ID   ARPIN_XENTR             Reviewed;         226 AA.
AC   Q6DJ71;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Arpin;
GN   Name=arpin;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates actin polymerization by inhibiting the actin-
CC       nucleating activity of the Arp2/3 complex; the function is competitive
CC       with nucleation promoting factors. Involved in steering cell migration
CC       by controlling its directional persistence (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associates with the Arp2/3 complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium {ECO:0000250}.
CC   -!- DOMAIN: The acidic C-terminus is necessary and sufficient to inhibit
CC       ARP2/3 complex activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Arpin family. {ECO:0000305}.
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DR   EMBL; BC075312; AAH75312.1; -; mRNA.
DR   RefSeq; NP_001004898.1; NM_001004898.1.
DR   RefSeq; XP_012814274.1; XM_012958820.2.
DR   RefSeq; XP_012814275.1; XM_012958821.2.
DR   AlphaFoldDB; Q6DJ71; -.
DR   STRING; 8364.ENSXETP00000057538; -.
DR   PaxDb; Q6DJ71; -.
DR   DNASU; 448248; -.
DR   GeneID; 448248; -.
DR   KEGG; xtr:448248; -.
DR   CTD; 348110; -.
DR   eggNOG; ENOG502R4IG; Eukaryota.
DR   HOGENOM; CLU_106544_0_0_1; -.
DR   InParanoid; Q6DJ71; -.
DR   OMA; HLMSSYK; -.
DR   OrthoDB; 1458249at2759; -.
DR   PhylomeDB; Q6DJ71; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000012972; Expressed in mesonephros and 13 other tissues.
DR   ExpressionAtlas; Q6DJ71; baseline.
DR   GO; GO:0030027; C:lamellipodium; ISS:UniProtKB.
DR   GO; GO:0033058; P:directional locomotion; ISS:UniProtKB.
DR   GO; GO:0051126; P:negative regulation of actin nucleation; ISS:UniProtKB.
DR   GO; GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:2000393; P:negative regulation of lamellipodium morphogenesis; ISS:UniProtKB.
DR   InterPro; IPR018889; Arpin.
DR   PANTHER; PTHR31199; PTHR31199; 1.
DR   Pfam; PF10574; UPF0552; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Reference proteome.
FT   CHAIN           1..226
FT                   /note="Arpin"
FT                   /id="PRO_0000327663"
FT   REGION          204..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   226 AA;  25505 MW;  830BA42E8998D112 CRC64;
     MSRIYHNTSL RNKPVHDERI AGSWEPTAFQ RGAGVLLEGT LLDFSRHSLT DSKGKKERWY
     ILYLMPSKIH RRHFDSKGNE IEPNFSDTKK VNTGFLMSSY KVEAKGESDK ISVEELIQLV
     NKVELMKISE KYTPRETVAF WLPEVDVEKT ELELGEQLRV KTMGDSPFVF SLAKVDSGTV
     TKCNFAGDAQ AGASWTDNIM AQKSQSTSAC FEPRGQGDGA EDDEWD