O13C5_HUMAN
ID O13C5_HUMAN Reviewed; 318 AA.
AC Q8NGS8; B2RNE5; B9EGW5; Q6IF53;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Olfactory receptor 13C5;
DE AltName: Full=Olfactory receptor OR9-11;
GN Name=OR13C5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR13C5";
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DR EMBL; AB065710; BAC05932.1; -; Genomic_DNA.
DR EMBL; AL450426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136842; AAI36843.1; -; mRNA.
DR EMBL; BC136843; AAI36844.1; -; mRNA.
DR EMBL; BK004409; DAA04807.1; -; Genomic_DNA.
DR CCDS; CCDS35091.1; -.
DR RefSeq; NP_001004482.1; NM_001004482.1.
DR AlphaFoldDB; Q8NGS8; -.
DR SMR; Q8NGS8; -.
DR BioGRID; 126522; 7.
DR IntAct; Q8NGS8; 1.
DR STRING; 9606.ENSP00000363911; -.
DR GlyGen; Q8NGS8; 1 site.
DR iPTMnet; Q8NGS8; -.
DR PhosphoSitePlus; Q8NGS8; -.
DR BioMuta; OR13C5; -.
DR DMDM; 38372765; -.
DR PaxDb; Q8NGS8; -.
DR PeptideAtlas; Q8NGS8; -.
DR PRIDE; Q8NGS8; -.
DR Antibodypedia; 74598; 75 antibodies from 18 providers.
DR DNASU; 138799; -.
DR Ensembl; ENST00000374779.3; ENSP00000363911.2; ENSG00000277556.1.
DR GeneID; 138799; -.
DR KEGG; hsa:138799; -.
DR MANE-Select; ENST00000374779.3; ENSP00000363911.2; NM_001004482.1; NP_001004482.1.
DR UCSC; uc011lvp.2; human.
DR CTD; 138799; -.
DR DisGeNET; 138799; -.
DR GeneCards; OR13C5; -.
DR HGNC; HGNC:15100; OR13C5.
DR HPA; ENSG00000277556; Not detected.
DR neXtProt; NX_Q8NGS8; -.
DR PharmGKB; PA32035; -.
DR VEuPathDB; HostDB:ENSG00000277556; -.
DR eggNOG; ENOG502T9K1; Eukaryota.
DR GeneTree; ENSGT01040000240406; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8NGS8; -.
DR OMA; IFIFYRV; -.
DR OrthoDB; 1006268at2759; -.
DR PhylomeDB; Q8NGS8; -.
DR TreeFam; TF352686; -.
DR PathwayCommons; Q8NGS8; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGS8; -.
DR BioGRID-ORCS; 138799; 10 hits in 588 CRISPR screens.
DR GeneWiki; OR13C5; -.
DR GenomeRNAi; 138799; -.
DR Pharos; Q8NGS8; Tdark.
DR PRO; PR:Q8NGS8; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8NGS8; protein.
DR Bgee; ENSG00000277556; Expressed in ventricular zone and 9 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..318
FT /note="Olfactory receptor 13C5"
FT /id="PRO_0000150734"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..277
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..318
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 18
FT /note="S -> F (in dbSNP:rs1851722)"
FT /id="VAR_053299"
FT VARIANT 32
FT /note="F -> L (in dbSNP:rs6479260)"
FT /id="VAR_034306"
FT VARIANT 69
FT /note="L -> M (in dbSNP:rs7042502)"
FT /id="VAR_060032"
FT VARIANT 86
FT /note="L -> V (in dbSNP:rs4629933)"
FT /id="VAR_060033"
FT VARIANT 117
FT /note="V -> M (in dbSNP:rs2417534)"
FT /id="VAR_060034"
FT VARIANT 189
FT /note="C -> Y (in dbSNP:rs4117966)"
FT /id="VAR_024132"
FT VARIANT 195
FT /note="N -> S (in dbSNP:rs6479259)"
FT /id="VAR_053300"
FT VARIANT 258
FT /note="M -> T (in dbSNP:rs1851724)"
FT /id="VAR_024133"
FT VARIANT 282
FT /note="I -> V (in dbSNP:rs1523678)"
FT /id="VAR_024134"
FT VARIANT 290
FT /note="M -> T (in dbSNP:rs1851725)"
FT /id="VAR_024135"
SQ SEQUENCE 318 AA; 35796 MW; 6865DEBF95217C51 CRC64;
MEWENHTILV EFFLKGLSGH PRLELLFFVL IFIMYVVILL GNGTLILISI LDPHLHTPMY
FFLGNLSFLD ICYTTTSIPS TLVSFLSERK TISLSGCAVQ MFLSLAMGTT ECVLLGVMAF
DRYVAICNPL RYPIIMSKDA YVPMAAGSWI IGAVNSAVQT VFVVQLPFCR NNIINHFTCE
ILAVMKLACA DISGNEFILL VTTTLFLLTP LLLIIVSYTL IILSIFKISS SEGRSKPSST
CSARLTVVIT FCGTIFLMYM KPKSQETLNS DDLDATDKLI FIFYRVMTPM MNPLIYSLRN
KDVKEAVKHL LRRKNFNK
