O162_CONVR
ID O162_CONVR Reviewed; 81 AA.
AC Q3YED8;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 1.
DT 25-MAY-2022, entry version 31.
DE RecName: Full=Conotoxin ViKr92;
DE Flags: Precursor;
OS Conus virgo (Virgin cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Virgiconus.
OX NCBI_TaxID=89427;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=17011667; DOI=10.1016/j.peptides.2006.08.013;
RA Luo S., Zhangsun D., Lin Q., Xie L., Wu Y., Zhu X.;
RT "Sequence diversity of O-superfamily conopeptides from Conus marmoreus
RT native to Hainan.";
RL Peptides 27:3058-3068(2006).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR EMBL; DQ141175; AAZ83774.1; -; mRNA.
DR AlphaFoldDB; Q3YED8; -.
DR SMR; Q3YED8; -.
DR ConoServer; 1129; ViKr92 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004214; Conotoxin.
DR Pfam; PF02950; Conotoxin; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Knottin; Neurotoxin; Secreted; Signal; Toxin.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..51
FT /evidence="ECO:0000305"
FT /id="PRO_0000315518"
FT PEPTIDE 52..81
FT /note="Conotoxin ViKr92"
FT /id="PRO_0000315519"
FT DISULFID 53..70
FT /evidence="ECO:0000250"
FT DISULFID 60..74
FT /evidence="ECO:0000250"
FT DISULFID 69..78
FT /evidence="ECO:0000250"
SQ SEQUENCE 81 AA; 9148 MW; 3A732016EA41FCEC CRC64;
MKLTWMMIVA VLFLTAWTFV TADDTRYKLE NPFLKARNEL QKLEASQLNE RGCLDPGYFC
GTPFLGAYCC GGICLIVCIE T