O11G2_HUMAN
ID O11G2_HUMAN Reviewed; 345 AA.
AC Q8NGC1; Q6IF09; Q96R33;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Olfactory receptor 11G2;
DE AltName: Full=Olfactory receptor OR14-34;
GN Name=OR11G2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 106-322.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-35 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC06113.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR11G2";
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DR EMBL; AB065897; BAC06113.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL356019; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF399610; AAK95095.1; -; Genomic_DNA.
DR EMBL; BK004453; DAA04851.1; -; Genomic_DNA.
DR RefSeq; NP_001005503.1; NM_001005503.1.
DR AlphaFoldDB; Q8NGC1; -.
DR SMR; Q8NGC1; -.
DR BioGRID; 133566; 10.
DR STRING; 9606.ENSP00000349930; -.
DR GlyGen; Q8NGC1; 1 site.
DR iPTMnet; Q8NGC1; -.
DR PhosphoSitePlus; Q8NGC1; -.
DR BioMuta; OR11G2; -.
DR DMDM; 212276448; -.
DR PaxDb; Q8NGC1; -.
DR PeptideAtlas; Q8NGC1; -.
DR PRIDE; Q8NGC1; -.
DR ProteomicsDB; 73471; -.
DR Antibodypedia; 57320; 45 antibodies from 15 providers.
DR DNASU; 390439; -.
DR GeneID; 390439; -.
DR KEGG; hsa:390439; -.
DR UCSC; uc010tlb.3; human.
DR CTD; 390439; -.
DR GeneCards; OR11G2; -.
DR HGNC; HGNC:15346; OR11G2.
DR HPA; ENSG00000196832; Not detected.
DR neXtProt; NX_Q8NGC1; -.
DR PharmGKB; PA32012; -.
DR VEuPathDB; HostDB:ENSG00000196832; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGC1; -.
DR OrthoDB; 963464at2759; -.
DR PhylomeDB; Q8NGC1; -.
DR TreeFam; TF337213; -.
DR PathwayCommons; Q8NGC1; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390439; 10 hits in 635 CRISPR screens.
DR ChiTaRS; OR11G2; human.
DR GeneWiki; OR11G2; -.
DR GenomeRNAi; 390439; -.
DR Pharos; Q8NGC1; Tdark.
DR PRO; PR:Q8NGC1; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NGC1; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 2.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..345
FT /note="Olfactory receptor 11G2"
FT /id="PRO_0000150723"
FT TOPO_DOM 1..62
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 84..92
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..135
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..181
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..241
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..264
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..275
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..309
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 331..345
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 43
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 135..217
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 99
FT /note="I -> N (in dbSNP:rs4981822)"
FT /id="VAR_047237"
FT VARIANT 116
FT /note="V -> I (in dbSNP:rs4981088)"
FT /id="VAR_047238"
SQ SEQUENCE 345 AA; 38871 MW; F450CBA808A027A5 CRC64;
MHFLSQNDLN INLIPHLCLH RHSVIAGAFT IHRHMKIFNS PSNSSTFTGF ILLGFPCPRE
GQILLFVLFT VVYLLTLMGN GSIICAVHWD QRLHAPMYIL LANFSFLEIC YVTSTVPSML
ANFLSDTKII SFSGCFLQFY FFFSLGSTEC FFLAVMAFDR YLAICRPLRY PTIMTRRLCT
NLVVNCWVLG FIWFLIPIVN ISQMSFCGSR IIDHFLCDPA PLLTLTCKKG PVIELVFSVL
SPLPVFMLFL FIVGSYALVV RAVLRVPSAA GRRKAFSTCG SHLAVVSLFY GSVLVMYGSP
PSKNEAGKQK TVTLFYSVVT PLLNPVIYSL RNKDMRKALK KFWGT
