O13C7_HUMAN
ID O13C7_HUMAN Reviewed; 318 AA.
AC P0DN81;
DT 17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT 17-FEB-2016, sequence version 1.
DT 03-AUG-2022, entry version 21.
DE RecName: Full=Olfactory receptor 13C7;
GN Name=OR13C7 {ECO:0000312|HGNC:HGNC:15102}; Synonyms=OR13C7P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2]
RP POLYMORPHISM.
RX PubMed=22908908; DOI=10.1186/1471-2164-13-414;
RA Olender T., Waszak S.M., Viavant M., Khen M., Ben-Asher E., Reyes A.,
RA Nativ N., Wysocki C.J., Ge D., Lancet D.;
RT "Personal receptor repertoires: olfaction as a model.";
RL BMC Genomics 13:414-414(2012).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- POLYMORPHISM: Segregating pseudogene, locus showing both intact and
CC pseudogene forms in the population. A double nucleotide deletion at
CC position Pro-144 in the gene coding for this protein is responsible for
CC functional diversity, producing a pseudogene.
CC {ECO:0000269|PubMed:22908908}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR13C7P";
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DR EMBL; AL138834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; P0DN81; -.
DR SMR; P0DN81; -.
DR BioMuta; OR13C7; -.
DR MassIVE; P0DN81; -.
DR PRIDE; P0DN81; -.
DR GeneCards; OR13C7; -.
DR HGNC; HGNC:15102; OR13C7.
DR neXtProt; NX_P0DN81; -.
DR Pharos; P0DN81; Tdark.
DR PRO; PR:P0DN81; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P0DN81; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Olfaction; Reference proteome;
KW Sensory transduction; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..318
FT /note="Olfactory receptor 13C7"
FT /id="PRO_0000435455"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..61
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 62..82
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..100
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..181
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 182..202
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..205
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 206..226
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..278
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 279..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..318
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
SQ SEQUENCE 318 AA; 34899 MW; A8DE7BA214757589 CRC64;
MVSANQTASV TEFILLGLSA HPKLEKTFFV LILLMYLVIL LGNGVLILMT VSNSHLHMPM
YFFLGNLSFL DICYTTSSVP LILDSFLTPR KTISFSACAV QMFLSFAMGA TECVLLSMMA
FDRYVAICNP LRYPVVMSKA AYMPKAAGSW VAGSTASMVQ TSLAMRLPFC GDNIINHFTC
EILAVLKLAC ADISVNVISM GVTNVIFLGV PVLFISFSYV FIIATILRIP SAEGRKKAFS
TCSAHLTVVV IFYGTILFMY GKPKSKDPLG ADKQDLADKL ISLFYGVVTP MLNPIIYSLR
NKDVKAAVRD LIFQKCFA
