O14CZ_HUMAN
ID O14CZ_HUMAN Reviewed; 312 AA.
AC Q8NHC7; Q6IEZ6;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Olfactory receptor 14C36;
DE AltName: Full=Olfactory receptor 5BF1;
DE AltName: Full=Olfactory receptor OR1-59;
GN Name=OR14C36; Synonyms=OR5BF1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR14C36";
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DR EMBL; AB065439; BAC05706.1; -; Genomic_DNA.
DR EMBL; AL450303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004466; DAA04864.1; -; Genomic_DNA.
DR CCDS; CCDS31112.1; -.
DR RefSeq; NP_001001918.1; NM_001001918.1.
DR AlphaFoldDB; Q8NHC7; -.
DR SMR; Q8NHC7; -.
DR BioGRID; 126035; 1.
DR IntAct; Q8NHC7; 1.
DR STRING; 9606.ENSP00000324534; -.
DR GlyGen; Q8NHC7; 1 site.
DR iPTMnet; Q8NHC7; -.
DR PhosphoSitePlus; Q8NHC7; -.
DR BioMuta; OR14C36; -.
DR DMDM; 38503051; -.
DR MassIVE; Q8NHC7; -.
DR MaxQB; Q8NHC7; -.
DR PaxDb; Q8NHC7; -.
DR PRIDE; Q8NHC7; -.
DR Antibodypedia; 57436; 61 antibodies from 17 providers.
DR DNASU; 127066; -.
DR Ensembl; ENST00000317861.1; ENSP00000324534.1; ENSG00000177174.1.
DR GeneID; 127066; -.
DR KEGG; hsa:127066; -.
DR MANE-Select; ENST00000317861.1; ENSP00000324534.1; NM_001001918.1; NP_001001918.1.
DR UCSC; uc010pzl.2; human.
DR CTD; 127066; -.
DR GeneCards; OR14C36; -.
DR HGNC; HGNC:15026; OR14C36.
DR HPA; ENSG00000177174; Not detected.
DR neXtProt; NX_Q8NHC7; -.
DR OpenTargets; ENSG00000177174; -.
DR PharmGKB; PA162398442; -.
DR VEuPathDB; HostDB:ENSG00000177174; -.
DR eggNOG; ENOG502SHXQ; Eukaryota.
DR GeneTree; ENSGT01040000240424; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8NHC7; -.
DR OMA; RIFYSEN; -.
DR OrthoDB; 1077347at2759; -.
DR PhylomeDB; Q8NHC7; -.
DR TreeFam; TF337248; -.
DR PathwayCommons; Q8NHC7; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NHC7; -.
DR BioGRID-ORCS; 127066; 12 hits in 681 CRISPR screens.
DR GeneWiki; OR5BF1; -.
DR GenomeRNAi; 127066; -.
DR Pharos; Q8NHC7; Tdark.
DR PRO; PR:Q8NHC7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NHC7; protein.
DR Bgee; ENSG00000177174; Expressed in hypothalamus and 2 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 14C36"
FT /id="PRO_0000150589"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 141
FT /note="Q -> R (in dbSNP:rs28448343)"
FT /id="VAR_062070"
FT VARIANT 225
FT /note="G -> R (in dbSNP:rs28377739)"
FT /id="VAR_062071"
FT VARIANT 231
FT /note="D -> Y (in dbSNP:rs28545014)"
FT /id="VAR_062072"
SQ SEQUENCE 312 AA; 34815 MW; 652D51698C971521 CRC64;
MPNSTTVMEF LLMRFSDVWT LQILHSASFF MLYLVTLMGN ILIVTVTTCD SSLHMPMYFF
LRNLSILDAC YISVTVPTSC VNSLLDSTTI SKAGCVAQVF LVVFFVYVEL LFLTIMAHDR
YVAVCQPLHY PVIVNSRICI QMTLASLLSG LVYAGMHTGS TFQLPFCRSN VIHQFFCDIP
SLLKLSCSDT FSNEVMIVVS ALGVGGGCFI FIIRSYIHIF STVLGFPRGA DRTKAFSTCI
PHILVVSVFL SSCSSVYLRP PAIPAATQDL ILSGFYSIMP PLFNPIIYSL RNKQIKVAIK
KIMKRIFYSE NV
