ARR15_ARATH
ID ARR15_ARATH Reviewed; 206 AA.
AC Q7G8V2;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Two-component response regulator ARR15;
GN Name=ARR15; OrderedLocusNames=At1g74890; ORFNames=F25A4.14, F9E10.26;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE, AND INDUCTION.
RC STRAIN=cv. Columbia;
RX PubMed=11115887; DOI=10.1104/pp.124.4.1706;
RA D'Agostino I.B., Deruere J., Kieber J.J.;
RT "Characterization of the response of the Arabidopsis response regulator
RT gene family to cytokinin.";
RL Plant Physiol. 124:1706-1717(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=12354925; DOI=10.1093/pcp/pcf121;
RA Kiba T., Yamada H., Mizuno T.;
RT "Characterization of the ARR15 and ARR16 response regulators with special
RT reference to the cytokinin signaling pathway mediated by the AHK4 histidine
RT kinase in roots of Arabidopsis thaliana.";
RL Plant Cell Physiol. 43:1059-1066(2002).
RN [5]
RP FUNCTION.
RX PubMed=12941880; DOI=10.1093/pcp/pcg108;
RA Kiba T., Yamada H., Sato S., Kato T., Tabata S., Yamashino T., Mizuno T.;
RT "The type-A response regulator, ARR15, acts as a negative regulator in the
RT cytokinin-mediated signal transduction in Arabidopsis thaliana.";
RL Plant Cell Physiol. 44:868-874(2003).
RN [6]
RP FUNCTION.
RX PubMed=14973166; DOI=10.1105/tpc.018978;
RA To J.P.C., Haberer G., Ferreira F.J., Deruere J., Mason M.G.,
RA Schaller G.E., Alonso J.M., Ecker J.R., Kieber J.J.;
RT "Type-A Arabidopsis response regulators are partially redundant negative
RT regulators of cytokinin signaling.";
RL Plant Cell 16:658-671(2004).
CC -!- FUNCTION: Functions as response regulator involved in His-to-Asp
CC phosphorelay signal transduction system. Phosphorylation of the Asp
CC residue in the receiver domain activates the ability of the protein to
CC promote the transcription of target genes. Type-A response regulators
CC seem to act as negative regulators of the cytokinin signaling.
CC {ECO:0000269|PubMed:12354925, ECO:0000269|PubMed:12941880,
CC ECO:0000269|PubMed:14973166}.
CC -!- INTERACTION:
CC Q7G8V2; Q67XQ1: At1g03430; NbExp=2; IntAct=EBI-1100967, EBI-1100725;
CC Q7G8V2; Q9C5A5: At5g08720/T2K12_70; NbExp=3; IntAct=EBI-1100967, EBI-1998000;
CC Q7G8V2; Q9SSW0: AZF3; NbExp=2; IntAct=EBI-1100967, EBI-1807790;
CC Q7G8V2; Q9C9L2: TCP15; NbExp=3; IntAct=EBI-1100967, EBI-4426144;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12354925}.
CC -!- INDUCTION: By cytokinin (BA) in roots. {ECO:0000269|PubMed:11115887,
CC ECO:0000269|PubMed:12354925}.
CC -!- PTM: Two-component system major event consists of a His-to-Asp
CC phosphorelay between a sensor histidine kinase (HK) and a response
CC regulator (RR). In plants, the His-to-Asp phosphorelay involves an
CC additional intermediate named Histidine-containing phosphotransfer
CC protein (HPt). This multistep phosphorelay consists of a His-Asp-His-
CC Asp sequential transfer of a phosphate group between first an His and
CC an Asp of the HK protein, followed by the transfer to a conserved His
CC of the HPt protein and finally the transfer to an Asp in the receiver
CC domain of the RR protein.
CC -!- SIMILARITY: Belongs to the ARR family. Type-A subfamily. {ECO:0000305}.
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DR EMBL; AF305720; AAG40611.1; -; mRNA.
DR EMBL; AC008263; AAD55287.1; -; Genomic_DNA.
DR EMBL; AC013258; AAG51914.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE35644.1; -; Genomic_DNA.
DR RefSeq; NP_177627.1; NM_106147.2.
DR AlphaFoldDB; Q7G8V2; -.
DR SMR; Q7G8V2; -.
DR BioGRID; 29047; 12.
DR IntAct; Q7G8V2; 13.
DR STRING; 3702.AT1G74890.1; -.
DR PaxDb; Q7G8V2; -.
DR PRIDE; Q7G8V2; -.
DR ProteomicsDB; 246929; -.
DR EnsemblPlants; AT1G74890.1; AT1G74890.1; AT1G74890.
DR GeneID; 843828; -.
DR Gramene; AT1G74890.1; AT1G74890.1; AT1G74890.
DR KEGG; ath:AT1G74890; -.
DR Araport; AT1G74890; -.
DR TAIR; locus:2027237; AT1G74890.
DR eggNOG; KOG1601; Eukaryota.
DR HOGENOM; CLU_000445_69_5_1; -.
DR InParanoid; Q7G8V2; -.
DR OMA; DKAKHSY; -.
DR OrthoDB; 1311174at2759; -.
DR PhylomeDB; Q7G8V2; -.
DR PRO; PR:Q7G8V2; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q7G8V2; baseline and differential.
DR Genevisible; Q7G8V2; AT.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0000156; F:phosphorelay response regulator activity; ISS:TAIR.
DR GO; GO:0009736; P:cytokinin-activated signaling pathway; TAS:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR GO; GO:0009735; P:response to cytokinin; IEP:TAIR.
DR InterPro; IPR045279; ARR-like.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43874; PTHR43874; 1.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 1: Evidence at protein level;
KW Cytokinin signaling pathway; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Two-component regulatory system.
FT CHAIN 1..206
FT /note="Two-component response regulator ARR15"
FT /id="PRO_0000081431"
FT DOMAIN 19..146
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT REGION 151..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..206
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 79
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 206 AA; 22401 MW; ADA6D59CA8491EC7 CRC64;
MALRDLSSSL SSSSSPELHV LAVDDSFVDR KVIERLLKIS ACKVTTVESG TRALQYLGLD
GDNGSSGLKD LKVNLIVTDY SMPGLTGYEL LKKIKESSAL REIPVVIMSS ENIQPRIEQC
MIEGAEEFLL KPVKLADVKR LKELIMRGGE AEEGKTKKLS PKRILQNDID SSPSSSSTSS
SSSSHDVSSL DDDTPSSKRI KLESRG
