O14A2_HUMAN
ID O14A2_HUMAN Reviewed; 314 AA.
AC Q96R54;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Olfactory receptor 14A2;
DE AltName: Full=Olfactory receptor 5AX1;
DE AltName: Full=Olfactory receptor OR1-31;
GN Name=OR14A2; Synonyms=OR5AX1, OR5AX1P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-282.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR14A2";
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DR EMBL; AB065620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF399589; AAK95074.1; -; Genomic_DNA.
DR EMBL; BK004620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS86063.1; -.
DR AlphaFoldDB; Q96R54; -.
DR SMR; Q96R54; -.
DR STRING; 9606.ENSP00000355441; -.
DR GlyGen; Q96R54; 2 sites.
DR BioMuta; OR14A2; -.
DR DMDM; 206558302; -.
DR MassIVE; Q96R54; -.
DR PaxDb; Q96R54; -.
DR PeptideAtlas; Q96R54; -.
DR PRIDE; Q96R54; -.
DR Antibodypedia; 65607; 2 antibodies from 2 providers.
DR Ensembl; ENST00000366485.1; ENSP00000355441.1; ENSG00000241128.2.
DR UCSC; uc057rau.1; human.
DR GeneCards; OR14A2; -.
DR HGNC; HGNC:15024; OR14A2.
DR HPA; ENSG00000241128; Tissue enriched (testis).
DR neXtProt; NX_Q96R54; -.
DR VEuPathDB; HostDB:ENSG00000241128; -.
DR eggNOG; ENOG502SHXQ; Eukaryota.
DR GeneTree; ENSGT01050000244828; -.
DR HOGENOM; CLU_012526_0_1_1; -.
DR InParanoid; Q96R54; -.
DR OMA; AYFVYLK; -.
DR PhylomeDB; Q96R54; -.
DR TreeFam; TF352740; -.
DR PathwayCommons; Q96R54; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q96R54; -.
DR Pharos; Q96R54; Tdark.
DR PRO; PR:Q96R54; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96R54; protein.
DR Bgee; ENSG00000241128; Expressed in left testis and 3 other tissues.
DR ExpressionAtlas; Q96R54; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 14A2"
FT /id="PRO_0000344440"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..91
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 83
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..177
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 314 AA; 34780 MW; 8EE5299FF6898842 CRC64;
MANVTLVTGF LLMGFSNIQK LRILYGVLFL LIYLAALMSN LLIITLITLD VKLQTPMYFF
LKNLSFLDVF LVSVPIPKFI VNNLTHNNSI SILGCAFQLL LMTSFSAGEI FILTAMSYDR
YVAICCPLNY EVIMNTGVCV LMASVSWAIG GLFGTAYTAG TFSMPFCGSS VIPQFFCDVP
SLLRISCSET LMVIYAGIGV GACLSISCFI CIVISYIYIF STVLKIPTTK GQSKAFSTCF
PHLTVFTVFI ITAYFVYLKP PSNSPSVIDR LLSVIYTVMP PVFNPVTYSL RNNDMKCALI
RLLQKTYGQE AYFI
