ID   O161_CONQU              Reviewed;          94 AA.
AC   P0DJC6;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=Conotoxin Qc6.1;
DE   Flags: Precursor;
OS   Conus quercinus (Oak cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lividoconus.
OX   NCBI_TaxID=101313;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Hillyard D.R., Mcintosh M.J., Jones R.M., Cartier E.G., Watkins M.,
RA   Olivera B.M., Layer R.T.;
RT   "O-Superfamily conotoxin peptides.";
RL   Patent number JP2003533178, 05-NOV-2002.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   EMBL; DJ379477; -; NOT_ANNOTATED_CDS; Unassigned_DNA.
DR   AlphaFoldDB; P0DJC6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Knottin; Neurotoxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..62
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000415313"
FT   PEPTIDE         65..94
FT                   /note="Conotoxin Qc6.1"
FT                   /id="PRO_0000415314"
FT   DISULFID        66..84
FT                   /evidence="ECO:0000250"
FT   DISULFID        73..88
FT                   /evidence="ECO:0000250"
FT   DISULFID        83..92
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   94 AA;  10302 MW;  EC0CDF050F50FCAA CRC64;
     MKLTCMMIVA LLFLTAWTFV TAVDSKNELE NRGGWGQAGG WGKLFPMARD EMKNSEVSKL
     DNKRKCAAAG EACVIPIIGN VFCCKGYCLF VCIS