O10W1_HUMAN
ID O10W1_HUMAN Reviewed; 305 AA.
AC Q8NGF6; A2RUD2; A8MTE1; Q6UXQ2;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Olfactory receptor 10W1;
DE AltName: Full=Olfactory receptor OR11-236;
GN Name=OR10W1; Synonyms=OR10W1P; ORFNames=UNQ6469/PRO34070;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-263.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLN-263.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-263.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [7]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10W1";
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DR EMBL; AB065850; BAC06068.1; -; Genomic_DNA.
DR EMBL; AY358251; AAQ88618.1; -; mRNA.
DR EMBL; AP000435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471076; EAW73802.1; -; Genomic_DNA.
DR EMBL; BC132848; AAI32849.1; -; mRNA.
DR EMBL; BC132850; AAI32851.1; -; mRNA.
DR EMBL; BK004490; DAA04888.1; -; Genomic_DNA.
DR CCDS; CCDS7968.1; -.
DR RefSeq; NP_997257.2; NM_207374.3.
DR AlphaFoldDB; Q8NGF6; -.
DR SMR; Q8NGF6; -.
DR STRING; 9606.ENSP00000378516; -.
DR PhosphoSitePlus; Q8NGF6; -.
DR BioMuta; OR10W1; -.
DR DMDM; 51316487; -.
DR PaxDb; Q8NGF6; -.
DR PeptideAtlas; Q8NGF6; -.
DR PRIDE; Q8NGF6; -.
DR ProteomicsDB; 73498; -.
DR Antibodypedia; 67390; 39 antibodies from 11 providers.
DR DNASU; 81341; -.
DR Ensembl; ENST00000395079.2; ENSP00000378516.2; ENSG00000172772.3.
DR GeneID; 81341; -.
DR KEGG; hsa:81341; -.
DR MANE-Select; ENST00000395079.2; ENSP00000378516.2; NM_207374.3; NP_997257.2.
DR UCSC; uc001nmq.1; human.
DR CTD; 81341; -.
DR GeneCards; OR10W1; -.
DR HGNC; HGNC:15139; OR10W1.
DR HPA; ENSG00000172772; Not detected.
DR neXtProt; NX_Q8NGF6; -.
DR OpenTargets; ENSG00000172772; -.
DR PharmGKB; PA32006; -.
DR VEuPathDB; HostDB:ENSG00000172772; -.
DR eggNOG; ENOG502QW3H; Eukaryota.
DR GeneTree; ENSGT01040000240424; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGF6; -.
DR OMA; FLAYPSC; -.
DR OrthoDB; 1034122at2759; -.
DR PhylomeDB; Q8NGF6; -.
DR TreeFam; TF352734; -.
DR PathwayCommons; Q8NGF6; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 81341; 7 hits in 670 CRISPR screens.
DR GeneWiki; OR10W1; -.
DR GenomeRNAi; 81341; -.
DR Pharos; Q8NGF6; Tdark.
DR PRO; PR:Q8NGF6; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGF6; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Olfaction; Receptor;
KW Reference proteome; Sensory transduction; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..305
FT /note="Olfactory receptor 10W1"
FT /id="PRO_0000150719"
FT TOPO_DOM 1..16
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..45
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..90
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..130
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..188
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..208
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..228
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 250..262
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..305
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VARIANT 263
FT /note="R -> Q (in dbSNP:rs10792156)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.4"
FT /id="VAR_057568"
SQ SEQUENCE 305 AA; 33376 MW; 07D612EFA3044A82 CRC64;
MEFVFLAYPS CPELHILSFL GVSLVYGLII TGNILIVVSI HTETCLCTSM YYFLGSLSGI
EICYTAVVVP HILANTLQSE KTITLLGCAT QMAFFIALGS ADCFLLAAMA YDRYVAICHP
LQYPLLMTLT LCVHLVVASV ISGLFLSLQL VAFIFSLPFC QAQGIEHFFC DVPPVMHVVC
AQSHIHEQSV LVAAILAIAV PFFLITTSYT FIVAALLKIH SAAGRHRAFS TCSSHLTVVL
LQYGCCAFMY LCPSSSYNPK QDRFISLVYT LGTPLLNPLI YALRNSEMKG AVGRVLTRNC
LSQNS
