O1312_DANRE
ID O1312_DANRE Reviewed; 325 AA.
AC B3DH96; Q2PRB1;
DT 23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Odorant receptor 131-2 {ECO:0000305};
DE AltName: Full=Odorant receptor family H, subfamily 131, member 2 {ECO:0000312|ZFIN:ZDB-GENE-070806-46};
GN Name=or131-2 {ECO:0000312|EMBL:AAI62686.1,
GN ECO:0000312|Ensembl:ENSDARP00000100978,
GN ECO:0000312|ZFIN:ZDB-GENE-070806-46};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000312|Proteomes:UP000000437};
RN [1] {ECO:0000312|EMBL:ABC43356.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16332259; DOI=10.1186/1471-2164-6-173;
RA Alioto T.S., Ngai J.;
RT "The odorant receptor repertoire of teleost fish.";
RL BMC Genomics 6:173-173(2006).
RN [2] {ECO:0000312|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000312|EMBL:AAI62686.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=21124770; DOI=10.1371/journal.pone.0015027;
RA Leck K.J., Zhang S., Hauser C.A.;
RT "Study of bioengineered zebra fish olfactory receptor 131-2: receptor
RT purification and secondary structure analysis.";
RL PLoS ONE 5:E15027-E15027(2010).
CC -!- FUNCTION: Probable olfactory receptor. {ECO:0000305}.
CC -!- SUBUNIT: Homodimer. Monomer. {ECO:0000269|PubMed:21124770}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21124770};
CC Multi-pass membrane protein {ECO:0000255}. Cytoplasm
CC {ECO:0000269|PubMed:21124770}. Note=Mainly found at the plasma
CC membrane. Also shows punctate cytoplasmic expression.
CC {ECO:0000269|PubMed:21124770}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; DQ306116; ABC43356.1; -; Genomic_DNA.
DR EMBL; CR388163; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC162686; AAI62686.1; -; mRNA.
DR RefSeq; NP_001034727.1; NM_001039638.1.
DR AlphaFoldDB; B3DH96; -.
DR SMR; B3DH96; -.
DR STRING; 7955.ENSDARP00000100978; -.
DR PaxDb; B3DH96; -.
DR Ensembl; ENSDART00000109999; ENSDARP00000100978; ENSDARG00000073812.
DR GeneID; 569405; -.
DR KEGG; dre:569405; -.
DR CTD; 569405; -.
DR ZFIN; ZDB-GENE-070806-46; or91a1p.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000163324; -.
DR InParanoid; B3DH96; -.
DR OrthoDB; 899196at2759; -.
DR PhylomeDB; B3DH96; -.
DR TreeFam; TF332078; -.
DR PRO; PR:B3DH96; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 15.
DR Bgee; ENSDARG00000073812; Expressed in nose epithelium and 1 other tissue.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IDA:UniProtKB.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cytoplasm; Disulfide bond; G-protein coupled receptor;
KW Glycoprotein; Membrane; Olfaction; Receptor; Reference proteome;
KW Sensory transduction; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..325
FT /note="Odorant receptor 131-2"
FT /id="PRO_0000444303"
FT TOPO_DOM 1..22
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 23..43
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..91
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 92..112
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..135
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 136..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..190
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 191..211
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..227
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 228..248
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..267
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 268..285
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..325
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT DISULFID 89..170
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 305
FT /note="C -> Y (in Ref. 1; ABC43356)"
FT /evidence="ECO:0000305"
FT CONFLICT 317
FT /note="R -> G (in Ref. 1; ABC43356)"
FT /evidence="ECO:0000305"
FT CONFLICT 320
FT /note="V -> L (in Ref. 1; ABC43356)"
FT /evidence="ECO:0000305"
FT CONFLICT 323
FT /note="A -> S (in Ref. 1; ABC43356)"
FT /evidence="ECO:0000305"
FT CONFLICT 325
FT /note="Y -> HN (in Ref. 1; ABC43356)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 325 AA; 36713 MW; C97FBAAB710EB904 CRC64;
MNSTSNSSLG NTFISKTLKE KSLTVQVLVG ILLYVNGLMI FTFLKKETFR DTRYILFAQT
LFVDSALMLF ADLTLVGSAY ELFIHIISCY IFCTVMALLS ICSPVTLVAM CLERYVAICL
PLRHASISSP KNTINGLLII WGVSSVIPLF IFIVSFTYTP PNAMNSYVVC SNDVMFQVKW
LAEMRALSQQ LLFVIMLCIV GSTYIKIMVA AKSASAENKK STYKGLRTVI LHGLQLILGM
MQLITPYIDI LTLKVDIMLF INVKFSNFML FWIFPRCLSP LVYGLRDKKF YNALKYYAFC
GIYVCKKHKI KDSKTIRGAV SIAIY
