ID   O163_CONST              Reviewed;          72 AA.
AC   Q5K0D7; Q9N646;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Conotoxin 3;
DE   AltName: Full=S6.9;
DE   Flags: Precursor;
OS   Conus striatus (Striated cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX   NCBI_TaxID=6493;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=15652641; DOI=10.1016/j.peptides.2004.10.027;
RA   Kauferstein S., Melaun C., Mebs D.;
RT   "Direct cDNA cloning of novel conopeptide precursors of the O-
RT   superfamily.";
RL   Peptides 26:361-367(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=16183187; DOI=10.1016/j.biochi.2005.08.001;
RA   Pi C., Liu Y., Peng C., Jiang X., Liu J., Xu B., Yu X., Yu Y., Jiang X.,
RA   Wang L., Dong M., Chen S., Xu A.-L.;
RT   "Analysis of expressed sequence tags from the venom ducts of Conus
RT   striatus: focusing on the expression profile of conotoxins.";
RL   Biochimie 88:131-140(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-72.
RA   Duda T.F., Palumbi S.R.;
RT   "Molecular evolution of four-loop conotoxin precursors from fish-eating
RT   Conus.";
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   EMBL; AJ851171; CAH64844.1; -; mRNA.
DR   EMBL; AF174252; AAF89916.1; -; Genomic_DNA.
DR   EMBL; AF174249; AAF89913.1; -; Genomic_DNA.
DR   EMBL; AF174250; AAF89914.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5K0D7; -.
DR   SMR; Q5K0D7; -.
DR   ConoServer; 1060; Conotoxin-3 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Knottin; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..46
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000034995"
FT   PEPTIDE         47..72
FT                   /note="Conotoxin 3"
FT                   /id="PRO_0000034996"
FT   DISULFID        47..61
FT                   /evidence="ECO:0000250"
FT   DISULFID        54..64
FT                   /evidence="ECO:0000250"
FT   DISULFID        60..71
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   72 AA;  7856 MW;  6A6EED2C13994EF7 CRC64;
     MKLTCVVIVA VLLLTACQLI TADDSRGTQE HRALRSDTKL SMLTLRCESY GKPCGIYNDC
     CNACDPAKKT CT