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ARR12_ARATH
ID   ARR12_ARATH             Reviewed;         596 AA.
AC   P62598; F4IRL1;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   22-FEB-2012, sequence version 2.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=Two-component response regulator ARR12;
GN   Name=ARR12; OrderedLocusNames=At2g25180; ORFNames=F13D4.140;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 309-442.
RX   PubMed=11115876; DOI=10.1104/pp.124.4.1582;
RA   White J.A., Todd J., Newman T., Focks N., Girke T., de Ilarduya O.M.,
RA   Jaworski J.G., Ohlrogge J.B., Benning C.;
RT   "A new set of Arabidopsis expressed sequence tags from developing seeds.
RT   The metabolic pathway from carbohydrates to seed oil.";
RL   Plant Physiol. 124:1582-1594(2000).
RN   [4]
RP   TISSUE SPECIFICITY.
RX   PubMed=15173562; DOI=10.1104/pp.103.038109;
RA   Mason M.G., Li J., Mathews D.E., Kieber J.J., Schaller G.E.;
RT   "Type-B response regulators display overlapping expression patterns in
RT   Arabidopsis.";
RL   Plant Physiol. 135:927-937(2004).
RN   [5]
RP   FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=17363254; DOI=10.1016/j.cub.2007.02.047;
RA   Dello Ioio R., Linhares F.S., Scacchi E., Casamitjana-Martinez E.,
RA   Heidstra R., Costantino P., Sabatini S.;
RT   "Cytokinins determine Arabidopsis root-meristem size by controlling cell
RT   differentiation.";
RL   Curr. Biol. 17:678-682(2007).
RN   [6]
RP   FUNCTION.
RX   PubMed=20605455; DOI=10.1016/j.cub.2010.05.035;
RA   Moubayidin L., Perilli S., Dello Ioio R., Di Mambro R., Costantino P.,
RA   Sabatini S.;
RT   "The rate of cell differentiation controls the Arabidopsis root meristem
RT   growth phase.";
RL   Curr. Biol. 20:1138-1143(2010).
CC   -!- FUNCTION: Transcriptional activator that binds specifically to the DNA
CC       sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in
CC       His-to-Asp phosphorelay signal transduction system. Phosphorylation of
CC       the Asp residue in the receiver domain activates the ability of the
CC       protein to promote the transcription of target genes. Could directly
CC       activate some type-A response regulators in response to cytokinins.
CC       Involved in the root-meristem size determination through the regulation
CC       of cell differentiation (PubMed:17363254). Involved in activating SHY2
CC       during meristem growth and controls PIN expression via activation of
CC       SHY2 (PubMed:20605455). {ECO:0000250|UniProtKB:Q940D0,
CC       ECO:0000269|PubMed:17363254, ECO:0000269|PubMed:20605455}.
CC   -!- SUBUNIT: Binds the target DNA as a monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Detected in the whole plant. Predominantly
CC       expressed in leaves. Expressed at the root transition zone
CC       (PubMed:17363254). {ECO:0000269|PubMed:15173562,
CC       ECO:0000269|PubMed:17363254}.
CC   -!- DEVELOPMENTAL STAGE: Detected immediately after seed germination.
CC       {ECO:0000269|PubMed:17363254}.
CC   -!- PTM: Two-component system major event consists of a His-to-Asp
CC       phosphorelay between a sensor histidine kinase (HK) and a response
CC       regulator (RR). In plants, the His-to-Asp phosphorelay involves an
CC       additional intermediate named Histidine-containing phosphotransfer
CC       protein (HPt). This multistep phosphorelay consists of a His-Asp-His-
CC       Asp sequential transfer of a phosphate group between first an His and
CC       an Asp of the HK protein, followed by the transfer to a conserved His
CC       of the HPt protein and finally the transfer to an Asp in the receiver
CC       domain of the RR protein.
CC   -!- SIMILARITY: Belongs to the ARR family. Type-B subfamily. {ECO:0000305}.
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DR   EMBL; CP002685; AEC07667.1; -; Genomic_DNA.
DR   EMBL; BE522295; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; NP_180090.6; NM_128075.7.
DR   AlphaFoldDB; P62598; -.
DR   SMR; P62598; -.
DR   BioGRID; 2408; 8.
DR   IntAct; P62598; 2.
DR   STRING; 3702.AT2G25180.1; -.
DR   PaxDb; P62598; -.
DR   PRIDE; P62598; -.
DR   ProteomicsDB; 246895; -.
DR   EnsemblPlants; AT2G25180.1; AT2G25180.1; AT2G25180.
DR   GeneID; 817056; -.
DR   Gramene; AT2G25180.1; AT2G25180.1; AT2G25180.
DR   KEGG; ath:AT2G25180; -.
DR   Araport; AT2G25180; -.
DR   TAIR; locus:2040194; AT2G25180.
DR   eggNOG; KOG1601; Eukaryota.
DR   HOGENOM; CLU_024359_0_0_1; -.
DR   InParanoid; P62598; -.
DR   OMA; MPLEFDQ; -.
DR   OrthoDB; 332559at2759; -.
DR   PRO; PR:P62598; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; P62598; baseline and differential.
DR   Genevisible; P62598; AT.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; ISS:TAIR.
DR   GO; GO:1990110; P:callus formation; IGI:TAIR.
DR   GO; GO:0071368; P:cellular response to cytokinin stimulus; IMP:TAIR.
DR   GO; GO:0009736; P:cytokinin-activated signaling pathway; IGI:TAIR.
DR   GO; GO:0010492; P:maintenance of shoot apical meristem identity; IGI:TAIR.
DR   GO; GO:0080022; P:primary root development; IGI:TAIR.
DR   GO; GO:0031537; P:regulation of anthocyanin metabolic process; IGI:TAIR.
DR   GO; GO:0010380; P:regulation of chlorophyll biosynthetic process; IGI:TAIR.
DR   GO; GO:0080036; P:regulation of cytokinin-activated signaling pathway; IMP:CACAO.
DR   GO; GO:0010082; P:regulation of root meristem growth; IMP:CACAO.
DR   GO; GO:0080113; P:regulation of seed growth; IMP:TAIR.
DR   GO; GO:0009735; P:response to cytokinin; IGI:TAIR.
DR   GO; GO:0009414; P:response to water deprivation; IGI:TAIR.
DR   GO; GO:0048364; P:root development; IMP:TAIR.
DR   GO; GO:0048367; P:shoot system development; IGI:TAIR.
DR   InterPro; IPR045279; ARR-like.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR006447; Myb_dom_plants.
DR   InterPro; IPR017053; Response_reg_B-typ_pln.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   PANTHER; PTHR43874; PTHR43874; 1.
DR   Pfam; PF00249; Myb_DNA-binding; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   PIRSF; PIRSF036392; RR_ARR_type-B; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   TIGRFAMs; TIGR01557; myb_SHAQKYF; 1.
DR   PROSITE; PS51294; HTH_MYB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cytokinin signaling pathway; DNA-binding; Nucleus;
KW   Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..596
FT                   /note="Two-component response regulator ARR12"
FT                   /id="PRO_0000132297"
FT   DOMAIN          18..133
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        197..247
FT                   /note="Myb-like GARP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   REGION          138..192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          437..467
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           194..197
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        147..165
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        437..461
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         69
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   CONFLICT        414
FT                   /note="G -> S (in Ref. 3; BE522295)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        426
FT                   /note="H -> T (in Ref. 3; BE522295)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   596 AA;  65626 MW;  C9E0D3F5EEE1B149 CRC64;
     MTVEQNLEAL DQFPVGMRVL AVDDDQTCLK ILESLLRHCQ YHVTTTNQAQ KALELLRENK
     NKFDLVISDV DMPDMDGFKL LELVGLEMDL PVIMLSAHSD PKYVMKGVTH GACDYLLKPV
     RIEELKNIWQ HVVRSRFDKN RGSNNNGDKR DGSGNEGVGN SDQNNGKGNR KRKDQYNEDE
     DEDRDDNDDS CAQKKQRVVW TVELHKKFVA AVNQLGYEKA MPKKILDLMN VEKLTRENVA
     SHLQKFRLYL KRISGVANQQ AIMANSELHF MQMNGLDGFH HRPIPVGSGQ YHGGAPAMRS
     FPPNGILGRL NTPSGIGVRS LSSPPAGMFL QNQTDIGKFH HVSSLPLNHS DGGNILQGLP
     MPLEFDQLQT NNNKSRNMNS NKSIAGTSMA FPSFSTQQNS LISAPNNNVV VLEGHPQATP
     PGFPGHQINK RLEHWSNAVS SSTHPPPPAH NSNSINHQFD VSPLPHSRPD PLEWNNVSSS
     YSIPFCDSAN TLSSPALDTT NPRAFCRNTD FDSNTNVQPG VFYGPSTDAM ALLSSSNPKE
     GFVVGQQKLQ SGGFMVADAG SLDDIVNSTM KQEQSQGDLS GGDLGYGGFS SLRTCI
 
 
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