ID   O164_CONLE              Reviewed;          79 AA.
AC   P0C905;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Conotoxin Leo-O4 {ECO:0000303|PubMed:18221274};
DE   Flags: Precursor;
OS   Conus leopardus (Leopard cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lithoconus.
OX   NCBI_TaxID=101306;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=18221274; DOI=10.1111/j.1365-294x.2007.03627.x;
RA   Remigio E.A., Duda T.F. Jr.;
RT   "Evolution of ecological specialization and venom of a predatory marine
RT   gastropod.";
RL   Mol. Ecol. 17:1156-1162(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:18221274}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:18221274}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   EMBL; EF467319; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P0C905; -.
DR   ConoServer; 3717; Lp6.3 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Knottin; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..51
FT                   /evidence="ECO:0000305|PubMed:18221274"
FT                   /id="PRO_0000368010"
FT   PEPTIDE         52..79
FT                   /note="Conotoxin Leo-O4"
FT                   /evidence="ECO:0000305|PubMed:18221274"
FT                   /id="PRO_0000368011"
FT   DISULFID        53..70
FT                   /evidence="ECO:0000250|UniProtKB:P18511"
FT   DISULFID        60..74
FT                   /evidence="ECO:0000250|UniProtKB:P18511"
FT   DISULFID        69..78
FT                   /evidence="ECO:0000250|UniProtKB:P18511"
SQ   SEQUENCE   79 AA;  8775 MW;  0132FEB4FAFA2DA5 CRC64;
     MKLTCMMLVA VLFLTAWTFV TANVSRNGLE NLFPEERHEM MNPNAAKLNN RDCVKAGTAC
     GFPKPEPACC SSWCIFVCT