ID   ARP_EUGGR               Reviewed;         695 AA.
AC   Q04732;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Calcium-binding acidic-repeat protein;
DE            Short=ARP;
DE   Flags: Precursor;
OS   Euglena gracilis.
OC   Eukaryota; Discoba; Euglenozoa; Euglenida; Spirocuta; Euglenophyceae;
OC   Euglenales; Euglenaceae; Euglena.
OX   NCBI_TaxID=3039;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1282888; DOI=10.1111/j.1432-1033.1992.tb17473.x;
RA   Gumpel N.J., Smith A.G.;
RT   "A novel calcium-binding protein from Euglena gracilis. Characterisation of
RT   a cDNA encoding a 74-kDa acidic-repeat protein targeted across the
RT   endoplasmic reticulum.";
RL   Eur. J. Biochem. 210:721-727(1992).
CC   -!- FUNCTION: May function as a calcium-binding protein.
CC   -!- SUBCELLULAR LOCATION: Secreted. Endoplasmic reticulum.
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DR   EMBL; X68475; CAA48495.1; -; mRNA.
DR   PIR; S27390; S27390.
DR   AlphaFoldDB; Q04732; -.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   Gene3D; 4.10.1080.10; -; 3.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR028974; TSP_type-3_rpt.
DR   PROSITE; PS00018; EF_HAND_1; 2.
PE   2: Evidence at transcript level;
KW   Calcium; Endoplasmic reticulum; Repeat; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /note="Or 23"
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..695
FT                   /note="Calcium-binding acidic-repeat protein"
FT                   /id="PRO_0000020757"
FT   REPEAT          24..38
FT                   /note="TSP type-3 1"
FT   REPEAT          47..56
FT                   /note="TSP type-3 2"
FT   REPEAT          70..82
FT                   /note="TSP type-3 3"
FT   REPEAT          184..196
FT                   /note="TSP type-3 4"
FT   REPEAT          202..214
FT                   /note="TSP type-3 5"
FT   REPEAT          248..260
FT                   /note="TSP type-3 6"
FT   REPEAT          294..308
FT                   /note="TSP type-3 7"
FT   REPEAT          317..329
FT                   /note="TSP type-3 8"
FT   REPEAT          340..352
FT                   /note="TSP type-3 9"
FT   REPEAT          363..375
FT                   /note="TSP type-3 10"
FT   REPEAT          379..393
FT                   /note="TSP type-3 11"
FT   REPEAT          402..414
FT                   /note="TSP type-3 12"
FT   REPEAT          425..437
FT                   /note="TSP type-3 13"
FT   REPEAT          470..482
FT                   /note="TSP type-3 14"
FT   REPEAT          493..505
FT                   /note="TSP type-3 15"
FT   REPEAT          516..528
FT                   /note="TSP type-3 16"
FT   REPEAT          539..551
FT                   /note="TSP type-3 17"
FT   REPEAT          555..569
FT                   /note="TSP type-3 18"
FT   REPEAT          600..609
FT                   /note="TSP type-3 19"
FT   REPEAT          623..635
FT                   /note="TSP type-3 20"
FT   REPEAT          646..658
FT                   /note="TSP type-3 21"
FT   REGION          45..695
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..74
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..223
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        232..249
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..294
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        309..325
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        326..363
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        444..461
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        479..493
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        526..576
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        585..607
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        665..680
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   695 AA;  73543 MW;  A670F6744CB4A9B8 CRC64;
     MSHLWCWLFL VLCLACLVLS IEAKDSDGDG LLDVDEINVY FTDPYNADSD QDGLTDGLEV
     NRHQTHPQDK DTDDDSIGDG VEVNNLGTNP KDPDSDDDGL TDGAEVNLYR TDPLDADSTT
     TGCPMGGGAE VRHRPQNGDT DDDGLTDGAE VNVHRTNPQD GDSDDDGLSD GAEVNTYHSN
     PKDGDSDDDG VSDGAEVNPK LKDSDGDGLT DEEEIKLYRT DPFCADSDFD GLLDGEEVKV
     HKTNPLDGDS DDDGLGDGAE VTHFNTNPLD ADSDNDGLDD GEEINVHGTD PEDPDSDNDG
     LNDGDEVNVY NTDPEEDDSD EDGVCDGAEV NVHHTNPKDE DSDNDGIPDG AEINTHKTDP
     NDEDSDDDGI ADGAEVTLTD SDGDGLPDED EVALYNTNPA NADSDYDGLT DGAEVKRYQS
     NPLDKDTDDD GLGDGVEVTV GTDPHDATVT TTGSRTAVEI NVHGSDPNDE DTDDDGLTDG
     AEVNLHRTDP EDADTDDDGL TDGAEVNTYR TNPKLADSDG DGLSDGAEVN THKSDPNDGD
     SDDDGVPDAA EAKVKDSDGD GLSDTDEVRF RTNPKLADTD FDGLTDGAEI LKHKTDPRNR
     DTDGDGVADG LEVNTYGSDP KDADTDDDGL TDGAEINVHD TNPTDADSDD DGLSDGAEVM
     TYHTNAKDGD SDDDGKADGA EVSASTDPWR SDHSV