O1444_MOUSE
ID O1444_MOUSE Reviewed; 319 AA.
AC Q8VFX2;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Olfactory receptor 1444;
DE AltName: Full=Olfactory receptor 202-4;
GN Name=Olfr1444; Synonyms=Mor202-4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
CC -!- FUNCTION: Potential odorant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073393; AAL61056.1; -; Genomic_DNA.
DR EMBL; AY318663; AAP71814.1; -; Genomic_DNA.
DR CCDS; CCDS29640.1; -.
DR RefSeq; NP_666913.1; NM_146702.1.
DR AlphaFoldDB; Q8VFX2; -.
DR SMR; Q8VFX2; -.
DR STRING; 10090.ENSMUSP00000062460; -.
DR GlyGen; Q8VFX2; 1 site.
DR PhosphoSitePlus; Q8VFX2; -.
DR PaxDb; Q8VFX2; -.
DR PRIDE; Q8VFX2; -.
DR Antibodypedia; 27658; 7 antibodies from 7 providers.
DR DNASU; 258697; -.
DR Ensembl; ENSMUST00000059675; ENSMUSP00000062460; ENSMUSG00000046272.
DR Ensembl; ENSMUST00000213606; ENSMUSP00000150212; ENSMUSG00000046272.
DR GeneID; 258697; -.
DR KEGG; mmu:258697; -.
DR UCSC; uc008gur.1; mouse.
DR CTD; 258697; -.
DR MGI; MGI:3031278; Olfr1444.
DR VEuPathDB; HostDB:ENSMUSG00000046272; -.
DR eggNOG; ENOG502SKXC; Eukaryota.
DR GeneTree; ENSGT01040000240414; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8VFX2; -.
DR OMA; GMMVIIH; -.
DR OrthoDB; 1006246at2759; -.
DR PhylomeDB; Q8VFX2; -.
DR TreeFam; TF352753; -.
DR BioGRID-ORCS; 258697; 1 hit in 66 CRISPR screens.
DR PRO; PR:Q8VFX2; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8VFX2; protein.
DR Bgee; ENSMUSG00000046272; Expressed in spermatocyte.
DR ExpressionAtlas; Q8VFX2; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..319
FT /note="Olfactory receptor 1444"
FT /id="PRO_0000150869"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..319
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 319 AA; 35485 MW; 93DDE1AB6168C6FD CRC64;
MTSMENITEV TEFILLGLTD DPNLQVPLLL IFLFIYLVTL IGNGGMMVII FSDSHLHTPM
YFFLSNLSFV DLGYSSAVAP KMVAALQSGN KVISYNGCAA QFFFFVGFAT VECYLLASMA
YDRHAAVCRP LHYTTTMTTG VCTILTIGSY TCGFLNASIH AADTFKLSFC GSNKINHFFC
DIPPLLALAC SSTHISKLVV FFVVGFNVFF TLLVIIISYF FIYIAIQNMK SSEGRKKAFS
TCASHLTAVS IFYGTIIFMY LQPSSGQSMD TDKIASVFYT VVIPMLNPLI YSLRNREVKS
ALWKILNRFY PASFSVSRK
