O10Z1_HUMAN
ID O10Z1_HUMAN Reviewed; 313 AA.
AC Q8NGY1; Q5VYL0; Q6IFR7;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Olfactory receptor 10Z1;
DE AltName: Full=Olfactory receptor OR1-15;
GN Name=OR10Z1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT THR-294.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10Z1";
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DR EMBL; AB065635; BAC05861.1; -; Genomic_DNA.
DR EMBL; AL353894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471121; EAW52820.1; -; Genomic_DNA.
DR EMBL; BK004195; DAA04593.1; -; Genomic_DNA.
DR CCDS; CCDS30901.1; -.
DR RefSeq; NP_001004478.1; NM_001004478.1.
DR AlphaFoldDB; Q8NGY1; -.
DR SMR; Q8NGY1; -.
DR STRING; 9606.ENSP00000354707; -.
DR GlyGen; Q8NGY1; 1 site.
DR iPTMnet; Q8NGY1; -.
DR PhosphoSitePlus; Q8NGY1; -.
DR BioMuta; OR10Z1; -.
DR DMDM; 38372785; -.
DR MassIVE; Q8NGY1; -.
DR PaxDb; Q8NGY1; -.
DR PeptideAtlas; Q8NGY1; -.
DR PRIDE; Q8NGY1; -.
DR Antibodypedia; 57098; 101 antibodies from 21 providers.
DR DNASU; 128368; -.
DR Ensembl; ENST00000641002.1; ENSP00000493003.1; ENSG00000198967.5.
DR GeneID; 128368; -.
DR KEGG; hsa:128368; -.
DR MANE-Select; ENST00000641002.1; ENSP00000493003.1; NM_001004478.2; NP_001004478.1.
DR UCSC; uc010pio.2; human.
DR CTD; 128368; -.
DR DisGeNET; 128368; -.
DR GeneCards; OR10Z1; -.
DR HGNC; HGNC:14996; OR10Z1.
DR HPA; ENSG00000198967; Tissue enriched (bone).
DR neXtProt; NX_Q8NGY1; -.
DR OpenTargets; ENSG00000198967; -.
DR PharmGKB; PA32009; -.
DR VEuPathDB; HostDB:ENSG00000198967; -.
DR eggNOG; ENOG502T9AF; Eukaryota.
DR GeneTree; ENSGT00940000162983; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGY1; -.
DR OMA; WRGFVFL; -.
DR OrthoDB; 966526at2759; -.
DR PhylomeDB; Q8NGY1; -.
DR TreeFam; TF337249; -.
DR PathwayCommons; Q8NGY1; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 128368; 47 hits in 674 CRISPR screens.
DR GeneWiki; OR10Z1; -.
DR GenomeRNAi; 128368; -.
DR Pharos; Q8NGY1; Tdark.
DR PRO; PR:Q8NGY1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NGY1; protein.
DR Bgee; ENSG00000198967; Expressed in bone marrow and 29 other tissues.
DR ExpressionAtlas; Q8NGY1; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 10Z1"
FT /id="PRO_0000150721"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 294
FT /note="N -> T (in dbSNP:rs857685)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_034297"
SQ SEQUENCE 313 AA; 34609 MW; 5B29E747D07F57FF CRC64;
MGQTNVTSWR DFVFLGFSSS GELQLLLFAL FLSLYLVTLT SNVFIIIAIR LDSHLHTPMY
LFLSFLSFSE TCYTLGIIPR MLSGLAGGDQ AISYVGCAAQ MFFSASWACT NCFLLAAMGF
DRYVAICAPL HYASHMNPTL CAQLVITSFL TGYLFGLGMT LVIFHLSFCS SHEIQHFFCD
TPPVLSLACG DTGPSELRIF ILSLLVLLVS FFFITISYAY ILAAILRIPS AEGQKKAFST
CASHLTVVII HYGCASFVYL RPKASYSLER DQLIAMTYTV VTPLLNPIVY SLRNRAIQTA
LRNAFRGRLL GKG
