O13F1_HUMAN
ID O13F1_HUMAN Reviewed; 319 AA.
AC Q8NGS4; B9EIM5; Q6IF50;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Olfactory receptor 13F1;
DE AltName: Full=Olfactory receptor OR9-6;
GN Name=OR13F1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS VAL-101; ILE-134 AND
RP MET-254.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR13F1";
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DR EMBL; AB065715; BAC05936.1; -; Genomic_DNA.
DR EMBL; AL450426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC140739; AAI40740.1; -; mRNA.
DR EMBL; BK004412; DAA04810.1; -; Genomic_DNA.
DR CCDS; CCDS35087.1; -.
DR RefSeq; NP_001004485.1; NM_001004485.1.
DR AlphaFoldDB; Q8NGS4; -.
DR SMR; Q8NGS4; -.
DR STRING; 9606.ENSP00000334452; -.
DR GlyGen; Q8NGS4; 1 site.
DR iPTMnet; Q8NGS4; -.
DR PhosphoSitePlus; Q8NGS4; -.
DR BioMuta; OR13F1; -.
DR DMDM; 38372763; -.
DR MassIVE; Q8NGS4; -.
DR PaxDb; Q8NGS4; -.
DR PeptideAtlas; Q8NGS4; -.
DR PRIDE; Q8NGS4; -.
DR ProteomicsDB; 73591; -.
DR Antibodypedia; 57853; 85 antibodies from 20 providers.
DR DNASU; 138805; -.
DR Ensembl; ENST00000334726.3; ENSP00000334452.2; ENSG00000186881.3.
DR GeneID; 138805; -.
DR KEGG; hsa:138805; -.
DR MANE-Select; ENST00000334726.3; ENSP00000334452.2; NM_001004485.1; NP_001004485.1.
DR UCSC; uc011lvm.2; human.
DR CTD; 138805; -.
DR DisGeNET; 138805; -.
DR GeneCards; OR13F1; -.
DR HGNC; HGNC:14723; OR13F1.
DR HPA; ENSG00000186881; Not detected.
DR neXtProt; NX_Q8NGS4; -.
DR PharmGKB; PA32045; -.
DR VEuPathDB; HostDB:ENSG00000186881; -.
DR eggNOG; ENOG502RTW9; Eukaryota.
DR GeneTree; ENSGT00940000162868; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGS4; -.
DR OMA; CAFLIPS; -.
DR OrthoDB; 911615at2759; -.
DR PhylomeDB; Q8NGS4; -.
DR TreeFam; TF352686; -.
DR PathwayCommons; Q8NGS4; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 138805; 10 hits in 667 CRISPR screens.
DR GeneWiki; OR13F1; -.
DR GenomeRNAi; 138805; -.
DR Pharos; Q8NGS4; Tdark.
DR PRO; PR:Q8NGS4; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8NGS4; protein.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..319
FT /note="Olfactory receptor 13F1"
FT /id="PRO_0000150738"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..319
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 18
FT /note="F -> S (in dbSNP:rs7049042)"
FT /id="VAR_034309"
FT VARIANT 94
FT /note="F -> S (in dbSNP:rs7018553)"
FT /id="VAR_034310"
FT VARIANT 101
FT /note="M -> V (in dbSNP:rs1403812)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_024137"
FT VARIANT 134
FT /note="V -> I (in dbSNP:rs1403811)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_053302"
FT VARIANT 254
FT /note="T -> M (in dbSNP:rs7030820)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_034311"
FT VARIANT 270
FT /note="I -> T (in dbSNP:rs7847413)"
FT /id="VAR_053303"
SQ SEQUENCE 319 AA; 35646 MW; E94042C324763A39 CRC64;
MFPANWTSVK VFFFLGFFHY PKVQVIIFAV CLLMYLITLL GNIFLISITI LDSHLHTPMY
LFLSNLSFLD IWYSSSALSP MLANFVSGRN TISFSGCATQ MYLSLAMGST ECVLLPMMAY
DRYVAICNPL RYPVIMNRRT CVQIAAGSWM TGCLTAMVEM MSVLPLSLCG NSIINHFTCE
ILAILKLVCV DTSLVQLIML VISVLLLPMP MLLICISYAF ILASILRISS VEGRSKAFST
CTAHLMVVVL FYGTALSMHL KPSAVDSQEI DKFMALVYAG QTPMLNPIIY SLRNKEVKVA
LKKLLIRNHF NTAFISILK
