O10T2_HUMAN
ID O10T2_HUMAN Reviewed; 314 AA.
AC Q8NGX3; Q6IF98;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Olfactory receptor 10T2;
DE AltName: Full=Olfactory receptor OR1-3;
GN Name=OR10T2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10T2";
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DR EMBL; AB065643; BAC05869.1; -; Genomic_DNA.
DR EMBL; AL121986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004364; DAA04762.1; -; Genomic_DNA.
DR CCDS; CCDS30895.1; -.
DR RefSeq; NP_001004475.1; NM_001004475.1.
DR AlphaFoldDB; Q8NGX3; -.
DR SMR; Q8NGX3; -.
DR STRING; 9606.ENSP00000334115; -.
DR GlyGen; Q8NGX3; 1 site.
DR iPTMnet; Q8NGX3; -.
DR PhosphoSitePlus; Q8NGX3; -.
DR BioMuta; OR10T2; -.
DR DMDM; 38372780; -.
DR MassIVE; Q8NGX3; -.
DR PaxDb; Q8NGX3; -.
DR PeptideAtlas; Q8NGX3; -.
DR PRIDE; Q8NGX3; -.
DR Antibodypedia; 57095; 86 antibodies from 19 providers.
DR DNASU; 128360; -.
DR Ensembl; ENST00000334438.1; ENSP00000334115.1; ENSG00000186306.1.
DR GeneID; 128360; -.
DR KEGG; hsa:128360; -.
DR MANE-Select; ENST00000334438.1; ENSP00000334115.1; NM_001004475.1; NP_001004475.1.
DR UCSC; uc010pih.2; human.
DR CTD; 128360; -.
DR DisGeNET; 128360; -.
DR GeneCards; OR10T2; -.
DR HGNC; HGNC:14816; OR10T2.
DR HPA; ENSG00000186306; Not detected.
DR neXtProt; NX_Q8NGX3; -.
DR PharmGKB; PA32001; -.
DR VEuPathDB; HostDB:ENSG00000186306; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT00940000164107; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGX3; -.
DR OMA; YFCDMAP; -.
DR OrthoDB; 1004544at2759; -.
DR PhylomeDB; Q8NGX3; -.
DR TreeFam; TF337249; -.
DR PathwayCommons; Q8NGX3; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 128360; 12 hits in 670 CRISPR screens.
DR GeneWiki; OR10T2; -.
DR GenomeRNAi; 128360; -.
DR Pharos; Q8NGX3; Tdark.
DR PRO; PR:Q8NGX3; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NGX3; protein.
DR ExpressionAtlas; Q8NGX3; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 10T2"
FT /id="PRO_0000150717"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 16
FT /note="V -> A (in dbSNP:rs6660222)"
FT /id="VAR_053284"
FT VARIANT 65
FT /note="F -> L (in dbSNP:rs41488350)"
FT /id="VAR_053285"
FT VARIANT 78
FT /note="I -> V (in dbSNP:rs6662597)"
FT /id="VAR_053286"
FT VARIANT 137
FT /note="I -> M (in dbSNP:rs6662382)"
FT /id="VAR_053287"
FT VARIANT 155
FT /note="F -> L (in dbSNP:rs12062580)"
FT /id="VAR_053288"
FT VARIANT 312
FT /note="K -> N (in dbSNP:rs6692949)"
FT /id="VAR_053289"
SQ SEQUENCE 314 AA; 35011 MW; ABD13B73F6CDD152 CRC64;
MRGFNKTTVV TQFILVGFSS LGELQLLLFV IFLLLYLTIL VANVTIMAVI RFSWTLHTPM
YGFLFILSFS ESCYTFVIIP QLLVHLLSDT KTISFMACAT QLFFFLGFAC TNCLLIAVMG
YDRYVAICHP LRYTLIINKR LGLELISLSG ATGFFIALVA TNLICDMRFC GPNRVNHYFC
DMAPVIKLAC TDTHVKELAL FSLSILVIMV PFLLILISYG FIVNTILKIP SAEGKKAFVT
CASHLTVVFV HYGCASIIYL RPKSKSASDK DQLVAVTYTV VTPLLNPLVY SLRNKEVKTA
LKRVLGMPVA TKMS
