O12D3_HUMAN
ID O12D3_HUMAN Reviewed; 316 AA.
AC Q9UGF7; A2BDZ1; Q5SQI8; Q6IF23;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=Olfactory receptor 12D3;
DE AltName: Full=Hs6M1-27;
DE AltName: Full=Olfactory receptor OR6-27;
GN Name=OR12D3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=12637542; DOI=10.1074/jbc.m212424200;
RA Volz A., Ehlers A., Younger R., Forbes S., Trowsdale J., Schnorr D.,
RA Beck S., Ziegler A.;
RT "Complex transcription and splicing of odorant receptor genes.";
RL J. Biol. Chem. 278:19691-19701(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ILE-97.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN [6]
RP VARIANT [LARGE SCALE ANALYSIS] LEU-250.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR12D3";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ459858; CAD31041.1; -; mRNA.
DR EMBL; AL096770; CAB65796.1; -; Genomic_DNA.
DR EMBL; AL662781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC069082; AAH69082.1; -; mRNA.
DR EMBL; BC069154; AAH69154.1; -; mRNA.
DR EMBL; BC103892; AAI03893.1; -; mRNA.
DR EMBL; BC106898; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BK004439; DAA04837.1; -; Genomic_DNA.
DR CCDS; CCDS4658.1; -.
DR RefSeq; NP_112221.1; NM_030959.2.
DR AlphaFoldDB; Q9UGF7; -.
DR SMR; Q9UGF7; -.
DR BioGRID; 123588; 6.
DR STRING; 9606.ENSP00000380023; -.
DR GlyGen; Q9UGF7; 1 site.
DR BioMuta; OR12D3; -.
DR DMDM; 14423826; -.
DR PaxDb; Q9UGF7; -.
DR PeptideAtlas; Q9UGF7; -.
DR PRIDE; Q9UGF7; -.
DR Antibodypedia; 35259; 89 antibodies from 21 providers.
DR DNASU; 81797; -.
DR Ensembl; ENST00000383556.7; ENSP00000373048.3; ENSG00000204692.9.
DR Ensembl; ENST00000396806.3; ENSP00000380023.3; ENSG00000112462.8.
DR Ensembl; ENST00000430148.5; ENSP00000393734.1; ENSG00000224487.8.
DR Ensembl; ENST00000505384.5; ENSP00000421215.1; ENSG00000242022.8.
DR Ensembl; ENST00000550681.1; ENSP00000449350.1; ENSG00000204692.9.
DR Ensembl; ENST00000550913.1; ENSP00000447580.1; ENSG00000224487.8.
DR Ensembl; ENST00000552446.1; ENSP00000447204.1; ENSG00000242022.8.
DR GeneID; 81797; -.
DR KEGG; hsa:81797; -.
DR MANE-Select; ENST00000396806.3; ENSP00000380023.3; NM_030959.3; NP_112221.1.
DR UCSC; uc003nme.3; human.
DR CTD; 81797; -.
DR DisGeNET; 81797; -.
DR GeneCards; OR12D3; -.
DR HGNC; HGNC:13963; OR12D3.
DR HPA; ENSG00000112462; Not detected.
DR neXtProt; NX_Q9UGF7; -.
DR OpenTargets; ENSG00000112462; -.
DR PharmGKB; PA32029; -.
DR VEuPathDB; HostDB:ENSG00000112462; -.
DR eggNOG; ENOG502SJ1M; Eukaryota.
DR GeneTree; ENSGT00940000163236; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q9UGF7; -.
DR OMA; MTQDRMV; -.
DR OrthoDB; 1136754at2759; -.
DR PhylomeDB; Q9UGF7; -.
DR TreeFam; TF338273; -.
DR PathwayCommons; Q9UGF7; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 81797; 10 hits in 666 CRISPR screens.
DR GeneWiki; OR12D3; -.
DR GenomeRNAi; 81797; -.
DR Pharos; Q9UGF7; Tdark.
DR PRO; PR:Q9UGF7; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9UGF7; protein.
DR ExpressionAtlas; Q9UGF7; baseline and differential.
DR Genevisible; Q9UGF7; HS.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..316
FT /note="Olfactory receptor 12D3"
FT /id="PRO_0000150729"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..215
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 97
FT /note="T -> I (in dbSNP:rs3749971)"
FT /evidence="ECO:0000269|PubMed:14574404"
FT /id="VAR_020383"
FT VARIANT 250
FT /note="F -> L (in a breast cancer sample; somatic mutation;
FT dbSNP:rs545611345)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036209"
FT VARIANT 277
FT /note="Y -> H (in dbSNP:rs9380122)"
FT /id="VAR_053298"
SQ SEQUENCE 316 AA; 35791 MW; 07FDCF869D8989B2 CRC64;
MENVTTMNEF LLLGLTGVQE LQPFFFGIFL IIYLINLIGN GSILVMVVLE PQLHSPMYFF
LGNLSCLDIS YSSVTLPKLL VNLVCSRRAI SFLGCITQLH FFHFLGSTEA ILLAIMAFDR
FVAICNPLRY TVIMNPQVCI LLAAAAWLIS FFYALMHSVM TAHLSFCGSQ KLNHFFYDVK
PLLELACSDT LLNQWLLSIV TGSISMGAFF LTLLSCFYVI GFLLFKNRSC RILHKALSTC
ASHFMVVCLF YGPVGFTYIR PASATSMIQD RIMAIMYSAV TPVLNPLIYT LRNKEVMMAL
KKIFGRKLFK DWQQHH
