O1509_MOUSE
ID O1509_MOUSE Reviewed; 308 AA.
AC Q7TQQ0; A0A0U1RP41; Q9R0K3;
DT 18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Olfactory receptor 1509 {ECO:0000305};
DE AltName: Full=Odorant receptor 244-3 {ECO:0000303|PubMed:18214836, ECO:0000303|PubMed:22328155, ECO:0000303|PubMed:25185561, ECO:0000303|PubMed:25901328, ECO:0000303|PubMed:27019154};
DE AltName: Full=Odorant receptor 83 {ECO:0000303|PubMed:10493742};
GN Name=Olfr1509 {ECO:0000312|MGI:MGI:3031343};
GN Synonyms=MOR244-3 {ECO:0000303|PubMed:18214836,
GN ECO:0000303|PubMed:22328155, ECO:0000303|PubMed:25185561,
GN ECO:0000312|MGI:MGI:3031343}, MOR83 {ECO:0000303|PubMed:10493742,
GN ECO:0000312|MGI:MGI:3031343};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|EMBL:AAP71857.1};
RN [1] {ECO:0000312|EMBL:BAA86125.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=129/SvJ {ECO:0000312|EMBL:BAA86125.1};
RX PubMed=10493742; DOI=10.1523/jneurosci.19-19-08409.1999;
RA Tsuboi A., Yoshihara S., Yamazaki N., Kasai H., Asai-Tsuboi H., Komatsu M.,
RA Serizawa S., Ishii T., Matsuda Y., Nagawa F., Sakano H.;
RT "Olfactory neurons expressing closely linked and homologous odorant
RT receptor genes tend to project their axons to neighboring glomeruli on the
RT olfactory bulb.";
RL J. Neurosci. 19:8409-8418(1999).
RN [2] {ECO:0000312|EMBL:AAL60958.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [4] {ECO:0000312|EMBL:AAP71857.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT of over 400 genes, extensive alternate splicing and unequal expression
RT levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [5] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [6] {ECO:0000312|EMBL:EDL42235.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000312|EMBL:AAI19196.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8] {ECO:0000305}
RP FUNCTION, ACTIVITY REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP AND MUTAGENESIS OF HIS-56; MET-59; HIS-73; CYS-97; HIS-105; CYS-109;
RP MET-118; CYS-127; MET-136; CYS-141; HIS-155; CYS-169; CYS-179; CYS-189;
RP CYS-210; HIS-243; CYS-254; MET-298; HIS-300 AND CYS-307.
RX PubMed=22328155; DOI=10.1073/pnas.1111297109;
RA Duan X., Block E., Li Z., Connelly T., Zhang J., Huang Z., Su X., Pan Y.,
RA Wu L., Chi Q., Thomas S., Zhang S., Ma M., Matsunami H., Chen G.Q.,
RA Zhuang H.;
RT "Crucial role of copper in detection of metal-coordinating odorants.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:3492-3497(2012).
RN [9] {ECO:0000305}
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=18214836; DOI=10.1002/dneu.20612;
RA Tian H., Ma M.;
RT "Differential development of odorant receptor expression patterns in the
RT olfactory epithelium: a quantitative analysis in the mouse septal organ.";
RL Dev. Neurobiol. 68:476-486(2008).
RN [10] {ECO:0000305}
RP FUNCTION, ACTIVITY REGULATION, SUBCELLULAR LOCATION, AND MUTAGENESIS OF
RP CYS-109.
RX PubMed=25185561; DOI=10.1016/j.bpj.2014.07.031;
RA Sekharan S., Ertem M.Z., Zhuang H., Block E., Matsunami H., Zhang R.,
RA Wei J.N., Pan Y., Batista V.S.;
RT "QM/MM model of the mouse olfactory receptor MOR244-3 validated by site-
RT directed mutagenesis experiments.";
RL Biophys. J. 107:L5-L8(2014).
RN [11] {ECO:0000305}
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=25901328; DOI=10.1073/pnas.1503054112;
RA Block E., Jang S., Matsunami H., Sekharan S., Dethier B., Ertem M.Z.,
RA Gundala S., Pan Y., Li S., Li Z., Lodge S.N., Ozbil M., Jiang H.,
RA Penalba S.F., Batista V.S., Zhuang H.;
RT "Implausibility of the vibrational theory of olfaction.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:E2766-E2774(2015).
RN [12] {ECO:0000305}
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=27019154; DOI=10.1016/j.ab.2016.03.006;
RA Burger J.L., Jeerage K.M., Bruno T.J.;
RT "Direct nuclear magnetic resonance observation of odorant binding to mouse
RT odorant receptor MOR244-3.";
RL Anal. Biochem. 502:64-72(2016).
RN [13] {ECO:0000305}
RP FUNCTION, ACTIVITY REGULATION, SUBCELLULAR LOCATION, AND MUTAGENESIS OF
RP CYS-254; ARG-260 AND LYS-269.
RX PubMed=29659735; DOI=10.1093/chemse/bjy022;
RA Zhang R., Pan Y., Ahmed L., Block E., Zhang Y., Batista V.S., Zhuang H.;
RT "A Multispecific Investigation of the Metal Effect in Mammalian Odorant
RT Receptors for Sulfur-containing Compounds.";
RL Chem. Senses 43:357-366(2018).
CC -!- FUNCTION: Olfactory receptor that is activated by the binding of
CC organosulfur odorants with thioether groups such as
CC (methylthio)methanethiol (MTMT) and bis(methylthiomethyl) disulfide
CC (PubMed:22328155, PubMed:25185561, PubMed:25901328, PubMed:29659735).
CC Also binds odorants cis-cyclooctene and tert-butyl mercaptan
CC (PubMed:27019154). The activity of this receptor is mediated by G
CC proteins which activate adenylyl cyclase (Potential).
CC {ECO:0000269|PubMed:22328155, ECO:0000269|PubMed:25185561,
CC ECO:0000269|PubMed:25901328, ECO:0000269|PubMed:27019154,
CC ECO:0000269|PubMed:29659735, ECO:0000305}.
CC -!- ACTIVITY REGULATION: Copper binding enhances receptor activity in
CC response to odorant binding. {ECO:0000269|PubMed:22328155,
CC ECO:0000269|PubMed:25185561, ECO:0000269|PubMed:29659735}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255,
CC ECO:0000255|RuleBase:RU363047, ECO:0000269|PubMed:22328155,
CC ECO:0000269|PubMed:27019154, ECO:0000269|PubMed:29659735,
CC ECO:0000305|PubMed:25185561, ECO:0000305|PubMed:25901328}; Multi-pass
CC membrane protein {ECO:0000255, ECO:0000255|RuleBase:RU363047,
CC ECO:0000269|PubMed:27019154}.
CC -!- TISSUE SPECIFICITY: Expressed in olfactory epithelium, specifically in
CC the olfactory sensory neurons of the septal organ.
CC {ECO:0000269|PubMed:10493742, ECO:0000269|PubMed:18214836,
CC ECO:0000269|PubMed:22328155}.
CC -!- DEVELOPMENTAL STAGE: Detected at very low levels at 18 dpc and
CC increased to its maximum level of expression by 7 days after birth in
CC olfactory sensory neurons of the septal organ.
CC {ECO:0000269|PubMed:18214836}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255, ECO:0000255|RuleBase:RU000688}.
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DR EMBL; AB030894; BAA86125.1; -; Genomic_DNA.
DR EMBL; AY073295; AAL60958.1; -; Genomic_DNA.
DR EMBL; AY318728; AAP71857.1; -; Genomic_DNA.
DR EMBL; AC126025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466659; EDL42235.1; -; Genomic_DNA.
DR EMBL; BC119195; AAI19196.1; -; mRNA.
DR EMBL; BC119199; AAI19200.1; -; mRNA.
DR CCDS; CCDS27060.1; -.
DR RefSeq; NP_065260.2; NM_020514.2.
DR AlphaFoldDB; Q7TQQ0; -.
DR SMR; Q7TQQ0; -.
DR STRING; 10090.ENSMUSP00000046688; -.
DR GlyGen; Q7TQQ0; 1 site.
DR iPTMnet; Q7TQQ0; -.
DR PhosphoSitePlus; Q7TQQ0; -.
DR PaxDb; Q7TQQ0; -.
DR PRIDE; Q7TQQ0; -.
DR Antibodypedia; 58801; 40 antibodies from 14 providers.
DR DNASU; 57271; -.
DR Ensembl; ENSMUST00000045066; ENSMUSP00000046688; ENSMUSG00000035626.
DR Ensembl; ENSMUST00000205900; ENSMUSP00000145819; ENSMUSG00000035626.
DR Ensembl; ENSMUST00000206100; ENSMUSP00000146173; ENSMUSG00000035626.
DR Ensembl; ENSMUST00000215030; ENSMUSP00000150016; ENSMUSG00000035626.
DR GeneID; 57271; -.
DR KEGG; mmu:57271; -.
DR UCSC; uc007tpl.2; mouse.
DR CTD; 57271; -.
DR MGI; MGI:3031343; Olfr1509.
DR VEuPathDB; HostDB:ENSMUSG00000035626; -.
DR eggNOG; ENOG502RCGN; Eukaryota.
DR GeneTree; ENSGT00940000163275; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q7TQQ0; -.
DR OMA; TLNQTRV; -.
DR OrthoDB; 1010638at2759; -.
DR PhylomeDB; Q7TQQ0; -.
DR TreeFam; TF337251; -.
DR BioGRID-ORCS; 57271; 1 hit in 65 CRISPR screens.
DR ChiTaRS; Olfr1509; mouse.
DR PRO; PR:Q7TQQ0; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q7TQQ0; protein.
DR Bgee; ENSMUSG00000035626; Expressed in vomeronasal organ and 10 other tissues.
DR ExpressionAtlas; Q7TQQ0; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IMP:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
DR GO; GO:0005507; F:copper ion binding; IMP:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IDA:UniProtKB.
DR GO; GO:0004984; F:olfactory receptor activity; IDA:UniProtKB.
DR GO; GO:0050907; P:detection of chemical stimulus involved in sensory perception; IDA:UniProtKB.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IDA:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Copper; Disulfide bond; G-protein coupled receptor;
KW Glycoprotein; Membrane; Metal-binding; Olfaction; Receptor;
KW Reference proteome; Sensory transduction; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..308
FT /note="Olfactory receptor 1509"
FT /id="PRO_0000444894"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 25..45
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..97
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..204
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 205..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..268
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..308
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT BINDING 105
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000305|PubMed:22328155,
FT ECO:0000305|PubMed:25185561"
FT BINDING 109
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000305|PubMed:25185561"
FT BINDING 260
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000305|PubMed:29659735"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT MUTAGEN 56
FT /note="H->K: Decreased receptor activity in response to
FT MTMT binding, even in the presence of copper."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 59
FT /note="M->A: Decreased receptor activity in response to
FT MTMT binding, even in the presence of copper."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 73
FT /note="H->A,K,R: No receptor activity in response to MTMT
FT binding, even in the presence of copper."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 73
FT /note="H->F,Y: No change in receptor activity in response
FT to MTMT binding. No change in the copper-induced
FT enhancement of receptor activity."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 97
FT /note="C->A,V: No receptor activity in response to MTMT
FT binding, even in the presence of copper."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 97
FT /note="C->S: No receptor activity in response to MTMT
FT binding, even in the presence of copper. Little to no
FT expression detected on plasma membrane."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 105
FT /note="H->A,L,R: No receptor activity in response to MTMT
FT binding, even in the presence of copper."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 105
FT /note="H->K: Decreased receptor activity in response to
FT MTMT binding, even in the presence of copper. Complete loss
FT of receptor activity in the absence of copper."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 109
FT /note="C->M: Decreased receptor activity in response to
FT MTMT binding, even in the presence of copper. Shows low
FT constitutive activity in the presence of copper. MTMT
FT binding in the absence of copper results in an inverse
FT agonist effect."
FT /evidence="ECO:0000269|PubMed:25185561"
FT MUTAGEN 109
FT /note="C->V: Decreased receptor activity in response to
FT MTMT binding, even in the presence of copper. Complete loss
FT of receptor activity in the absence of copper."
FT /evidence="ECO:0000269|PubMed:22328155,
FT ECO:0000269|PubMed:25185561"
FT MUTAGEN 118
FT /note="M->A: Decreased receptor activity in response to
FT MTMT binding, even in the presence of copper. Complete loss
FT of receptor activity in the absence of copper."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 127
FT /note="C->V: Decreased receptor activity in response to
FT MTMT binding, even in the presence of copper."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 136
FT /note="M->A: Decreased receptor activity in response to
FT MTMT binding, even in the presence of copper. Complete loss
FT of receptor activity in the absence of copper."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 141
FT /note="C->V: Decreased receptor activity in response to
FT MTMT binding, even in the presence of copper. Complete loss
FT of receptor activity in the absence of copper."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 155
FT /note="H->A,K,N,V: No receptor activity in response to MTMT
FT binding, even in the presence of copper."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 155
FT /note="H->R: No receptor activity in response to MTMT
FT binding, even in the presence of copper. Little to no
FT expression detected on plasma membrane."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 169
FT /note="C->A,F,V: No receptor activity in response to MTMT
FT binding, even in the presence of copper."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 169
FT /note="C->S: No receptor activity in response to MTMT
FT binding, even in the presence of copper. Little to no
FT expression detected on plasma membrane."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 179
FT /note="C->A,V: No receptor activity in response to MTMT
FT binding, even in the presence of copper."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 179
FT /note="C->S: No receptor activity in response to MTMT
FT binding, even in the presence of copper. Little to no
FT expression detected on plasma membrane."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 189
FT /note="C->A,V: No receptor activity in response to MTMT
FT binding, even in the presence of copper."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 189
FT /note="C->S: Decreased receptor activity in response to
FT MTMT binding, even in the presence of copper. Complete loss
FT of receptor activity in the absence of copper."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 210
FT /note="C->A: No change in receptor activity in response to
FT MTMT binding in the presence of copper. Decreased receptor
FT activity in the absence of copper."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 210
FT /note="C->S: No change in receptor activity in response to
FT MTMT binding in the presence of copper. Complete loss of
FT receptor activity in the absence of copper."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 210
FT /note="C->V: No receptor activity in response to MTMT
FT binding, even in the presence of copper."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 243
FT /note="H->A,K: No receptor activity in response to MTMT
FT binding, even in the presence of copper."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 243
FT /note="H->R: No receptor activity in response to MTMT
FT binding, even in the presence of copper. Little to no
FT expression detected on plasma membrane."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 254
FT /note="C->V,S: Decreased receptor activity in response to
FT MTMT binding, even in the presence of copper. Complete loss
FT of receptor activity in the absence of copper."
FT /evidence="ECO:0000269|PubMed:22328155,
FT ECO:0000269|PubMed:29659735"
FT MUTAGEN 260
FT /note="R->H: Decreased receptor activity in response to
FT MTMT binding, even in the presence of copper."
FT /evidence="ECO:0000269|PubMed:29659735"
FT MUTAGEN 260
FT /note="R->W,A: No receptor activity in response to MTMT
FT binding, even in the presence of copper."
FT /evidence="ECO:0000269|PubMed:29659735"
FT MUTAGEN 269
FT /note="K->A: Decreased receptor activity in response to
FT MTMT binding, even in the presence of copper."
FT /evidence="ECO:0000269|PubMed:29659735"
FT MUTAGEN 269
FT /note="K->H: No receptor activity in response to MTMT
FT binding, even in the presence of copper."
FT /evidence="ECO:0000269|PubMed:29659735"
FT MUTAGEN 298
FT /note="M->A: Decreased receptor activity in response to
FT MTMT binding, even in the presence of copper. Complete loss
FT of receptor activity in the absence of copper."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 300
FT /note="H->K: Decreased receptor activity in response to
FT MTMT binding, even in the presence of copper."
FT /evidence="ECO:0000269|PubMed:22328155"
FT MUTAGEN 307
FT /note="C->V: Decreased receptor activity in response to
FT MTMT binding, even in the presence of copper."
FT /evidence="ECO:0000269|PubMed:22328155"
FT CONFLICT 228
FT /note="Q -> K (in Ref. 1; BAA86125 and 2; AAL60958)"
FT /evidence="ECO:0000305"
FT CONFLICT 248
FT /note="A -> T (in Ref. 1; BAA86125 and 2; AAL60958)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 308 AA; 34986 MW; 7F7508A1BCAA20D0 CRC64;
MGALNQTRVT EFIFLGLTDN WVLEILFFVP FTVTYMLTLL GNFLIVVTIV FTPRLHNPMY
FFLSNLSFID ICHSSVTVPK MLEGLLLERK TISFDNCIAQ LFFLHLFACS EIFLLTIMAY
DRYVAICIPL HYSNVMNMKV CVQLVFALWL GGTIHSLVQT FLTIRLPYCG PNIIDSYFCD
VPPVIKLACT DTYLTGILIV SNSGTISLVC FLALVTSYTV ILFSLRKQSA EGRRKALSTC
SAHFMVVALF FGPCIFLYTR PDSSFSIDKV VSVFYTVVTP LLNPLIYTLR NEEVKTAMKH
LRQRRICS
