O12D2_HUMAN
ID O12D2_HUMAN Reviewed; 307 AA.
AC P58182; B0S862; Q5SUN9; Q6IET9;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 09-FEB-2010, sequence version 2.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Olfactory receptor 12D2;
DE AltName: Full=Hs6M1-20;
DE AltName: Full=Olfactory receptor OR6-28;
GN Name=OR12D2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT PHE-104.
RA Janer M.M., Guillaudeux T., Vu Q., Kutyavin T., Harter H., Geraghty D.E.;
RT "Large scale sequence analysis of the human MHC class I region.";
RL Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT PHE-104.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT PHE-104.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PHE-104.
RC TISSUE=Cerebellum;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR12D2";
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DR EMBL; AC004171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL035542; CAB44510.1; -; Genomic_DNA.
DR EMBL; AL645927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662869; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX927232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03191.1; -; Genomic_DNA.
DR EMBL; BC069123; AAH69123.1; -; mRNA.
DR EMBL; BC101742; AAI01743.1; -; mRNA.
DR EMBL; BC101746; AAI01747.1; -; mRNA.
DR EMBL; BK004523; DAA04921.1; -; Genomic_DNA.
DR RefSeq; NP_039224.2; NM_013936.3.
DR AlphaFoldDB; P58182; -.
DR SMR; P58182; -.
DR STRING; 9606.ENSP00000373047; -.
DR GlyGen; P58182; 1 site.
DR iPTMnet; P58182; -.
DR PhosphoSitePlus; P58182; -.
DR BioMuta; OR12D2; -.
DR DMDM; 288558820; -.
DR PaxDb; P58182; -.
DR PRIDE; P58182; -.
DR Antibodypedia; 78438; 9 antibodies from 7 providers.
DR DNASU; 26529; -.
DR Ensembl; ENST00000377140.6; ENSP00000366345.5; ENSG00000204690.6.
DR Ensembl; ENST00000414415.4; ENSP00000414137.3; ENSG00000233481.4.
DR Ensembl; ENST00000438569.4; ENSP00000415065.3; ENSG00000235966.4.
DR Ensembl; ENST00000623183.1; ENSP00000485112.1; ENSG00000280236.3.
DR Ensembl; ENST00000642051.1; ENSP00000493463.1; ENSG00000280236.3.
DR GeneID; 26529; -.
DR KEGG; hsa:26529; -.
DR MANE-Select; ENST00000642051.1; ENSP00000493463.1; NM_013936.4; NP_039224.2.
DR UCSC; uc003nmf.4; human.
DR CTD; 26529; -.
DR GeneCards; OR12D2; -.
DR HGNC; HGNC:8178; OR12D2.
DR HPA; ENSG00000280236; Not detected.
DR neXtProt; NX_P58182; -.
DR OpenTargets; ENSG00000280236; -.
DR PharmGKB; PA32028; -.
DR VEuPathDB; HostDB:ENSG00000280236; -.
DR eggNOG; ENOG502SJ1M; Eukaryota.
DR GeneTree; ENSGT00940000162974; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; P58182; -.
DR OMA; CGNVELN; -.
DR OrthoDB; 1136754at2759; -.
DR PhylomeDB; P58182; -.
DR TreeFam; TF338273; -.
DR PathwayCommons; P58182; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 26529; 5 hits in 663 CRISPR screens.
DR GeneWiki; OR12D2; -.
DR GenomeRNAi; 26529; -.
DR Pharos; P58182; Tdark.
DR PRO; PR:P58182; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; P58182; protein.
DR Bgee; ENSG00000280236; Expressed in hypothalamus and 7 other tissues.
DR ExpressionAtlas; P58182; baseline and differential.
DR Genevisible; P58182; HS.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..307
FT /note="Olfactory receptor 12D2"
FT /id="PRO_0000150728"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..215
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..307
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 47
FT /note="V -> F (in dbSNP:rs9257834)"
FT /id="VAR_057569"
FT VARIANT 56
FT /note="L -> P (in dbSNP:rs4987411)"
FT /id="VAR_057570"
FT VARIANT 104
FT /note="S -> F (in dbSNP:rs3128853)"
FT /evidence="ECO:0000269|PubMed:14574404,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1,
FT ECO:0000269|Ref.3"
FT /id="VAR_058967"
FT VARIANT 113
FT /note="F -> L (in dbSNP:rs2073154)"
FT /id="VAR_057571"
FT VARIANT 120
FT /note="L -> R (in dbSNP:rs2073153)"
FT /id="VAR_057572"
FT VARIANT 121
FT /note="S -> C (in dbSNP:rs2073152)"
FT /id="VAR_057573"
FT VARIANT 132
FT /note="V -> G (in dbSNP:rs11752608)"
FT /id="VAR_057574"
FT VARIANT 159
FT /note="V -> I (in dbSNP:rs2073151)"
FT /id="VAR_057575"
SQ SEQUENCE 307 AA; 34813 MW; 982907668FCFDE8A CRC64;
MLNTTSVTEF LLLGVTDIQE LQPFLFVVFL TIYFISVTGN GAVLMIVISD PRLHSLMYFF
LGNLSYLDIC YSTVTLPKML QNFLSTHKAI SFLGCISQLH FFHSLGSTES MLFAVMAFDL
SVAICKPLRY TVIMNPQLCT QMAITIWVIG FFHALLHSVM TSRLNFCGSN RIHHFLCDIK
PLLKLACGNT ELNQWLLSTV TGTIAMGPFF LTLLSYFYII TYLFFKTRSC SMLCKALSTC
ASHFMVVILF YAPVLFTYIH PALESFMDQD RIVAIMYTVV TPVLNPLIYT LRNKEVKGAL
GRVIRRL
