O11A1_HUMAN
ID O11A1_HUMAN Reviewed; 315 AA.
AC Q9GZK7; A2BF33; A6NFQ3; B0S7T2; Q5ST16; Q9GZK8;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 175.
DE RecName: Full=Olfactory receptor 11A1;
DE AltName: Full=Hs6M1-18;
DE AltName: Full=Olfactory receptor 11A2;
DE AltName: Full=Olfactory receptor OR6-30;
GN Name=OR11A1; Synonyms=OR11A2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT THR-165.
RA Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B.,
RA Volz A., Younger R., Beck S.;
RT "Polymorphic olfactory receptor genes and HLA loci constitute extended
RT haplotypes.";
RL (In) Kasahara M. (eds.);
RL Major histocompatibility complex-evolution, structure, and function,
RL pp.110-130, Springer-Verlag, Tokyo (2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=12637542; DOI=10.1074/jbc.m212424200;
RA Volz A., Ehlers A., Younger R., Forbes S., Trowsdale J., Schnorr D.,
RA Beck S., Ziegler A.;
RT "Complex transcription and splicing of odorant receptor genes.";
RL J. Biol. Chem. 278:19691-19701(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT THR-165.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR11A1";
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DR EMBL; AJ302614; CAC20534.1; -; Genomic_DNA.
DR EMBL; AJ302615; CAC20535.1; -; Genomic_DNA.
DR EMBL; AJ302616; CAC20536.1; -; Genomic_DNA.
DR EMBL; AJ302617; CAC20537.1; -; Genomic_DNA.
DR EMBL; AJ302618; CAC20538.1; -; Genomic_DNA.
DR EMBL; AJ302619; CAC20539.1; -; Genomic_DNA.
DR EMBL; AJ302620; CAC20540.1; -; Genomic_DNA.
DR EMBL; AJ302621; CAC20541.1; -; Genomic_DNA.
DR EMBL; AJ302622; CAC20542.1; -; Genomic_DNA.
DR EMBL; AJ302623; CAC20543.1; -; Genomic_DNA.
DR EMBL; AJ459857; CAD31040.1; -; mRNA.
DR EMBL; AL035542; CAB44508.1; -; Genomic_DNA.
DR EMBL; AL662869; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL645927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX004810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX248400; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX927133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR848056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR388393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03192.1; -; Genomic_DNA.
DR EMBL; BK004208; DAA04606.1; -; Genomic_DNA.
DR CCDS; CCDS34363.1; -.
DR RefSeq; NP_039225.1; NM_013937.3.
DR AlphaFoldDB; Q9GZK7; -.
DR SMR; Q9GZK7; -.
DR STRING; 9606.ENSP00000366354; -.
DR GlyGen; Q9GZK7; 1 site.
DR iPTMnet; Q9GZK7; -.
DR PhosphoSitePlus; Q9GZK7; -.
DR BioMuta; OR11A1; -.
DR DMDM; 14423802; -.
DR PaxDb; Q9GZK7; -.
DR PRIDE; Q9GZK7; -.
DR ProteomicsDB; 80082; -.
DR Antibodypedia; 67971; 77 antibodies from 19 providers.
DR DNASU; 26531; -.
DR Ensembl; ENST00000377148.5; ENSP00000366353.1; ENSG00000204694.13.
DR Ensembl; ENST00000377149.5; ENSP00000366354.1; ENSG00000204694.13.
DR Ensembl; ENST00000383551.7; ENSP00000373043.3; ENSG00000206472.11.
DR Ensembl; ENST00000383645.6; ENSP00000373141.2; ENSG00000206517.12.
DR Ensembl; ENST00000400696.6; ENSP00000383532.2; ENSG00000206472.11.
DR Ensembl; ENST00000400715.5; ENSP00000383550.1; ENSG00000206517.12.
DR Ensembl; ENST00000411967.5; ENSP00000409994.1; ENSG00000223898.8.
DR Ensembl; ENST00000418485.5; ENSP00000400657.1; ENSG00000234347.8.
DR Ensembl; ENST00000418560.5; ENSP00000404787.1; ENSG00000223898.8.
DR Ensembl; ENST00000419773.5; ENSP00000399062.1; ENSG00000234347.8.
DR Ensembl; ENST00000421634.5; ENSP00000400331.1; ENSG00000237258.8.
DR Ensembl; ENST00000427264.5; ENSP00000403427.1; ENSG00000230780.8.
DR Ensembl; ENST00000428144.5; ENSP00000399592.1; ENSG00000237258.8.
DR Ensembl; ENST00000435232.5; ENSP00000398659.1; ENSG00000232289.8.
DR Ensembl; ENST00000440485.5; ENSP00000392324.1; ENSG00000232289.8.
DR Ensembl; ENST00000444884.5; ENSP00000412097.1; ENSG00000230780.8.
DR Ensembl; ENST00000546665.1; ENSP00000447956.1; ENSG00000206472.11.
DR Ensembl; ENST00000547506.1; ENSP00000447215.1; ENSG00000206517.12.
DR Ensembl; ENST00000547645.1; ENSP00000450263.1; ENSG00000230780.8.
DR Ensembl; ENST00000548813.1; ENSP00000447267.1; ENSG00000223898.8.
DR Ensembl; ENST00000549749.1; ENSP00000447745.1; ENSG00000232289.8.
DR Ensembl; ENST00000551986.1; ENSP00000447627.1; ENSG00000234347.8.
DR Ensembl; ENST00000552225.1; ENSP00000447222.1; ENSG00000237258.8.
DR Ensembl; ENST00000641152.2; ENSP00000493093.1; ENSG00000204694.13.
DR GeneID; 26531; -.
DR KEGG; hsa:26531; -.
DR MANE-Select; ENST00000377149.5; ENSP00000366354.1; NM_001394828.1; NP_001381757.1.
DR UCSC; uc003nmg.3; human.
DR CTD; 26531; -.
DR GeneCards; OR11A1; -.
DR HGNC; HGNC:8176; OR11A1.
DR HPA; ENSG00000204694; Not detected.
DR neXtProt; NX_Q9GZK7; -.
DR OpenTargets; ENSG00000204694; -.
DR PharmGKB; PA32010; -.
DR VEuPathDB; HostDB:ENSG00000204694; -.
DR eggNOG; ENOG502SKM8; Eukaryota.
DR GeneTree; ENSGT00940000163392; -.
DR HOGENOM; CLU_012526_0_1_1; -.
DR InParanoid; Q9GZK7; -.
DR OMA; TWLSGFM; -.
DR OrthoDB; 903559at2759; -.
DR PhylomeDB; Q9GZK7; -.
DR TreeFam; TF337187; -.
DR PathwayCommons; Q9GZK7; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 26531; 6 hits in 664 CRISPR screens.
DR GeneWiki; OR11A1; -.
DR GenomeRNAi; 26531; -.
DR Pharos; Q9GZK7; Tdark.
DR PRO; PR:Q9GZK7; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9GZK7; protein.
DR Bgee; ENSG00000204694; Expressed in testis and 2 other tissues.
DR ExpressionAtlas; Q9GZK7; baseline and differential.
DR Genevisible; Q9GZK7; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..315
FT /note="Olfactory receptor 11A1"
FT /id="PRO_0000150722"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..315
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 121
FT /note="Y -> C (in dbSNP:rs16894898)"
FT /id="VAR_053294"
FT VARIANT 165
FT /note="A -> T (in allele 6M1-18*02; dbSNP:rs9257857)"
FT /evidence="ECO:0000269|PubMed:14574404, ECO:0000269|Ref.1"
FT /id="VAR_010955"
SQ SEQUENCE 315 AA; 35250 MW; 0448A2166A301387 CRC64;
MEIVSTGNET ITEFVLLGFY DIPELHFLFF IVFTAVYVFI IIGNMLIIVA VVSSQRLHKP
MYIFLANLSF LDILYTSAVM PKMLEGFLQE ATISVAGCLL QFFIFGSLAT AECLLLAVMA
YDRYLAICYP LHYPLLMGPR RYMGLVVTTW LSGFVVDGLV VALVAQLRFC GPNHIDQFYC
DFMLFVGLAC SDPRVAQVTT LILSVFCLTI PFGLILTSYA RIVVAVLRVP AGASRRRAFS
TCSSHLAVVT TFYGTLMIFY VAPSAVHSQL LSKVFSLLYT VVTPLFNPVI YTMRNKEVHQ
ALRKILCIKQ TETLD
