O1537_MOUSE
ID O1537_MOUSE Reviewed; 314 AA.
AC P34983; Q7TRB4; Q9EQA1;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Olfactory receptor 1537;
DE AltName: Full=Odorant receptor K4;
DE AltName: Full=Olfactory receptor 144;
DE AltName: Full=Olfactory receptor 7B;
GN Name=Olfr1537; Synonyms=Olfr144, Olfr7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RX PubMed=11130974; DOI=10.1007/s003350010217;
RA Xie S.Y., Feinstein P., Mombaerts P.;
RT "Characterization of a cluster comprising 100 odorant receptor genes in
RT mouse.";
RL Mamm. Genome 11:1070-1078(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-314.
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT of over 400 genes, extensive alternate splicing and unequal expression
RT levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 64-285.
RC STRAIN=C57BL/6J; TISSUE=Liver;
RX PubMed=7683976; DOI=10.1016/0092-8674(93)90145-g;
RA Ressler K.J., Sullivan S.L., Buck L.B.;
RT "A zonal organization of odorant receptor gene expression in the olfactory
RT epithelium.";
RL Cell 73:597-609(1993).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF282288; AAG39873.1; -; Genomic_DNA.
DR EMBL; AY318134; AAP71412.1; -; Genomic_DNA.
DR EMBL; L14569; AAA39853.1; -; Genomic_DNA.
DR CCDS; CCDS23041.1; -.
DR PIR; C40745; C40745.
DR RefSeq; NP_997548.1; NM_207665.1.
DR AlphaFoldDB; P34983; -.
DR SMR; P34983; -.
DR STRING; 10090.ENSMUSP00000072979; -.
DR PaxDb; P34983; -.
DR PRIDE; P34983; -.
DR DNASU; 257959; -.
DR Ensembl; ENSMUST00000073248; ENSMUSP00000072979; ENSMUSG00000096109.
DR GeneID; 257959; -.
DR KEGG; mmu:257959; -.
DR UCSC; uc009oxt.1; mouse.
DR CTD; 257959; -.
DR MGI; MGI:3031371; Olfr1537.
DR VEuPathDB; HostDB:ENSMUSG00000096109; -.
DR eggNOG; ENOG502SJS1; Eukaryota.
DR GeneTree; ENSGT01040000240383; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; P34983; -.
DR OMA; STYINQA; -.
DR OrthoDB; 1075792at2759; -.
DR PhylomeDB; P34983; -.
DR TreeFam; TF336827; -.
DR BioGRID-ORCS; 257959; 2 hits in 35 CRISPR screens.
DR PRO; PR:P34983; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; P34983; protein.
DR ExpressionAtlas; P34983; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Membrane; Olfaction; Receptor;
KW Reference proteome; Sensory transduction; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 1537"
FT /id="PRO_0000150821"
FT TOPO_DOM 1..31
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..184
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..210
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 232..247
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 269..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 114
FT /note="E -> G (in Ref. 3; AAA39853)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 314 AA; 35267 MW; BEDDA3C57D016739 CRC64;
MEDMAAGNHC TVTEFFLAGL SEKPELQLPL FLLFTGIYLI TMAGNLGMIT LIGLSSHLHT
PMYYFLSSLS FIDFCQSTVV IPKMLVSFLT EMNIISYSEC MAQLYFFLTF GIAECYTLAA
MAYDRYVAIC NPLLYNVTMS YQIYSSLISG VYIFAVICSS FNTGFMLRTQ FCNLDVINHY
FCDLLPLLNL ASSNTYINEI LILFFATLNS FVPVLTIITS YIFIIVTILS IHSREGKFKA
FSTCSTHISA VAIFYGSGAF TYLQPSSLNS MGQAKVSSVF YTTVVPMLNP LIYSLRNKDV
SIALKKILER KKFM
