O11HC_HUMAN
ID O11HC_HUMAN Reviewed; 326 AA.
AC B2RN74;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Olfactory receptor 11H12;
GN Name=OR11H12;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR11H12";
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DR EMBL; BC136730; AAI36731.1; -; mRNA.
DR EMBL; BC136731; AAI36732.1; -; mRNA.
DR CCDS; CCDS32017.1; -.
DR RefSeq; NP_001013372.1; NM_001013354.1.
DR AlphaFoldDB; B2RN74; -.
DR SMR; B2RN74; -.
DR BioGRID; 136341; 3.
DR STRING; 9606.ENSP00000449002; -.
DR GlyGen; B2RN74; 3 sites.
DR BioMuta; OR11H12; -.
DR PaxDb; B2RN74; -.
DR PeptideAtlas; B2RN74; -.
DR PRIDE; B2RN74; -.
DR Antibodypedia; 52804; 27 antibodies from 14 providers.
DR DNASU; 440153; -.
DR Ensembl; ENST00000550708.2; ENSP00000449002.1; ENSG00000257115.2.
DR GeneID; 440153; -.
DR KEGG; hsa:440153; -.
DR MANE-Select; ENST00000550708.2; ENSP00000449002.1; NM_001013354.1; NP_001013372.1.
DR UCSC; uc010tkp.3; human.
DR CTD; 440153; -.
DR GeneCards; OR11H12; -.
DR HGNC; HGNC:30738; OR11H12.
DR HPA; ENSG00000257115; Not detected.
DR neXtProt; NX_B2RN74; -.
DR PharmGKB; PA142671220; -.
DR VEuPathDB; HostDB:ENSG00000257115; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT00940000163479; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; B2RN74; -.
DR OMA; VCALWCD; -.
DR OrthoDB; 947860at2759; -.
DR PhylomeDB; B2RN74; -.
DR PathwayCommons; B2RN74; -.
DR SignaLink; B2RN74; -.
DR BioGRID-ORCS; 440153; 16 hits in 571 CRISPR screens.
DR GenomeRNAi; 440153; -.
DR Pharos; B2RN74; Tdark.
DR PRO; PR:B2RN74; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; B2RN74; protein.
DR Bgee; ENSG00000257115; Expressed in endocervix and 2 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..326
FT /note="Olfactory receptor 11H12"
FT /id="PRO_0000344798"
FT TOPO_DOM 1..44
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 66..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..112
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..158
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..216
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 238..259
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..287
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..326
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 13
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 106
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 112..194
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 326 AA; 36530 MW; F616037020AB0550 CRC64;
MCPLTLQVTG LMNVSEPNSS FAFVNEFILQ GFTCEWTIQI FLFSLFTTTY ALTITGNGAI
AFVLWCDWRL HTPMYMFLGN FSFLEIWYVS STVPKMLVNF LSEKKNISFA GCFLQFYFFF
SLGTSECLLL TVMAFDQYLA ICRPLLYPNI MTGHLCAKLV ILCWVCGFLW FLIPIVLISQ
MPFCGPNIID HVVCDPGPRF ALDCVSAPRI QLFCYTLSSL VIFGNFLFII GSYTLVLKAV
LGMPSSTGRH KAFSTCGSHL AVVSLCYSSL MVMYVSPGLG HSTGMQKIET LFYAMVTPLF
NPLIYSLQNK EIKAALRKVL GSSNII
