O11H4_HUMAN
ID O11H4_HUMAN Reviewed; 324 AA.
AC Q8NGC9; B2RNQ4; Q6IF07;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 11H4;
DE AltName: Full=Olfactory receptor OR14-36;
GN Name=OR11H4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR11H4";
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DR EMBL; AB065887; BAC06104.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66484.1; -; Genomic_DNA.
DR EMBL; BC137054; AAI37055.1; -; mRNA.
DR EMBL; BC137055; AAI37056.1; -; mRNA.
DR EMBL; BK004455; DAA04853.1; -; Genomic_DNA.
DR RefSeq; NP_001004479.1; NM_001004479.1.
DR AlphaFoldDB; Q8NGC9; -.
DR SMR; Q8NGC9; -.
DR STRING; 9606.ENSP00000318997; -.
DR GlyGen; Q8NGC9; 1 site.
DR iPTMnet; Q8NGC9; -.
DR PhosphoSitePlus; Q8NGC9; -.
DR BioMuta; OR11H4; -.
DR DMDM; 38372669; -.
DR EPD; Q8NGC9; -.
DR PaxDb; Q8NGC9; -.
DR PeptideAtlas; Q8NGC9; -.
DR PRIDE; Q8NGC9; -.
DR Antibodypedia; 22003; 27 antibodies from 14 providers.
DR DNASU; 390442; -.
DR GeneID; 390442; -.
DR KEGG; hsa:390442; -.
DR UCSC; uc010tld.3; human.
DR CTD; 390442; -.
DR GeneCards; OR11H4; -.
DR HGNC; HGNC:15347; OR11H4.
DR HPA; ENSG00000176198; Not detected.
DR neXtProt; NX_Q8NGC9; -.
DR PharmGKB; PA32016; -.
DR VEuPathDB; HostDB:ENSG00000176198; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGC9; -.
DR OMA; GFPGCWE; -.
DR OrthoDB; 974722at2759; -.
DR PhylomeDB; Q8NGC9; -.
DR TreeFam; TF338968; -.
DR PathwayCommons; Q8NGC9; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390442; 27 hits in 677 CRISPR screens.
DR GeneWiki; OR11H4; -.
DR GenomeRNAi; 390442; -.
DR Pharos; Q8NGC9; Tdark.
DR PRO; PR:Q8NGC9; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NGC9; protein.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..324
FT /note="Olfactory receptor 11H4"
FT /id="PRO_0000150725"
FT TOPO_DOM 1..35
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..64
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 86..109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..207
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..227
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 228..247
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 269..281
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 303..324
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 12
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 107..199
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 301
FT /note="T -> S (in dbSNP:rs17277270)"
FT /id="VAR_034298"
SQ SEQUENCE 324 AA; 36886 MW; D556E455336C7DC8 CRC64;
MSFFFVDLRP MNRSATHIVT EFILLGFPGC WKIQIFLFSL FLVIYVLTLL GNGAIIYAVR
CNPLLHTPMY FLLGNFAFLE IWYVSSTIPN MLVNILSKTK AISFSGCFLQ FYFFFSLGTT
ECLFLAVMAY DRYLAICHPL QYPAIMTVRF CGKLVSFCWL IGFLGYPIPI FYISQLPFCG
PNIIDHFLCD MDPLMALSCA PAPITECIFY TQSSLVLFFT SMYILRSYIL LLTAVFQVPS
AAGRRKAFST CGSHLVVVSL FYGTVMVMYV SPTYGIPTLL QKILTLVYSV TTPLFNPLIY
TLRNKDMKLA LRNVLFGMRI RQNS
