O1165_MOUSE
ID O1165_MOUSE Reviewed; 316 AA.
AC Q8VFR8;
DT 03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT 03-AUG-2022, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Olfactory receptor 1165 {ECO:0000305};
GN Name=Olfr1165-ps {ECO:0000312|EMBL:ALI87907.1};
GN Synonyms=Olfr1165 {ECO:0000312|EMBL:AAP71579.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|Proteomes:UP000000589};
RN [1] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:AAP71579.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT of over 400 genes, extensive alternate splicing and unequal expression
RT levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [3] {ECO:0000312|EMBL:ALI87907.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:ALI87907.1};
RA Mainland J.D., Li Y.R., Zhou T., Liu W.L.L., Matsunami H.;
RT "Human Olfactory Receptor Responses to Odorants.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Olfactory receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- POLYMORPHISM: A single nucleotide deletion in the gene coding for this
CC protein is responsible for functional diversity leading to a frameshift
CC and a truncated protein, thus producing a pseudogene. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073448; AAL61111.1; -; Genomic_DNA.
DR EMBL; AY318366; AAP71579.1; -; Genomic_DNA.
DR EMBL; KP290749; ALI87907.1; -; Genomic_DNA.
DR MGI; MGI:3030999; Olfr1165-ps.
DR Proteomes; UP000000589; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..316
FT /note="Olfactory receptor 1165"
FT /id="PRO_0000455979"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 29..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255|RuleBase:RU363047"
FT TOPO_DOM 51..61
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 62..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255|RuleBase:RU363047"
FT TOPO_DOM 81..99
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 100..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255|RuleBase:RU363047"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 142..166
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255|RuleBase:RU363047"
FT TOPO_DOM 167..205
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 206..228
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255|RuleBase:RU363047"
FT TOPO_DOM 229..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 240..263
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255|RuleBase:RU363047"
FT TOPO_DOM 264..268
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 269..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255|RuleBase:RU363047"
FT TOPO_DOM 292..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..181
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 316 AA; 35366 MW; 779CEB3C6E05813A CRC64;
MMLDLGNESS VTMFILSGFS EYPHLHAPLF LLFFMIYTVT LIGNLGIIVV RKVNPKLHTP
MYFFLSHLSF LDICYSSVFT PKLLEILIVE DRTISFKGCM TQFFLICAFV ITEMFMLAVM
AYDRFVAVCN PLLYTVSMSP KLCAFLVAGT YMWGVLCSLT ITYSLLQLSY CGPNIINHFG
CEYSAILSLS CSDPTFSQVV CLTISIFNET CSLLIILASY VFIVVTIIKM PSKGGLQKAF
STCSSHLTAI SIFHGIILLL YCVPNSKNSW LVVKVATVLF TVMIPMLNPL IYSLRNKDVK
GTVSRLMHLK LQAHST
