O13G1_HUMAN
ID O13G1_HUMAN Reviewed; 307 AA.
AC Q8NGZ3; B2RN80; Q5T2T2; Q6IF86;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Olfactory receptor 13G1;
DE AltName: Full=Olfactory receptor OR1-37;
GN Name=OR13G1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR13G1";
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DR EMBL; AB065623; BAC05849.1; -; Genomic_DNA.
DR EMBL; AL390860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471148; EAW77198.1; -; Genomic_DNA.
DR EMBL; BC136736; AAI36737.1; -; mRNA.
DR EMBL; BC136738; AAI36739.1; -; mRNA.
DR EMBL; BK004376; DAA04774.1; -; Genomic_DNA.
DR CCDS; CCDS31094.1; -.
DR RefSeq; NP_001005487.1; NM_001005487.1.
DR AlphaFoldDB; Q8NGZ3; -.
DR SMR; Q8NGZ3; -.
DR BioGRID; 137889; 24.
DR STRING; 9606.ENSP00000352717; -.
DR GlyGen; Q8NGZ3; 1 site.
DR iPTMnet; Q8NGZ3; -.
DR PhosphoSitePlus; Q8NGZ3; -.
DR BioMuta; OR13G1; -.
DR DMDM; 38372793; -.
DR MassIVE; Q8NGZ3; -.
DR PaxDb; Q8NGZ3; -.
DR PeptideAtlas; Q8NGZ3; -.
DR PRIDE; Q8NGZ3; -.
DR Antibodypedia; 57417; 55 antibodies from 16 providers.
DR DNASU; 441933; -.
DR Ensembl; ENST00000642119.1; ENSP00000493110.1; ENSG00000197437.5.
DR GeneID; 441933; -.
DR KEGG; hsa:441933; -.
DR MANE-Select; ENST00000642119.1; ENSP00000493110.1; NM_001005487.2; NP_001005487.1.
DR UCSC; uc001idi.1; human.
DR CTD; 441933; -.
DR DisGeNET; 441933; -.
DR GeneCards; OR13G1; -.
DR HGNC; HGNC:14999; OR13G1.
DR HPA; ENSG00000197437; Not detected.
DR MIM; 611677; gene.
DR neXtProt; NX_Q8NGZ3; -.
DR OpenTargets; ENSG00000197437; -.
DR PharmGKB; PA32046; -.
DR VEuPathDB; HostDB:ENSG00000197437; -.
DR eggNOG; ENOG502SKP5; Eukaryota.
DR GeneTree; ENSGT00940000162666; -.
DR HOGENOM; CLU_012526_1_3_1; -.
DR InParanoid; Q8NGZ3; -.
DR OMA; VCTTTII; -.
DR OrthoDB; 1115667at2759; -.
DR PhylomeDB; Q8NGZ3; -.
DR TreeFam; TF339741; -.
DR PathwayCommons; Q8NGZ3; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 441933; 12 hits in 679 CRISPR screens.
DR GeneWiki; OR13G1; -.
DR GenomeRNAi; 441933; -.
DR Pharos; Q8NGZ3; Tdark.
DR PRO; PR:Q8NGZ3; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NGZ3; protein.
DR Bgee; ENSG00000197437; Expressed in right testis and 2 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..307
FT /note="Olfactory receptor 13G1"
FT /id="PRO_0000150739"
FT TOPO_DOM 1..22
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..43
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..51
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..96
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..214
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..307
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 94..186
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 46
FT /note="K -> I (in dbSNP:rs28711149)"
FT /id="VAR_062067"
FT VARIANT 132
FT /note="I -> V (in dbSNP:rs1151640)"
FT /id="VAR_048038"
FT VARIANT 146
FT /note="M -> L (in dbSNP:rs28556931)"
FT /id="VAR_062068"
FT VARIANT 224
FT /note="R -> C (in dbSNP:rs28446289)"
FT /id="VAR_062069"
SQ SEQUENCE 307 AA; 34672 MW; 5862C4DBB79414D6 CRC64;
MNHSVVTEFI ILGLTKKPEL QGIIFLFFLI VYLVAFLGNM LIIIAKIYNN TLHTPMYVFL
LTLAVVDIIC TTSIIPKMLG TMLTSENTIS YAGCMSQLFL FTWSLGAEMV LFTTMAYDRY
VAICFPLHYS TIMNHHMCVA LLSMVMAIAV TNSWVHTALI MRLTFCGPNT IDHFFCEIPP
LLALSCSPVR INEVMVYVAD ITLAIGDFIL TCISYGFIIV AILRIRTVEG KRKAFSTCSS
HLTVVTLYYS PVIYTYIRPA SSYTFERDKV VAALYTLVTP TLNPMVYSFQ NREMQAGIRK
VFAFLKH
