O10X1_HUMAN
ID O10X1_HUMAN Reviewed; 326 AA.
AC Q8NGY0; Q6IFR8;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Olfactory receptor 10X1;
DE AltName: Full=Olfactory receptor OR1-14;
GN Name=OR10X1; Synonyms=OR10X1P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN [5]
RP POLYMORPHISM.
RX PubMed=12730696; DOI=10.1038/ng1160;
RA Menashe I., Man O., Lancet D., Gilad Y.;
RT "Different noses for different people.";
RL Nat. Genet. 34:143-144(2003).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- POLYMORPHISM: A stop codon at position Trp-66 in the gene coding for
CC this protein is responsible for functional diversity thus producing a
CC pseudogene. The stop codon is more frequent in African-Americans than
CC in non-Africans.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05862.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10X1";
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DR EMBL; AB065636; BAC05862.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL160283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004194; DAA04592.1; -; Genomic_DNA.
DR RefSeq; NP_001004477.1; NM_001004477.1.
DR AlphaFoldDB; Q8NGY0; -.
DR SMR; Q8NGY0; -.
DR IntAct; Q8NGY0; 1.
DR STRING; 9606.ENSP00000357132; -.
DR GlyGen; Q8NGY0; 2 sites.
DR iPTMnet; Q8NGY0; -.
DR PhosphoSitePlus; Q8NGY0; -.
DR BioMuta; OR10X1; -.
DR DMDM; 166214962; -.
DR MassIVE; Q8NGY0; -.
DR PaxDb; Q8NGY0; -.
DR PeptideAtlas; Q8NGY0; -.
DR PRIDE; Q8NGY0; -.
DR ProteomicsDB; 73621; -.
DR Antibodypedia; 78715; 113 antibodies from 23 providers.
DR DNASU; 128367; -.
DR Ensembl; ENST00000623167.1; ENSP00000485609.1; ENSG00000279111.2.
DR GeneID; 128367; -.
DR KEGG; hsa:128367; -.
DR MANE-Select; ENST00000623167.1; ENSP00000485609.1; NM_001004477.1; NP_001004477.1.
DR UCSC; uc010pin.2; human.
DR CTD; 128367; -.
DR DisGeNET; 128367; -.
DR GeneCards; OR10X1; -.
DR HGNC; HGNC:14995; OR10X1.
DR HPA; ENSG00000279111; Not detected.
DR neXtProt; NX_Q8NGY0; -.
DR PharmGKB; PA32007; -.
DR VEuPathDB; HostDB:ENSG00000279111; -.
DR eggNOG; ENOG502SHK4; Eukaryota.
DR GeneTree; ENSGT00940000161831; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGY0; -.
DR OMA; QTMKINQ; -.
DR OrthoDB; 1029633at2759; -.
DR PhylomeDB; Q8NGY0; -.
DR TreeFam; TF337925; -.
DR PathwayCommons; Q8NGY0; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 128367; 10 hits in 666 CRISPR screens.
DR GeneWiki; OR10X1; -.
DR GenomeRNAi; 128367; -.
DR Pharos; Q8NGY0; Tdark.
DR PRO; PR:Q8NGY0; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NGY0; protein.
DR ExpressionAtlas; Q8NGY0; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..326
FT /note="Olfactory receptor 10X1"
FT /id="PRO_0000150720"
FT TOPO_DOM 1..41
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..70
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..115
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..155
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 177..213
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..233
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234..253
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..284
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 306..326
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 209
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 113..205
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 60
FT /note="I -> T (in dbSNP:rs863363)"
FT /id="VAR_053290"
FT VARIANT 81
FT /note="A -> S (in dbSNP:rs950164)"
FT /id="VAR_053291"
FT VARIANT 172
FT /note="S -> P (in dbSNP:rs7550131)"
FT /id="VAR_053292"
FT VARIANT 180
FT /note="F -> L (in dbSNP:rs16840360)"
FT /id="VAR_053293"
SQ SEQUENCE 326 AA; 36446 MW; BFB0BB8E958C15E4 CRC64;
MVLNVYCCFF QISDIQTMKI NQTILKEFIL VGFSVYPHVQ TFLFVVFFCL YLLTLAGNLI
IMGLTWVDRS LHTPMYLFLS ALSFSETCYT LTIVPKMLED LLAKDRSISV TGCSLQMCFF
LGLGGTNCII LTLMGYDRFL AICNPLRYPL LMTNIVCGQL VASACTAGFF ISLTETALIF
RDSFCRPNLV KHFFCHMLAV IRLSCIDSNH TEFIITLISV SGLLGTLLLI ILTDVFIIST
VLRIPSAEGK QKAFTTCASH LTVVIIHFGF ASIVYLKPEA SGDDTLIAVP YTVITPFLSP
IIFSLRNKDM KNAFRRMMGN TVALKK
