O10V1_HUMAN
ID O10V1_HUMAN Reviewed; 309 AA.
AC Q8NGI7; Q6IFD9; Q96R50;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 3.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Olfactory receptor 10V1;
DE AltName: Full=Olfactory receptor OR11-256;
GN Name=OR10V1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ARG-123.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284, AND VARIANT ARG-123.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="https://genome.weizmann.ac.il/horde/card/index/symbol:OR10V1/term:OR10V1/type:keyword";
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DR EMBL; AB065807; BAC06026.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW73852.1; -; Genomic_DNA.
DR EMBL; AF399593; AAK95078.1; -; Genomic_DNA.
DR EMBL; BK004323; DAA04721.1; -; Genomic_DNA.
DR CCDS; CCDS31565.1; -.
DR RefSeq; NP_001005324.1; NM_001005324.1.
DR AlphaFoldDB; Q8NGI7; -.
DR SMR; Q8NGI7; -.
DR STRING; 9606.ENSP00000302199; -.
DR GlyGen; Q8NGI7; 1 site.
DR BioMuta; OR10V1; -.
DR DMDM; 116242686; -.
DR MassIVE; Q8NGI7; -.
DR PaxDb; Q8NGI7; -.
DR PRIDE; Q8NGI7; -.
DR Antibodypedia; 58855; 98 antibodies from 20 providers.
DR DNASU; 390201; -.
DR Ensembl; ENST00000307552.3; ENSP00000302199.2; ENSG00000172289.3.
DR GeneID; 390201; -.
DR KEGG; hsa:390201; -.
DR MANE-Select; ENST00000307552.3; ENSP00000302199.2; NM_001005324.1; NP_001005324.1.
DR UCSC; uc001nof.2; human.
DR CTD; 390201; -.
DR GeneCards; OR10V1; -.
DR HGNC; HGNC:15136; OR10V1.
DR HPA; ENSG00000172289; Not detected.
DR neXtProt; NX_Q8NGI7; -.
DR PharmGKB; PA32003; -.
DR VEuPathDB; HostDB:ENSG00000172289; -.
DR eggNOG; ENOG502SKMP; Eukaryota.
DR GeneTree; ENSGT01040000240424; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8NGI7; -.
DR OMA; WPLCVEL; -.
DR OrthoDB; 984246at2759; -.
DR PhylomeDB; Q8NGI7; -.
DR TreeFam; TF352734; -.
DR PathwayCommons; Q8NGI7; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390201; 14 hits in 673 CRISPR screens.
DR GeneWiki; OR10V1; -.
DR GenomeRNAi; 390201; -.
DR Pharos; Q8NGI7; Tdark.
DR PRO; PR:Q8NGI7; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGI7; protein.
DR Bgee; ENSG00000172289; Expressed in urinary bladder.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 10V1"
FT /id="PRO_0000150718"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 117
FT /note="V -> A (in dbSNP:rs472177)"
FT /id="VAR_048065"
FT VARIANT 123
FT /note="Q -> R (in dbSNP:rs499033)"
FT /evidence="ECO:0000269|PubMed:12213199, ECO:0000269|Ref.2"
FT /id="VAR_034296"
SQ SEQUENCE 309 AA; 34746 MW; BF43CCF7C95284EC CRC64;
MEGINKTAKM QFFFRPFSPD PEVQMLIFVV FLMMYLTSLG GNATIAVIVQ INHSLHTPMY
FFLANLAVLE IFYTSSITPL ALANLLSMGK TPVSITGCGT QMFFFVFLGG ADCVLLVVMA
YDQFIAICHP LRYRLIMSWS LCVELLVGSL VLGFLLSLPL TILIFHLPFC HNDEIYHFYC
DMPAVMRLAC ADTRVHKTAL YIISFIVLSI PLSLISISYV FIVVAILRIR SAEGRQQAYS
TCSSHILVVL LQYGCTSFIY LSPSSSYSPE MGRVVSVAYT FITPILNPLI YSLRNKELKD
ALRKALRKF
