O14J1_HUMAN
ID O14J1_HUMAN Reviewed; 321 AA.
AC Q9UGF5; A2BEC2; B0V078; Q5ST27;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Olfactory receptor 14J1;
DE AltName: Full=Hs6M1-28;
DE AltName: Full=Olfactory receptor 5U1;
DE AltName: Full=Olfactory receptor OR6-25;
GN Name=OR14J1; Synonyms=OR5U1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT THR-7.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR14J1";
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DR EMBL; AL096770; CAB65799.1; -; Genomic_DNA.
DR EMBL; AL662857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX005432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR753509; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR936918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX927232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136905; AAI36906.1; -; mRNA.
DR EMBL; BK004441; DAA04839.1; -; Genomic_DNA.
DR CCDS; CCDS34362.1; -.
DR RefSeq; NP_112208.1; NM_030946.1.
DR AlphaFoldDB; Q9UGF5; -.
DR SMR; Q9UGF5; -.
DR BioGRID; 138088; 3.
DR STRING; 9606.ENSP00000366365; -.
DR GlyGen; Q9UGF5; 1 site.
DR BioMuta; OR14J1; -.
DR DMDM; 14423824; -.
DR PaxDb; Q9UGF5; -.
DR PeptideAtlas; Q9UGF5; -.
DR PRIDE; Q9UGF5; -.
DR ProteomicsDB; 84211; -.
DR Antibodypedia; 50346; 90 antibodies from 23 providers.
DR DNASU; 442191; -.
DR Ensembl; ENST00000230221.5; ENSP00000230221.4; ENSG00000112459.5.
DR Ensembl; ENST00000377160.4; ENSP00000366365.2; ENSG00000204695.4.
DR Ensembl; ENST00000420495.4; ENSP00000389802.3; ENSG00000236927.4.
DR Ensembl; ENST00000421489.4; ENSP00000403553.3; ENSG00000234195.4.
DR Ensembl; ENST00000434778.4; ENSP00000398851.3; ENSG00000225291.4.
DR Ensembl; ENST00000435798.4; ENSP00000400501.3; ENSG00000234100.4.
DR Ensembl; ENST00000451272.4; ENSP00000408647.3; ENSG00000237777.4.
DR Ensembl; ENST00000641895.1; ENSP00000492893.1; ENSG00000204695.4.
DR GeneID; 442191; -.
DR KEGG; hsa:442191; -.
DR MANE-Select; ENST00000641895.1; ENSP00000492893.1; NM_030946.2; NP_112208.1.
DR UCSC; uc011dln.2; human.
DR CTD; 442191; -.
DR DisGeNET; 442191; -.
DR GeneCards; OR14J1; -.
DR HGNC; HGNC:13971; OR14J1.
DR HPA; ENSG00000204695; Tissue enhanced (brain, retina).
DR neXtProt; NX_Q9UGF5; -.
DR OpenTargets; ENSG00000204695; -.
DR PharmGKB; PA162398444; -.
DR VEuPathDB; HostDB:ENSG00000204695; -.
DR eggNOG; ENOG502SHXQ; Eukaryota.
DR GeneTree; ENSGT01050000244828; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q9UGF5; -.
DR OMA; SAMDLMF; -.
DR OrthoDB; 876979at2759; -.
DR PhylomeDB; Q9UGF5; -.
DR TreeFam; TF352740; -.
DR PathwayCommons; Q9UGF5; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 442191; 7 hits in 672 CRISPR screens.
DR GeneWiki; OR5U1; -.
DR GenomeRNAi; 442191; -.
DR Pharos; Q9UGF5; Tdark.
DR PRO; PR:Q9UGF5; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9UGF5; protein.
DR Bgee; ENSG00000204695; Expressed in testis and 2 other tissues.
DR ExpressionAtlas; Q9UGF5; baseline and differential.
DR Genevisible; Q9UGF5; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..321
FT /note="Olfactory receptor 14J1"
FT /id="PRO_0000150616"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 7
FT /note="M -> T (in dbSNP:rs9257694)"
FT /evidence="ECO:0000269|PubMed:14574404"
FT /id="VAR_034234"
FT VARIANT 278
FT /note="V -> M (in dbSNP:rs17404424)"
FT /id="VAR_034235"
SQ SEQUENCE 321 AA; 35892 MW; 69B33B0A14F49772 CRC64;
MVNLTSMSGF LLMGFSDERK LQILHALVFL VTYLLALTGN LLIITIITVD RRLHSPMYYF
LKHLSLLDLC FISVTVPQSI ANSLMGNGYI SLVQCILQVF FFIALASSEV AILTVMSYDR
YAAICQPLHY ETIMDPRACR HAVIAVWIAG GLSGLMHAAI NFSIPLCGKR VIHQFFCDVP
QMLKLACSYE FINEIALAAF TTSAAFICLI SIVLSYIRIF STVLRIPSAE GRTKVFSTCL
PHLFVATFFL SAAGFEFLRL PSDSSSTVDL VFSVFYTVIP PTLNPVIYSL RNDSMKAALR
KMLSKEELPQ RKMCLKAMFK L
