ARR16_ARATH
ID ARR16_ARATH Reviewed; 164 AA.
AC Q9SHC2;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Two-component response regulator ARR16;
GN Name=ARR16; OrderedLocusNames=At2g40670; ORFNames=T7D17.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RC STRAIN=cv. Columbia;
RX PubMed=11115887; DOI=10.1104/pp.124.4.1706;
RA D'Agostino I.B., Deruere J., Kieber J.J.;
RT "Characterization of the response of the Arabidopsis response regulator
RT gene family to cytokinin.";
RL Plant Physiol. 124:1706-1717(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RA Bezhani S., Pfannschmidt T., Oelmueller R.;
RT "Expression of a new Arabidopsis thaliana type A response regulator.";
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP FUNCTION, AND INDUCTION.
RX PubMed=12354925; DOI=10.1093/pcp/pcf121;
RA Kiba T., Yamada H., Mizuno T.;
RT "Characterization of the ARR15 and ARR16 response regulators with special
RT reference to the cytokinin signaling pathway mediated by the AHK4 histidine
RT kinase in roots of Arabidopsis thaliana.";
RL Plant Cell Physiol. 43:1059-1066(2002).
RN [6]
RP FUNCTION.
RX PubMed=14973166; DOI=10.1105/tpc.018978;
RA To J.P.C., Haberer G., Ferreira F.J., Deruere J., Mason M.G.,
RA Schaller G.E., Alonso J.M., Ecker J.R., Kieber J.J.;
RT "Type-A Arabidopsis response regulators are partially redundant negative
RT regulators of cytokinin signaling.";
RL Plant Cell 16:658-671(2004).
CC -!- FUNCTION: Functions as response regulator involved in His-to-Asp
CC phosphorelay signal transduction system. Phosphorylation of the Asp
CC residue in the receiver domain activates the ability of the protein to
CC promote the transcription of target genes. Type-A response regulators
CC seem to act as negative regulators of the cytokinin signaling.
CC {ECO:0000269|PubMed:12354925, ECO:0000269|PubMed:14973166}.
CC -!- INTERACTION:
CC Q9SHC2; Q9ZNV8: AHP2; NbExp=2; IntAct=EBI-1100982, EBI-1100687;
CC Q9SHC2; Q9SAZ5: AHP3; NbExp=2; IntAct=EBI-1100982, EBI-1100711;
CC Q9SHC2; Q67XQ1: At1g03430; NbExp=3; IntAct=EBI-1100982, EBI-1100725;
CC Q9SHC2; Q9C9L2: TCP15; NbExp=3; IntAct=EBI-1100982, EBI-4426144;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9SHC2-1; Sequence=Displayed;
CC -!- INDUCTION: By cytokinin (BA) in roots. {ECO:0000269|PubMed:11115887,
CC ECO:0000269|PubMed:12354925}.
CC -!- PTM: Two-component system major event consists of a His-to-Asp
CC phosphorelay between a sensor histidine kinase (HK) and a response
CC regulator (RR). In plants, the His-to-Asp phosphorelay involves an
CC additional intermediate named Histidine-containing phosphotransfer
CC protein (HPt). This multistep phosphorelay consists of a His-Asp-His-
CC Asp sequential transfer of a phosphate group between first an His and
CC an Asp of the HK protein, followed by the transfer to a conserved His
CC of the HPt protein and finally the transfer to an Asp in the receiver
CC domain of the RR protein.
CC -!- SIMILARITY: Belongs to the ARR family. Type-A subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF305721; AAG40612.1; -; mRNA.
DR EMBL; AJ279079; CAC10396.1; -; mRNA.
DR EMBL; CP002685; AEC09862.1; -; Genomic_DNA.
DR PIR; D84832; D84832.
DR RefSeq; NP_181599.1; NM_129629.3. [Q9SHC2-1]
DR AlphaFoldDB; Q9SHC2; -.
DR SMR; Q9SHC2; -.
DR BioGRID; 4000; 9.
DR IntAct; Q9SHC2; 10.
DR STRING; 3702.AT2G40670.2; -.
DR PaxDb; Q9SHC2; -.
DR PRIDE; Q9SHC2; -.
DR EnsemblPlants; AT2G40670.1; AT2G40670.1; AT2G40670. [Q9SHC2-1]
DR GeneID; 818662; -.
DR Gramene; AT2G40670.1; AT2G40670.1; AT2G40670. [Q9SHC2-1]
DR KEGG; ath:AT2G40670; -.
DR Araport; AT2G40670; -.
DR eggNOG; KOG1601; Eukaryota.
DR HOGENOM; CLU_000445_69_5_1; -.
DR InParanoid; Q9SHC2; -.
DR OMA; GANGFLM; -.
DR PhylomeDB; Q9SHC2; -.
DR PRO; PR:Q9SHC2; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SHC2; baseline and differential.
DR Genevisible; Q9SHC2; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0009736; P:cytokinin-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR InterPro; IPR045279; ARR-like.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43874; PTHR43874; 2.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytokinin signaling pathway; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation;
KW Two-component regulatory system.
FT CHAIN 1..164
FT /note="Two-component response regulator ARR16"
FT /id="PRO_0000081432"
FT DOMAIN 30..160
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT MOD_RES 93
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 164 AA; 18268 MW; FB82BD88D7BEC615 CRC64;
MNSSGGSCSS LMDVVAYDHH LHHGHDEELH VLAVDDNLID RKLVERLLKI SCCKVTTAEN
ALRALEYLGL GDQNQHIDAL TCNVMKVSLI ITDYCMPGMT GFELLKKVKE SSNLREVPVV
IMSSENIPTR INKCLASGAQ MFMQKPLKLA DVEKLKCHLM NCRS
