O1174_RAT
ID O1174_RAT Reviewed; 331 AA.
AC P35896;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Olfactory receptor 1174;
DE AltName: Full=Putative gustatory receptor PTE33;
GN Name=Olr1174;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 59-292.
RC STRAIN=Fischer; TISSUE=Tongue epithelium;
RX PubMed=8380780; DOI=10.1016/0014-5793(93)81302-g;
RA Abe K., Kusakabe Y., Tanemura K., Emori Y., Arai S.;
RT "Multiple genes for G protein-coupled receptors and their expression in
RT lingual epithelia.";
RL FEBS Lett. 316:253-256(1993).
CC -!- FUNCTION: Possible taste receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Tongue specific.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AABR03064473; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; S28998; S28998.
DR RefSeq; NP_001001016.1; NM_001001016.1.
DR AlphaFoldDB; P35896; -.
DR SMR; P35896; -.
DR STRING; 10116.ENSRNOP00000047732; -.
DR GlyGen; P35896; 2 sites.
DR PaxDb; P35896; -.
DR Ensembl; ENSRNOT00000049066; ENSRNOP00000047732; ENSRNOG00000064567.
DR GeneID; 405390; -.
DR KEGG; rno:405390; -.
DR UCSC; RGD:1332742; rat.
DR CTD; 405390; -.
DR RGD; 1332742; Olr1174.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT00940000153686; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; P35896; -.
DR OMA; PSWINDI; -.
DR OrthoDB; 995191at2759; -.
DR PhylomeDB; P35896; -.
DR TreeFam; TF337210; -.
DR PRO; PR:P35896; -.
DR Proteomes; UP000002494; Chromosome 8.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..331
FT /note="Olfactory receptor 1174"
FT /id="PRO_0000069668"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..106
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..331
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 167
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 61
FT /note="F -> L (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 63
FT /note="L -> F (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 72
FT /note="C -> Y (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 76
FT /note="T -> G (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 78
FT /note="V -> I (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 81
FT /note="M -> I (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 88
FT /note="Q -> K (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 115
FT /note="L -> R (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 122
FT /note="C -> R (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 128
FT /note="N -> M (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 134
FT /note="I -> V (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 285
FT /note="L -> F (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 331 AA; 37654 MW; 3E40C7AC8BF7CE32 CRC64;
MKMENHTLIS EFFLLDLSDD PKLQPFLFGL FLSMYLVTML GNLLIILAVS SNSQLHNPMY
FFLSNLSFVD ICFISTTVPK MLVNMQSQTK DISYIECLTQ VYFFNTFVGM DDVLLTLMAY
DCFVAICNPL KYTIIMNPRV CTLLVLMFWI IMFCISLIHV LLMNELNFSR GTKIPHFFCE
LAQVLKVSNS DTHINNIFMY VLSSLLGVIP MTGILMSYSQ IVSSLLRMSS TVSKYKAFST
CGSHLCVVCL FYGSVIGVYF SSSVVLSTQR IMVASLMYTV ISPMLNPFIY SLRNKDVKVA
LGELFIRVAP CPSWINDIIT KFILKNIRQN L
