ID   O129B_CONCL             Reviewed;          76 AA.
AC   P0DTX7;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   07-OCT-2020, sequence version 1.
DT   25-MAY-2022, entry version 3.
DE   RecName: Full=Conotoxin Cal29b {ECO:0000305};
DE   AltName: Full=O1_cal29b {ECO:0000303|PubMed:30791616};
DE   Flags: Precursor;
OS   Californiconus californicus (California cone) (Conus californicus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX   NCBI_TaxID=1736779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, FUNCTION, AND
RP   SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=30791616; DOI=10.3390/toxins11020128;
RA   Bernaldez-Sarabia J., Figueroa-Montiel A., Duenas S., Cervantes-Luevano K.,
RA   Beltran J.A., Ortiz E., Jimenez S., Possani L.D., Paniagua-Solis J.F.,
RA   Gonzalez-Canudas J., Licea-Navarro A.;
RT   "The diversified O-superfamily in Californiconus californicus presents a
RT   conotoxin with antimycobacterial activity.";
RL   Toxins 11:1-13(2019).
CC   -!- FUNCTION: Is able to inhibit the growth of Mycobacterium tuberculosis
CC       (MIC=0.22-3.52 uM against strain H37Rv and 2 multidrug-resistant
CC       strains) (PubMed:30791616). May also show neurotoxic activity
CC       (Probable). {ECO:0000269|PubMed:30791616, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30791616}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:30791616}.
CC   -!- DOMAIN: The cysteine framework is XXIX (CCC-C-CC-C-C). {ECO:0000305}.
CC   -!- PTM: May contain 4 disulfide bonds. {ECO:0000305}.
CC   -!- PHARMACEUTICAL: Is a potential drug lead for the treatment of
CC       tuberculosis. {ECO:0000305|PubMed:30791616}.
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0DTX7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Neurotoxin; Pharmaceutical;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..43
FT                   /evidence="ECO:0000255"
FT   CHAIN           44..76
FT                   /note="Conotoxin Cal29b"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000450959"
SQ   SEQUENCE   76 AA;  8185 MW;  7D7E4F4B23395079 CRC64;
     MKLTCVLIVA VLILAACQFT AANMARYGKT QIARSDVKSI DARRPKCCCV CGVVGRKCCS
     TWKDCHPVHL PCPSSG