ID   O163_CONLT              Reviewed;          72 AA.
AC   Q2I2R2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Conotoxin Lt6.3;
DE   AltName: Full=Lt6c;
DE   Flags: Precursor;
OS   Conus litteratus (Lettered cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Elisaconus.
OX   NCBI_TaxID=89445;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=16908117; DOI=10.1016/j.ygeno.2006.06.014;
RA   Pi C., Liu J., Peng C., Liu Y., Jiang X., Zhao Y., Tang S., Wang L.,
RA   Dong M., Chen S., Xu A.;
RT   "Diversity and evolution of conotoxins based on gene expression profiling
RT   of Conus litteratus.";
RL   Genomics 88:809-819(2006).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   EMBL; DQ345370; ABC74978.1; -; mRNA.
DR   AlphaFoldDB; Q2I2R2; -.
DR   SMR; Q2I2R2; -.
DR   ConoServer; 1156; LtVIC precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Knottin; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..46
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000315496"
FT   PEPTIDE         47..72
FT                   /note="Conotoxin Lt6.3"
FT                   /id="PRO_0000315497"
FT   DISULFID        47..61
FT                   /evidence="ECO:0000250"
FT   DISULFID        54..64
FT                   /evidence="ECO:0000250"
FT   DISULFID        60..71
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   72 AA;  7748 MW;  08F150258064A1C1 CRC64;
     MKLTSVVIVA VLFLAACQLT TSDGSRGTWK DRAVRSITKV SMLRWPCKVA GSPCGLVSEC
     CGTCNVLRNR CV