O11L1_HUMAN
ID O11L1_HUMAN Reviewed; 322 AA.
AC Q8NGX0; B9EIN8;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 11L1;
GN Name=OR11L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=25977809; DOI=10.1038/sdata.2015.2;
RA Mainland J.D., Li Y.R., Zhou T., Liu W.L., Matsunami H.;
RT "Human olfactory receptor responses to odorants.";
RL Sci. Data 2:150002-150002(2015).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR11L1";
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DR EMBL; AB065646; BAC05872.1; -; Genomic_DNA.
DR EMBL; KP290124; ALI87315.1; -; Genomic_DNA.
DR EMBL; CH471148; EAW77204.1; -; Genomic_DNA.
DR EMBL; BC140753; AAI40754.1; -; mRNA.
DR CCDS; CCDS31098.1; -.
DR RefSeq; NP_001001959.1; NM_001001959.1.
DR AlphaFoldDB; Q8NGX0; -.
DR SMR; Q8NGX0; -.
DR STRING; 9606.ENSP00000348033; -.
DR GlyGen; Q8NGX0; 1 site.
DR BioMuta; OR11L1; -.
DR DMDM; 38372779; -.
DR PaxDb; Q8NGX0; -.
DR PeptideAtlas; Q8NGX0; -.
DR PRIDE; Q8NGX0; -.
DR Antibodypedia; 57422; 106 antibodies from 24 providers.
DR DNASU; 391189; -.
DR Ensembl; ENST00000355784.3; ENSP00000348033.2; ENSG00000197591.3.
DR GeneID; 391189; -.
DR KEGG; hsa:391189; -.
DR MANE-Select; ENST00000355784.3; ENSP00000348033.2; NM_001001959.1; NP_001001959.1.
DR UCSC; uc001idn.1; human.
DR CTD; 391189; -.
DR DisGeNET; 391189; -.
DR GeneCards; OR11L1; -.
DR HGNC; HGNC:14998; OR11L1.
DR HPA; ENSG00000197591; Not detected.
DR neXtProt; NX_Q8NGX0; -.
DR PharmGKB; PA32025; -.
DR VEuPathDB; HostDB:ENSG00000197591; -.
DR eggNOG; ENOG502QTTE; Eukaryota.
DR GeneTree; ENSGT01040000240424; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8NGX0; -.
DR OMA; PMYTFLK; -.
DR OrthoDB; 1037233at2759; -.
DR PhylomeDB; Q8NGX0; -.
DR TreeFam; TF336512; -.
DR PathwayCommons; Q8NGX0; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 391189; 11 hits in 678 CRISPR screens.
DR GeneWiki; OR11L1; -.
DR GenomeRNAi; 391189; -.
DR Pharos; Q8NGX0; Tdark.
DR PRO; PR:Q8NGX0; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NGX0; protein.
DR Bgee; ENSG00000197591; Expressed in right lobe of thyroid gland and 1 other tissue.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..322
FT /note="Olfactory receptor 11L1"
FT /id="PRO_0000150727"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..322
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 108
FT /note="G -> S (in dbSNP:rs10888257)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:25977809"
FT /id="VAR_053295"
FT VARIANT 117
FT /note="F -> L (in dbSNP:rs540891010)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:25977809"
FT /id="VAR_034305"
FT VARIANT 142
FT /note="A -> T (in dbSNP:rs10888256)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:25977809"
FT /id="VAR_053296"
FT VARIANT 171
FT /note="R -> P (in dbSNP:rs10888255)"
FT /id="VAR_053297"
SQ SEQUENCE 322 AA; 36763 MW; 9BA9A79E14B3685D CRC64;
MEPQNTSTVT NFQLLGFQNL LEWQALLFVI FLLIYCLTII GNVVIITVVS QGLRLHSPMY
MFLQHLSFLE VWYTSTTVPL LLANLLSWGQ AISFSACMAQ LYFFVFLGAT ECFLLAFMAY
DRYLAICSPL RYPFLMHRGL CARLVVVSWC TGVSTGFLPS LMISRLDFCG RNQINHFFCD
LPPLMQLSCS RVYITEVTIF ILSIAVLCIC FFLTLGPYVF IVSSILRIPS TSGRRKTFST
CGSHLAVVTL YYGTMISMYV CPSPHLLPEI NKIISVFYTV VTPLLNPVIY SLRNKDFKEA
VRKVMRRKCG ILWSTSKRKF LY
