O11H6_HUMAN
ID O11H6_HUMAN Reviewed; 330 AA.
AC Q8NGC7; Q6IF08;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 11H6;
DE AltName: Full=Olfactory receptor OR14-35;
GN Name=OR11H6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR11H6";
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DR EMBL; AB065889; BAC06106.1; -; Genomic_DNA.
DR EMBL; BK004454; DAA04852.1; -; Genomic_DNA.
DR CCDS; CCDS32033.1; -.
DR RefSeq; NP_001004480.1; NM_001004480.1.
DR AlphaFoldDB; Q8NGC7; -.
DR SMR; Q8NGC7; -.
DR STRING; 9606.ENSP00000319071; -.
DR GlyGen; Q8NGC7; 1 site.
DR BioMuta; OR11H6; -.
DR DMDM; 38372668; -.
DR MassIVE; Q8NGC7; -.
DR PaxDb; Q8NGC7; -.
DR PeptideAtlas; Q8NGC7; -.
DR PRIDE; Q8NGC7; -.
DR ProteomicsDB; 73477; -.
DR Antibodypedia; 76906; 6 antibodies from 6 providers.
DR DNASU; 122748; -.
DR Ensembl; ENST00000315519.3; ENSP00000319071.2; ENSG00000176219.3.
DR GeneID; 122748; -.
DR KEGG; hsa:122748; -.
DR MANE-Select; ENST00000315519.3; ENSP00000319071.2; NM_001004480.1; NP_001004480.1.
DR UCSC; uc010tlc.3; human.
DR CTD; 122748; -.
DR GeneCards; OR11H6; -.
DR HGNC; HGNC:15349; OR11H6.
DR HPA; ENSG00000176219; Not detected.
DR neXtProt; NX_Q8NGC7; -.
DR PharmGKB; PA32018; -.
DR VEuPathDB; HostDB:ENSG00000176219; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT00940000154475; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGC7; -.
DR OMA; NTTMHFV; -.
DR OrthoDB; 936886at2759; -.
DR PhylomeDB; Q8NGC7; -.
DR TreeFam; TF338968; -.
DR PathwayCommons; Q8NGC7; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 122748; 12 hits in 674 CRISPR screens.
DR GeneWiki; OR11H6; -.
DR GenomeRNAi; 122748; -.
DR Pharos; Q8NGC7; Tdark.
DR PRO; PR:Q8NGC7; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NGC7; protein.
DR Bgee; ENSG00000176219; Expressed in sural nerve and 1 other tissue.
DR ExpressionAtlas; Q8NGC7; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..330
FT /note="Olfactory receptor 11H6"
FT /id="PRO_0000150726"
FT TOPO_DOM 1..43
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..117
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..157
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..215
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..235
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..255
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..276
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 277..289
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 311..330
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 115..207
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 7
FT /note="S -> Y (in dbSNP:rs10140652)"
FT /id="VAR_034299"
FT VARIANT 32
FT /note="L -> V (in dbSNP:rs9323693)"
FT /id="VAR_024130"
FT VARIANT 107
FT /note="I -> T (in dbSNP:rs12891553)"
FT /id="VAR_034300"
FT VARIANT 146
FT /note="R -> H (in dbSNP:rs17106351)"
FT /id="VAR_034301"
FT VARIANT 195
FT /note="L -> F (in dbSNP:rs17211285)"
FT /id="VAR_034302"
FT VARIANT 236
FT /note="Y -> H (in dbSNP:rs17277221)"
FT /id="VAR_034303"
FT VARIANT 259
FT /note="C -> R (in dbSNP:rs17277228)"
FT /id="VAR_034304"
SQ SEQUENCE 330 AA; 36788 MW; 99014E58C6C57110 CRC64;
MFFIIHSLVT SVFLTALGPQ NRTMHFVTEF VLLGFHGQRE MQSCFFSFIL VLYLLTLLGN
GAIVCAVKLD RRLHTPMYIL LGNFAFLEIW YISSTVPNML VNILSEIKTI SFSGCFLQFY
FFFSLGTTEC FFLSVMAYDR YLAICRPLHY PSIMTGKFCI ILVCVCWVGG FLCYPVPIVL
ISQLPFCGPN IIDHLVCDPG PLFALACISA PSTELICYTF NSMIIFGPFL SILGSYTLVI
RAVLCIPSGA GRTKAFSTCG SHLMVVSLFY GTLMVMYVSP TSGNPAGMQK IITLVYTAMT
PFLNPLIYSL RNKDMKDALK RVLGLTVSQN
