ID   O162_CONLI              Reviewed;          77 AA.
AC   Q3YEG6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Conotoxin LiC42;
DE   Flags: Precursor;
OS   Conus lividus (Livid cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lividoconus.
OX   NCBI_TaxID=89426;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=17177885; DOI=10.1111/j.1747-0285.2006.00443.x;
RA   Zhangsun D., Luo S., Wu Y., Zhu X., Hu Y., Xie L.;
RT   "Novel O-superfamily conotoxins identified by cDNA cloning from three
RT   vermivorous Conus species.";
RL   Chem. Biol. Drug Des. 68:256-265(2006).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   EMBL; DQ141147; AAZ83783.1; -; mRNA.
DR   AlphaFoldDB; Q3YEG6; -.
DR   SMR; Q3YEG6; -.
DR   ConoServer; 1135; LiC42 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Knottin; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..47
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000315488"
FT   PEPTIDE         48..77
FT                   /note="Conotoxin LiC42"
FT                   /id="PRO_0000315489"
FT   DISULFID        49..62
FT                   /evidence="ECO:0000250"
FT   DISULFID        56..67
FT                   /evidence="ECO:0000250"
FT   DISULFID        61..76
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   77 AA;  8139 MW;  C6B5C44EBC03E21D CRC64;
     MKLTCVLIIA VLFLTASQLI TADYSRDKQE YGAERLRDAM GKFKGSRSCG HSGAGCYTRP
     CCPGLHCSGG HAGGLCV