ID   O1642_CONMI             Reviewed;          82 AA.
AC   Q3YEG3;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Conotoxin MiK42;
DE   Flags: Precursor;
OS   Conus miles (Soldier cone) (Mile cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Rhizoconus.
OX   NCBI_TaxID=69564;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=17106905; DOI=10.1002/psc.802;
RA   Luo S., Zhangsun D., Feng J., Wu Y., Zhu X., Hu Y.;
RT   "Diversity of the O-superfamily conotoxins from Conus miles.";
RL   J. Pept. Sci. 13:44-53(2007).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   EMBL; DQ141150; AAZ83751.1; -; mRNA.
DR   AlphaFoldDB; Q3YEG3; -.
DR   ConoServer; 1111; MiK42 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Knottin; Neurotoxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..49
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000273431"
FT   PEPTIDE         52..82
FT                   /note="Conotoxin MiK42"
FT                   /id="PRO_0000273432"
FT   DISULFID        52..67
FT                   /evidence="ECO:0000250"
FT   DISULFID        59..70
FT                   /evidence="ECO:0000250"
FT   DISULFID        66..80
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   82 AA;  9482 MW;  EA4948DEA0537014 CRC64;
     MKLTCALIVA MLLLTACQLI TTDDFRGRQQ YRTARSRTKM QNYKIFRLTK RCDAPNAPCE
     KFDNDCCDAC MLREKQQPIC AV