ARR13_ARATH
ID ARR13_ARATH Reviewed; 572 AA.
AC Q9ZVD3; F4IVP4;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 2.
DT 25-MAY-2022, entry version 151.
DE RecName: Full=Putative two-component response regulator ARR13;
GN Name=ARR13; OrderedLocusNames=At2g27070; ORFNames=T20P8.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Putative transcriptional activator that binds specifically to
CC the DNA sequence 5'-[AG]GATT-3'. Functions as response regulator
CC involved in His-to-Asp phosphorelay signal transduction system.
CC Phosphorylation of the Asp residue in the receiver domain activates the
CC ability of the protein to promote the transcription of target genes.
CC Could directly activate some type-A response regulators in response to
CC cytokinins (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds the target DNA as a monomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- PTM: Two-component system major event consists of a His-to-Asp
CC phosphorelay between a sensor histidine kinase (HK) and a response
CC regulator (RR). In plants, the His-to-Asp phosphorelay involves an
CC additional intermediate named Histidine-containing phosphotransfer
CC protein (HPt). This multistep phosphorelay consists of a His-Asp-His-
CC Asp sequential transfer of a phosphate group between first an His and
CC an Asp of the HK protein, followed by the transfer to a conserved His
CC of the HPt protein and finally the transfer to an Asp in the receiver
CC domain of the RR protein.
CC -!- SIMILARITY: Belongs to the ARR family. Type-B subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC77865.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC005623; AAC77865.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC07932.2; -; Genomic_DNA.
DR PIR; D84668; D84668.
DR RefSeq; NP_001318296.1; NM_001336100.1.
DR AlphaFoldDB; Q9ZVD3; -.
DR SMR; Q9ZVD3; -.
DR BioGRID; 2601; 1.
DR STRING; 3702.AT2G27070.1; -.
DR PaxDb; Q9ZVD3; -.
DR PRIDE; Q9ZVD3; -.
DR ProteomicsDB; 246896; -.
DR EnsemblPlants; AT2G27070.1; AT2G27070.1; AT2G27070.
DR GeneID; 817249; -.
DR Gramene; AT2G27070.1; AT2G27070.1; AT2G27070.
DR KEGG; ath:AT2G27070; -.
DR Araport; AT2G27070; -.
DR eggNOG; KOG1601; Eukaryota.
DR HOGENOM; CLU_387641_0_0_1; -.
DR InParanoid; Q9ZVD3; -.
DR OMA; FIQKPIK; -.
DR OrthoDB; 617429at2759; -.
DR PhylomeDB; Q9ZVD3; -.
DR PRO; PR:Q9ZVD3; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZVD3; baseline and differential.
DR Genevisible; Q9ZVD3; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0009736; P:cytokinin-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR InterPro; IPR045279; ARR-like.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006447; Myb_dom_plants.
DR InterPro; IPR017053; Response_reg_B-typ_pln.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43874; PTHR43874; 3.
DR Pfam; PF00072; Response_reg; 1.
DR PIRSF; PIRSF036392; RR_ARR_type-B; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR TIGRFAMs; TIGR01557; myb_SHAQKYF; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Activator; Cytokinin signaling pathway; DNA-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Two-component regulatory system.
FT CHAIN 1..572
FT /note="Putative two-component response regulator ARR13"
FT /id="PRO_0000132298"
FT DOMAIN 17..134
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 227..277
FT /note="Myb-like GARP"
FT REGION 175..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 224..227
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 182..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 71
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 572 AA; 65044 MW; CC0A0F1438AFFFE1 CRC64;
MAFAQSVYNQ SSVLKINVMV VDDNRVFLDI WSRMLEKSKY REITVIAVDY PKKALSTLKN
QRDNIDLIIT DYYMPGMNGL QLKKQITQEF GNLSVLVMSS DPNKEEESLS CGAMGFIPKP
IAPTDLPKIY QFALTYKRNG KSTLSTEQNQ KDANVSVPQQ IMLVPEQAYV LKTKKKNCSS
KSDTRTVNST NVSHVSTNGS RKNRKRKPKG GPSDDGESLS QPPKKKKIWW TNPLQDLFLQ
AIQHIGYDKV VPKKILAIMN VPYLTRENVA SHLQKYRLFV KRVVHQGRFS MLSDRGKDSM
FRQTHIKEPY VNYYTPSTSW YETSLNNRSF YSESVHGHSR LLSEAREPVR YNQMSYNYMN
RNISFENQPS QNEETRTVFE PPVMANKISQ TSQVLGFGQL GPSAISGHNF NTNMMSSYGS
LTPNQPGTSH FSYGMQSVLN NENATYNPQP PANATTQPNL DELPQLENLN LYNDLGNTSE
LPYNISNFQS DDNKKQGEED GDWTFVNINQ DQSNGESSNT IATPETNTPN FNINPNQNQG
QAVPEFTDWS FLDQQELVDD DFMNSLFNND MN
