O1440_MOUSE
ID O1440_MOUSE Reviewed; 315 AA.
AC Q8VFV4;
DT 03-SEP-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Olfactory receptor 1440;
DE AltName: Full=Olfactory receptor 202-4;
GN Name=Olfr1440; Synonyms=Mor215-1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT of over 400 genes, extensive alternate splicing and unequal expression
RT levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=24361078; DOI=10.1016/j.neuron.2013.10.021;
RA Shirasu M., Yoshikawa K., Takai Y., Nakashima A., Takeuchi H., Sakano H.,
RA Touhara K.;
RT "Olfactory receptor and neural pathway responsible for highly selective
RT sensing of musk odors.";
RL Neuron 81:165-178(2014).
CC -!- FUNCTION: Odorant receptor involved in the detection of muscone.
CC {ECO:0000269|PubMed:24361078}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Localized in the dorsomedial and ventral region of
CC the olfactory bulb. {ECO:0000269|PubMed:24361078}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073411; AAL61074.1; -; Genomic_DNA.
DR EMBL; AY318659; AAP71810.1; -; Genomic_DNA.
DR EMBL; AC129773; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS29629.1; -.
DR RefSeq; NP_666895.1; NM_146684.1.
DR RefSeq; XP_006527169.1; XM_006527106.1.
DR AlphaFoldDB; Q8VFV4; -.
DR SMR; Q8VFV4; -.
DR STRING; 10090.ENSMUSP00000054798; -.
DR PaxDb; Q8VFV4; -.
DR PRIDE; Q8VFV4; -.
DR DNASU; 258679; -.
DR Ensembl; ENSMUST00000054567; ENSMUSP00000054798; ENSMUSG00000046650.
DR Ensembl; ENSMUST00000213657; ENSMUSP00000150691; ENSMUSG00000046650.
DR Ensembl; ENSMUST00000213894; ENSMUSP00000150365; ENSMUSG00000046650.
DR Ensembl; ENSMUST00000216145; ENSMUSP00000150994; ENSMUSG00000046650.
DR Ensembl; ENSMUST00000217062; ENSMUSP00000148978; ENSMUSG00000046650.
DR GeneID; 258679; -.
DR KEGG; mmu:258679; -.
DR UCSC; uc008gty.1; mouse.
DR CTD; 258679; -.
DR MGI; MGI:3031274; Olfr1440.
DR VEuPathDB; HostDB:ENSMUSG00000046650; -.
DR eggNOG; ENOG502SJZ4; Eukaryota.
DR GeneTree; ENSGT01050000244931; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8VFV4; -.
DR OMA; GLFVYMH; -.
DR OrthoDB; 922787at2759; -.
DR PhylomeDB; Q8VFV4; -.
DR TreeFam; TF352753; -.
DR BioGRID-ORCS; 258679; 3 hits in 65 CRISPR screens.
DR PRO; PR:Q8VFV4; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8VFV4; protein.
DR Bgee; ENSMUSG00000046650; Expressed in respiratory tract epithelium and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IDA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..315
FT /note="Olfactory receptor 1440"
FT /id="PRO_0000430080"
FT TOPO_DOM 1..29
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..123
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..143
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..202
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..240
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..272
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..315
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DISULFID 98..180
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 315 AA; 34943 MW; 076297BB63294924 CRC64;
MPGGRNSTVI TKFILVGFSD FPKLKLVLFV IFLGSYLSTV VWNLGLIILI RIDPYLHTPM
YFFLSNLSFL DFCYISSTTP KMLSGFFQKS KSISFVGCTM QYFIFSSLGL SECCLLAAMA
YDRYAAICNP LLYTAIMSPS LCVHMVVGAY STGLLGSLIQ LCAILQLHFC GPNIINHFFC
DLPQLLVLSC SETFPLQVLK FVIAVIFGVA SVIVILISYG YIIGTILNIS SVEGRSKAFN
TCASHLTAVT LFFGSGLFVY MRPSSNSSQG YDKMASVFYT VVIPMLNPLI YSLRNKEIKD
ALQRCKNKCF SQCHC
