O14AG_HUMAN
ID O14AG_HUMAN Reviewed; 309 AA.
AC Q8NHC5; Q6IF96;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Olfactory receptor 14A16;
DE AltName: Full=Olfactory receptor 5AT1;
DE AltName: Full=Olfactory receptor OR1-45;
GN Name=OR14A16; Synonyms=OR5AT1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA04764.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR14A16";
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DR EMBL; AB065441; BAC05708.1; -; Genomic_DNA.
DR EMBL; BK004366; DAA04764.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS31097.1; -.
DR RefSeq; NP_001001966.1; NM_001001966.1.
DR AlphaFoldDB; Q8NHC5; -.
DR SMR; Q8NHC5; -.
DR STRING; 9606.ENSP00000350248; -.
DR GlyGen; Q8NHC5; 2 sites.
DR iPTMnet; Q8NHC5; -.
DR PhosphoSitePlus; Q8NHC5; -.
DR BioMuta; OR14A16; -.
DR DMDM; 38372837; -.
DR PaxDb; Q8NHC5; -.
DR PeptideAtlas; Q8NHC5; -.
DR PRIDE; Q8NHC5; -.
DR ProteomicsDB; 73699; -.
DR Antibodypedia; 77890; 10 antibodies from 8 providers.
DR DNASU; 284532; -.
DR Ensembl; ENST00000641093.1; ENSP00000493024.1; ENSG00000196772.5.
DR GeneID; 284532; -.
DR KEGG; hsa:284532; -.
DR MANE-Select; ENST00000641093.1; ENSP00000493024.1; NM_001001966.2; NP_001001966.1.
DR UCSC; uc001idm.1; human.
DR CTD; 284532; -.
DR GeneCards; OR14A16; -.
DR HGNC; HGNC:15022; OR14A16.
DR HPA; ENSG00000196772; Not detected.
DR neXtProt; NX_Q8NHC5; -.
DR OpenTargets; ENSG00000196772; -.
DR PharmGKB; PA162398441; -.
DR VEuPathDB; HostDB:ENSG00000196772; -.
DR eggNOG; ENOG502SKEB; Eukaryota.
DR GeneTree; ENSGT01050000244828; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NHC5; -.
DR OMA; ITITTWA; -.
DR OrthoDB; 876979at2759; -.
DR PhylomeDB; Q8NHC5; -.
DR TreeFam; TF352740; -.
DR PathwayCommons; Q8NHC5; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 284532; 8 hits in 662 CRISPR screens.
DR GeneWiki; OR5AT1; -.
DR GenomeRNAi; 284532; -.
DR Pharos; Q8NHC5; Tdark.
DR PRO; PR:Q8NHC5; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NHC5; protein.
DR Bgee; ENSG00000196772; Expressed in right testis and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 14A16"
FT /id="PRO_0000150581"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..255
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 87
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 238
FT /note="I -> T (in dbSNP:rs6695283)"
FT /id="VAR_043796"
SQ SEQUENCE 309 AA; 34307 MW; C5A4E2C8E8A06A76 CRC64;
MANLTIVTEF ILMGFSTNKN MCILHSILFL LIYLCALMGN VLIIMITTLD HHLHTPVYFF
LKNLSFLDLC LISVTAPKSI ANSLIHNNSI SFLGCVSQVF LLLSSASAEL LLLTVMSFDR
YTAICHPLHY DVIMDRSTCV QRATVSWLYG GLIAVMHTAG TFSLSYCGSN MVHQFFCDIP
QLLAISCSEN LIREIALILI NVVLDFCCFI VIIITYVHVF STVKKIPSTE GQSKAYSICL
PHLLVVLFLS TGFIAYLKPA SESPSILDAV ISVFYTMLPP TFNPIIYSLR NKAIKVALGM
LIKGKLTKK
