O10Q1_HUMAN
ID O10Q1_HUMAN Reviewed; 319 AA.
AC Q8NGQ4; B9EIL7; Q6IFG4;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Olfactory receptor 10Q1;
DE AltName: Full=Olfactory receptor OR11-233;
GN Name=OR10Q1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ASP-12 AND CYS-191.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10Q1";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065735; BAC05956.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW73801.1; -; Genomic_DNA.
DR EMBL; BC140731; AAI40732.1; -; mRNA.
DR EMBL; BK004298; DAA04696.1; -; Genomic_DNA.
DR CCDS; CCDS31547.1; -.
DR RefSeq; NP_001004471.1; NM_001004471.2.
DR AlphaFoldDB; Q8NGQ4; -.
DR SMR; Q8NGQ4; -.
DR STRING; 9606.ENSP00000314324; -.
DR GlyGen; Q8NGQ4; 1 site.
DR iPTMnet; Q8NGQ4; -.
DR PhosphoSitePlus; Q8NGQ4; -.
DR BioMuta; OR10Q1; -.
DR DMDM; 38372748; -.
DR MassIVE; Q8NGQ4; -.
DR PaxDb; Q8NGQ4; -.
DR PeptideAtlas; Q8NGQ4; -.
DR PRIDE; Q8NGQ4; -.
DR Antibodypedia; 62821; 17 antibodies from 12 providers.
DR DNASU; 219960; -.
DR Ensembl; ENST00000316770.2; ENSP00000314324.2; ENSG00000180475.4.
DR GeneID; 219960; -.
DR KEGG; hsa:219960; -.
DR MANE-Select; ENST00000316770.2; ENSP00000314324.2; NM_001004471.2; NP_001004471.1.
DR UCSC; uc010rkd.2; human.
DR CTD; 219960; -.
DR GeneCards; OR10Q1; -.
DR HGNC; HGNC:15134; OR10Q1.
DR HPA; ENSG00000180475; Not detected.
DR neXtProt; NX_Q8NGQ4; -.
DR PharmGKB; PA31994; -.
DR VEuPathDB; HostDB:ENSG00000180475; -.
DR eggNOG; ENOG502RKK8; Eukaryota.
DR GeneTree; ENSGT01040000240424; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8NGQ4; -.
DR OMA; LCTQMLG; -.
DR OrthoDB; 1066478at2759; -.
DR PhylomeDB; Q8NGQ4; -.
DR TreeFam; TF352734; -.
DR PathwayCommons; Q8NGQ4; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219960; 11 hits in 671 CRISPR screens.
DR GeneWiki; OR10Q1; -.
DR GenomeRNAi; 219960; -.
DR Pharos; Q8NGQ4; Tdark.
DR PRO; PR:Q8NGQ4; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGQ4; protein.
DR Bgee; ENSG00000180475; Expressed in stromal cell of endometrium and 16 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..319
FT /note="Olfactory receptor 10Q1"
FT /id="PRO_0000150714"
FT TOPO_DOM 1..29
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..222
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..242
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..319
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 9
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 101..194
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 12
FT /note="E -> D (in dbSNP:rs4245219)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_024129"
FT VARIANT 191
FT /note="R -> C (in dbSNP:rs11229301)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_062065"
SQ SEQUENCE 319 AA; 35602 MW; FC7D971B8D29834E CRC64;
MPVGKLVFNQ SEPTEFVFRA FTTATEFQVL LFLLFLLLYL MILCGNTAII WVVCTHSTLR
TPMYFFLSNL SFLELCYTTV VVPLMLSNIL GAQKPISLAG CGAQMFFFVT LGSTDCFLLA
IMAYDRYVAI CHPLHYTLIM TRELCTQMLG GALGLALFPS LQLTALIFTL PFCGHHQEIN
HFLCDVPPVL RLACADIRVH QAVLYVVSIL VLTIPFLLIC VSYVFITCAI LSIRSAEGRR
RAFSTCSFHL TVVLLQYGCC SLVYLRPRSS TSEDEDSQIA LVYTFVTPLL NPLLYSLRNK
DVKGALRSAI IRKAASDAN
