O14I1_HUMAN
ID O14I1_HUMAN Reviewed; 311 AA.
AC A6ND48; B2RNZ0;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Olfactory receptor 14I1;
DE AltName: Full=Olfactory receptor 5BU1;
GN Name=OR14I1; Synonyms=OR5BU1, OR5BU1P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-36; ASN-50 AND ASN-170.
RX PubMed=25977809; DOI=10.1038/sdata.2015.2;
RA Mainland J.D., Li Y.R., Zhou T., Liu W.L., Matsunami H.;
RT "Human olfactory receptor responses to odorants.";
RL Sci. Data 2:150002-150002(2015).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS ALA-36; ASN-50
RP AND ASN-170.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ALA-36; ASN-50 AND
RP ASN-170.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- INTERACTION:
CC A6ND48; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-13413682, EBI-11959885;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR14I1";
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DR EMBL; KP290503; ALI87665.1; -; Genomic_DNA.
DR EMBL; AC098483; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471257; EAW57530.1; -; Genomic_DNA.
DR EMBL; BC137188; AAI37189.1; -; mRNA.
DR EMBL; BC137189; AAI37190.1; -; mRNA.
DR CCDS; CCDS31125.1; -.
DR RefSeq; NP_001004734.1; NM_001004734.1.
DR RefSeq; XP_005273189.1; XM_005273132.3.
DR AlphaFoldDB; A6ND48; -.
DR SMR; A6ND48; -.
DR BioGRID; 135302; 31.
DR IntAct; A6ND48; 2.
DR STRING; 9606.ENSP00000339726; -.
DR GlyGen; A6ND48; 1 site.
DR iPTMnet; A6ND48; -.
DR PhosphoSitePlus; A6ND48; -.
DR BioMuta; OR14I1; -.
DR MassIVE; A6ND48; -.
DR PaxDb; A6ND48; -.
DR PRIDE; A6ND48; -.
DR Antibodypedia; 74074; 18 antibodies from 10 providers.
DR DNASU; 401994; -.
DR Ensembl; ENST00000342623.5; ENSP00000339726.3; ENSG00000189181.5.
DR GeneID; 401994; -.
DR KEGG; hsa:401994; -.
DR UCSC; uc001ieu.1; human.
DR CTD; 401994; -.
DR GeneCards; OR14I1; -.
DR HGNC; HGNC:19575; OR14I1.
DR HPA; ENSG00000189181; Not detected.
DR MIM; 618516; gene.
DR neXtProt; NX_A6ND48; -.
DR OpenTargets; ENSG00000189181; -.
DR PharmGKB; PA162398443; -.
DR VEuPathDB; HostDB:ENSG00000189181; -.
DR eggNOG; ENOG502SHXQ; Eukaryota.
DR GeneTree; ENSGT01050000244828; -.
DR HOGENOM; CLU_012526_0_1_1; -.
DR InParanoid; A6ND48; -.
DR OMA; PQLIVIM; -.
DR OrthoDB; 876979at2759; -.
DR PhylomeDB; A6ND48; -.
DR TreeFam; TF352740; -.
DR PathwayCommons; A6ND48; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; A6ND48; -.
DR BioGRID-ORCS; 401994; 13 hits in 674 CRISPR screens.
DR ChiTaRS; OR14I1; human.
DR GenomeRNAi; 401994; -.
DR Pharos; A6ND48; Tdark.
DR PRO; PR:A6ND48; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; A6ND48; protein.
DR Bgee; ENSG00000189181; Expressed in prefrontal cortex and 19 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 14I1"
FT /id="PRO_0000310414"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..92
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..189
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..241
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 36
FT /note="V -> A (in dbSNP:rs4462184)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:25977809, ECO:0000269|Ref.3"
FT /id="VAR_037030"
FT VARIANT 50
FT /note="D -> N (in dbSNP:rs4509608)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:25977809, ECO:0000269|Ref.3"
FT /id="VAR_037031"
FT VARIANT 84
FT /note="L -> M (in dbSNP:rs41311583)"
FT /id="VAR_062073"
FT VARIANT 170
FT /note="S -> N (in dbSNP:rs2000390)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:25977809, ECO:0000269|Ref.3"
FT /id="VAR_037032"
FT VARIANT 216
FT /note="Y -> C (in dbSNP:rs55871516)"
FT /id="VAR_062074"
SQ SEQUENCE 311 AA; 35175 MW; 2AC007546D7A9C59 CRC64;
MDNLTKVTEF LLMEFSGIWE LQVLHAGLFL LIYLAVLVGN LLIIAVITLD QHLHTPMYFF
LKNLSVLDLC YISVTVPKSI RNSLTRRSSI SYLGCVAQVY FFSAFASAEL AFLTVMSYDR
YVAICHPLQY RAVMTSGGCY QMAVTTWLSC FSYAAVHTGN MFREHVCRSS VIHQFFRDIP
HVLALVSCEV FFVEFLTLAL SSCLVLGCFI LMMISYFQIF STVLRIPSGQ SRAKAFSTCS
PQLIVIMLFL TTGLFAALGP IAKALSIQDL VIALTYTVLP PFLNPIIYSL RNKEIKTAMW
RLFVKIYFLQ K
