O13D1_HUMAN
ID O13D1_HUMAN Reviewed; 346 AA.
AC Q8NGV5; B9EIS1; Q6IFL1;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 3.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Olfactory receptor 13D1;
DE AltName: Full=Olfactory receptor OR9-15;
GN Name=OR13D1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS VAL-64; HIS-191 AND
RP LEU-277.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-33 is the initiator.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR13D1";
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DR EMBL; AB065671; BAC05896.1; -; Genomic_DNA.
DR EMBL; AL359846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC140916; AAI40917.1; -; mRNA.
DR EMBL; BK004251; DAA04649.1; -; Genomic_DNA.
DR RefSeq; NP_001004484.1; NM_001004484.1.
DR AlphaFoldDB; Q8NGV5; -.
DR SMR; Q8NGV5; -.
DR STRING; 9606.ENSP00000317357; -.
DR GlyGen; Q8NGV5; 2 sites.
DR PhosphoSitePlus; Q8NGV5; -.
DR BioMuta; OR13D1; -.
DR DMDM; 229462944; -.
DR MassIVE; Q8NGV5; -.
DR PaxDb; Q8NGV5; -.
DR PeptideAtlas; Q8NGV5; -.
DR PRIDE; Q8NGV5; -.
DR Antibodypedia; 29246; 94 antibodies from 22 providers.
DR DNASU; 286365; -.
DR GeneID; 286365; -.
DR KEGG; hsa:286365; -.
DR UCSC; uc011lvs.2; human.
DR CTD; 286365; -.
DR GeneCards; OR13D1; -.
DR HGNC; HGNC:14695; OR13D1.
DR HPA; ENSG00000179055; Not detected.
DR neXtProt; NX_Q8NGV5; -.
DR PharmGKB; PA32040; -.
DR VEuPathDB; HostDB:ENSG00000179055; -.
DR eggNOG; ENOG502SHWR; Eukaryota.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGV5; -.
DR OrthoDB; 1045490at2759; -.
DR PhylomeDB; Q8NGV5; -.
DR TreeFam; TF352686; -.
DR PathwayCommons; Q8NGV5; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 286365; 9 hits in 667 CRISPR screens.
DR GeneWiki; OR13D1; -.
DR GenomeRNAi; 286365; -.
DR Pharos; Q8NGV5; Tdark.
DR PRO; PR:Q8NGV5; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8NGV5; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR InterPro; IPR030787; OR13D1.
DR PANTHER; PTHR26453:SF0; PTHR26453:SF0; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..346
FT /note="Olfactory receptor 13D1"
FT /id="PRO_0000150737"
FT TOPO_DOM 1..57
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..131
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..171
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 193..229
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..249
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 250..269
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..303
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 325..346
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 37
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 300
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 129..221
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 21
FT /note="F -> L (in dbSNP:rs10991359)"
FT /id="VAR_055070"
FT VARIANT 64
FT /note="L -> V (in dbSNP:rs13294411)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_055071"
FT VARIANT 191
FT /note="Q -> H (in dbSNP:rs10820709)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_055072"
FT VARIANT 277
FT /note="S -> L (in dbSNP:rs10761073)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_055073"
SQ SEQUENCE 346 AA; 39125 MW; D7E7908A875922D8 CRC64;
MYRFTDFDVS NISIYLNHVL FYTTQQAGDL EHMETRNYSA MTEFFLVGLS QYPELQLFLF
LLCLIMYMII LLGNSLLIII TILDSRLHTP MYFFLGNLSF LDICYTSSSI PPMLIIFMSE
RKSISFIGCA LQMVVSLGLG STECVLLAVM AYDHYVAICN PLRYSIIMNG VLYVQMAAWS
WIIGCLTSLL QTVLTMMLPF CGNNVIDHIT CEILALLKLV CSDITINVLI MTVTNIVSLV
ILLLLIFISY VFILSSILRI NCAEGRKKAF STCSAHSIVV ILFYGSALFM YMKPKSKNTN
TSDEIIGLSY GVVSPMLNPI IYSLRNKEVK EAVKKVLSRH LHLLKM
