ID   ARPIN_XENLA             Reviewed;         227 AA.
AC   Q66IV5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Arpin;
GN   Name=arpin;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates actin polymerization by inhibiting the actin-
CC       nucleating activity of the Arp2/3 complex; the function is competitive
CC       with nucleation promoting factors. Involved in steering cell migration
CC       by controlling its directional persistence (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associates with the Arp2/3 complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium {ECO:0000250}.
CC   -!- DOMAIN: The acidic C-terminus is necessary and sufficient to inhibit
CC       ARP2/3 complex activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Arpin family. {ECO:0000305}.
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DR   EMBL; BC081173; AAH81173.1; -; mRNA.
DR   RefSeq; NP_001087754.1; NM_001094285.1.
DR   AlphaFoldDB; Q66IV5; -.
DR   GeneID; 447578; -.
DR   KEGG; xla:447578; -.
DR   CTD; 447578; -.
DR   OMA; HLMSSYK; -.
DR   OrthoDB; 1458249at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 447578; Expressed in brain and 19 other tissues.
DR   GO; GO:0030027; C:lamellipodium; ISS:UniProtKB.
DR   GO; GO:0033058; P:directional locomotion; ISS:UniProtKB.
DR   GO; GO:0051126; P:negative regulation of actin nucleation; ISS:UniProtKB.
DR   GO; GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:2000393; P:negative regulation of lamellipodium morphogenesis; ISS:UniProtKB.
DR   InterPro; IPR018889; Arpin.
DR   PANTHER; PTHR31199; PTHR31199; 1.
DR   Pfam; PF10574; UPF0552; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Reference proteome.
FT   CHAIN           1..227
FT                   /note="Arpin"
FT                   /id="PRO_0000327662"
FT   REGION          196..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        197..213
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   227 AA;  25714 MW;  0F63EE377D24D5E8 CRC64;
     MSRIYQHTAL QNKPVHDERF DGSWEPGAFQ RGTGVLLEGT LLDFSRHAVT DSKGKKERWY
     ILYLRPSKIH RRHFDSKGNE IEPNFSDTKK VNTGFLMSSY KVEAKGESDR ISLEELNRLV
     NKVNLMKISE KHTPRETVAF WLPEADMEKT ELELGEQLRV KTMGDGPFLF SLAKVDSGTV
     TKCNFAGDAQ AGASWTDNIM ERKSQNTSAP SEPRGQGDGA EDDEWDD