1; -; mRNA.
DR EMBL; BC137026; AAI37027.1; -; mRNA.
DR EMBL; BK004290; DAA04688.1; -; Genomic_DNA.
DR CCDS; CCDS30910.1; -.
DR RefSeq; NP_001004469.1; NM_001004469.1.
DR AlphaFoldDB; Q8NHC4; -.
DR SMR; Q8NHC4; -.
DR BioGRID; 126054; 3.
DR STRING; 9606.ENSP00000334441; -.
DR GlyGen; Q8NHC4; 1 site.
DR BioMuta; OR10J5; -.
DR DMDM; 38372836; -.
DR PaxDb; Q8NHC4; -.
DR PeptideAtlas; Q8NHC4; -.
DR PRIDE; Q8NHC4; -.
DR Antibodypedia; 20471; 135 antibodies from 24 providers.
DR DNASU; 127385; -.
DR Ensembl; ENST00000334857.3; ENSP00000334441.2; ENSG00000184155.8.
DR GeneID; 127385; -.
DR KEGG; hsa:127385; -.
DR MANE-Select; ENST00000334857.3; ENSP00000334441.2; NM_001004469.1; NP_001004469.1.
DR UCSC; uc010piw.2; human.
DR CTD; 127385; -.
DR DisGeNET; 127385; -.
DR GeneCards; OR10J5; -.
DR HGNC; HGNC:14993; OR10J5.
DR HPA; ENSG00000184155; Not detected.
DR MIM; 619546; gene.
DR neXtProt; NX_Q8NHC4; -.
DR OpenTargets; ENSG00000184155; -.
DR PharmGKB; PA31986; -.
DR VEuPathDB; HostDB:ENSG00000184155; -.
DR eggNOG; ENOG502RU27; Eukaryota.
DR GeneTree; ENSGT00940000159272; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8NHC4; -.
DR OMA; ILATNNC; -.
DR OrthoDB; 1043779at2759; -.
DR PhylomeDB; Q8NHC4; -.
DR TreeFam; TF337624; -.
DR PathwayCommons; Q8NHC4; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 127385; 10 hits in 664 CRISPR screens.
DR GeneWiki; OR10J5; -.
DR GenomeRNAi; 127385; -.
DR Pharos; Q8NHC4; Tdark.
DR PRO; PR:Q8NHC4; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NHC4; protein.
DR Bgee; ENSG00000184155; Expressed in liver.
DR ExpressionAtlas; Q8NHC4; baseline and differential.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IDA:UniProtKB.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; ISS:UniProtKB.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IDA:UniProtKB.
DR GO; GO:0055088; P:lipid homeostasis; IMP:UniProtKB.
DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR GO; GO:0045765; P:regulation of angiogenesis; IMP:UniProtKB.
DR GO; GO:0051147; P:regulation of muscle cell differentiation; ISS:UniProtKB.
DR GO; GO:0007608; P:sensory perception of smell; IDA:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Angiogenesis; Cell membrane; Disulfide bond; G-protein coupled receptor;
KW Glycoprotein; Membrane; Myogenesis; Olfaction; Receptor;
KW Reference proteome; Sensory transduction; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 10J5"
FT /id="PRO_0000150709"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 233
FT /note="R -> W (in dbSNP:rs35393723)"
FT /id="VAR_062064"
SQ SEQUENCE 309 AA; 34401 MW; EB1770EBC32074EB CRC64;
MKRKNFTEVS EFIFLGFSSF GKHQITLFVV FLTVYILTLV ANIIIVTIIC IDHHLHTPMY
FFLSMLASSE TVYTLVIVPR MLLSLIFHNQ PISLAGCATQ MFFFVILATN NCFLLTAMGY
DRYVAICRPL RYTVIMSKGL CAQLVCGSFG IGLTMAVLHV TAMFNLPFCG TVVDHFFCDI
YPVMKLSCID TTINEIINYG VSSFVIFVPI GLIFISYVLV ISSILQIASA EGRKKTFATC
VSHLTVVIVH CGCASIAYLK PKSESSIEKD LVLSVTYTII TPLLNPVVYS LRNKEVKDAL
CRVVGRNIS
