ID   O163B_CONCL             Reviewed;          28 AA.
AC   P0DJB2;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Conotoxin Cal6.43b {ECO:0000305};
DE   AltName: Full=Conotoxin Cal6.5a {ECO:0000303|PubMed:21172372};
OS   Californiconus californicus (California cone) (Conus californicus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX   NCBI_TaxID=1736779;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=21172372; DOI=10.1016/j.toxicon.2010.12.008;
RA   Elliger C.A., Richmond T.A., Lebaric Z.N., Pierce N.T., Sweedler J.V.,
RA   Gilly W.F.;
RT   "Diversity of conotoxin types from Conus californicus reflects a diversity
RT   of prey types and a novel evolutionary history.";
RL   Toxicon 57:311-322(2011).
CC   -!- FUNCTION: Probable neurotoxin with unknown target. Possibly targets ion
CC       channels. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21172372}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:21172372}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- CAUTION: This peptide does not correspond to any sequence of the cDNA
CC       library. {ECO:0000305}.
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DR   AlphaFoldDB; P0DJB2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Knottin; Neurotoxin; Secreted; Toxin.
FT   PEPTIDE         1..28
FT                   /note="Conotoxin Cal6.43b"
FT                   /evidence="ECO:0000269|PubMed:21172372"
FT                   /id="PRO_0000414976"
FT   DISULFID        3..13
FT                   /evidence="ECO:0000250"
FT   DISULFID        7..19
FT                   /evidence="ECO:0000250"
FT   DISULFID        12..25
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   28 AA;  3000 MW;  BCAE9CFBF3AC0568 CRC64;
     DDCTTYCYGV HCCPPAFKCA ASPSCKQT