O161_CONCE
ID O161_CONCE Reviewed; 80 AA.
AC Q5K0C4;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 46.
DE RecName: Full=Omega-conotoxin-like 1;
DE Flags: Precursor;
OS Conus capitaneus (Captain cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Rhizoconus.
OX NCBI_TaxID=89439;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=15652641; DOI=10.1016/j.peptides.2004.10.027;
RA Kauferstein S., Melaun C., Mebs D.;
RT "Direct cDNA cloning of novel conopeptide precursors of the O-
RT superfamily.";
RL Peptides 26:361-367(2005).
CC -!- FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and
CC block voltage-gated calcium channels (Cav). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC -!- PTM: Peptide predicted to begin at Arg-51, but it seems more probable
CC that it begins at Cys-52, since this position corresponds to a dibasic
CC residue cleavage. {ECO:0000269|PubMed:15652641}.
CC -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR EMBL; AJ851184; CAH64857.1; -; mRNA.
DR AlphaFoldDB; Q5K0C4; -.
DR SMR; Q5K0C4; -.
DR ConoServer; 1073; Conotoxin-1 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004214; Conotoxin.
DR Pfam; PF02950; Conotoxin; 1.
PE 2: Evidence at transcript level;
KW Calcium channel impairing toxin; Cleavage on pair of basic residues;
KW Disulfide bond; Ion channel impairing toxin; Knottin; Neurotoxin;
KW Presynaptic neurotoxin; Secreted; Signal; Toxin;
KW Voltage-gated calcium channel impairing toxin.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..49
FT /evidence="ECO:0000250"
FT /id="PRO_0000034904"
FT PEPTIDE 52..80
FT /note="Omega-conotoxin-like 1"
FT /id="PRO_0000034905"
FT DISULFID 52..66
FT /evidence="ECO:0000250"
FT DISULFID 59..70
FT /evidence="ECO:0000250"
FT DISULFID 65..79
FT /evidence="ECO:0000250"
SQ SEQUENCE 80 AA; 8936 MW; 42D27A4867456BD2 CRC64;
MKLTCVLIVV VLFLTACQLI TTDDSTGKQR YQAWKLRSKM QNSVLSRLSK RCDEEGTGCS
SDSECCSGRC TPEGLFEFCE