O10S1_HUMAN
ID O10S1_HUMAN Reviewed; 331 AA.
AC Q8NGN2; B9EH43; Q6IEV3; Q96R78;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 10S1;
DE AltName: Full=Olfactory receptor OR11-279;
GN Name=OR10S1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-295.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-10 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05978.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10S1";
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DR EMBL; AB065758; BAC05978.1; ALT_INIT; Genomic_DNA.
DR EMBL; AP001884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137037; AAI37038.1; -; mRNA.
DR EMBL; BC137038; AAI37039.1; -; mRNA.
DR EMBL; AF399565; AAK95050.1; -; Genomic_DNA.
DR EMBL; BK004509; DAA04907.1; -; Genomic_DNA.
DR RefSeq; NP_001004474.1; NM_001004474.1.
DR AlphaFoldDB; Q8NGN2; -.
DR SMR; Q8NGN2; -.
DR BioGRID; 128589; 10.
DR STRING; 9606.ENSP00000431914; -.
DR GlyGen; Q8NGN2; 1 site.
DR iPTMnet; Q8NGN2; -.
DR PhosphoSitePlus; Q8NGN2; -.
DR BioMuta; OR10S1; -.
DR DMDM; 223590111; -.
DR MassIVE; Q8NGN2; -.
DR PaxDb; Q8NGN2; -.
DR PeptideAtlas; Q8NGN2; -.
DR PRIDE; Q8NGN2; -.
DR Antibodypedia; 18962; 117 antibodies from 24 providers.
DR DNASU; 219873; -.
DR GeneID; 219873; -.
DR KEGG; hsa:219873; -.
DR UCSC; uc001pzm.2; human.
DR CTD; 219873; -.
DR GeneCards; OR10S1; -.
DR HGNC; HGNC:14807; OR10S1.
DR HPA; ENSG00000196248; Not detected.
DR neXtProt; NX_Q8NGN2; -.
DR PharmGKB; PA31999; -.
DR VEuPathDB; HostDB:ENSG00000196248; -.
DR eggNOG; ENOG502SI4A; Eukaryota.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGN2; -.
DR OrthoDB; 1154694at2759; -.
DR PhylomeDB; Q8NGN2; -.
DR TreeFam; TF352732; -.
DR PathwayCommons; Q8NGN2; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219873; 5 hits in 670 CRISPR screens.
DR GeneWiki; OR10S1; -.
DR GenomeRNAi; 219873; -.
DR Pharos; Q8NGN2; Tdark.
DR PRO; PR:Q8NGN2; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGN2; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..331
FT /note="Olfactory receptor 10S1"
FT /id="PRO_0000150716"
FT TOPO_DOM 1..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..67
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..113
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..153
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..211
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..231
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 232..251
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..283
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 305..331
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 111..203
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 63
FT /note="G -> S (in dbSNP:rs17759513)"
FT /id="VAR_054358"
FT VARIANT 93
FT /note="K -> R (in dbSNP:rs17686210)"
FT /id="VAR_054359"
FT VARIANT 112
FT /note="A -> V (in dbSNP:rs17759447)"
FT /id="VAR_054360"
SQ SEQUENCE 331 AA; 36501 MW; 50DA45E36CA595D6 CRC64;
MTSRSVCEKM TMTTENPNQT VVSHFFLEGL RYTAKHSSLF FLLFLLIYSI TVAGNLLILL
TVGSDSHLSL PMYHFLGHLS FLDACLSTVT VPKVMAGLLT LDGKVISFEG CAVQLYCFHF
LASTECFLYT VMAYDRYLAI CQPLHYPVAM NRRMCAEMAG ITWAIGATHA AIHTSLTFRL
LYCGPCHIAY FFCDIPPVLK LACTDTTINE LVMLASIGIV AAGCLILIVI SYIFIVAAVL
RIRTAQGRQR AFSPCTAQLT GVLLYYVPPV CIYLQPRSSE AGAGAPAVFY TIVTPMLNPF
IYTLRNKEVK HALQRLLCSS FRESTAGSPP P
